Tumor grade as significant prognostic factor in pancreatic
cancer: validation of a novel TNMG staging system

J 2018

Tumor grade as significant prognostic factor in pancreatic cancer: validation of a novel TNMG staging system

HLAVSA, Jan, F. CECKA, P. ZARUBA, J. ZAJAK, R. GURLICH et. al.

Základní údaje

Originální název

Tumor grade as significant prognostic factor in pancreatic cancer: validation of a novel TNMG staging system

Autoři

HLAVSA, Jan (203 Česká republika, domácí), F. CECKA (203 Česká republika), P. ZARUBA (203 Česká republika), J. ZAJAK (203 Česká republika), R. GURLICH (203 Česká republika), R. STRNAD (203 Česká republika), Tomáš PAVLÍK (203 Česká republika, domácí), Zdeněk KALA (203 Česká republika, domácí) a M. LOVECEK (203 Česká republika, garant)

Vydání

Neoplasma, Bratislava, Slovenská akademie vied, 2018, 0028-2685

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.771

Kód RIV

RIV/00216224:14110/18:00106969

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.4149/neo_2018_171012N650

UT WoS

000440172400019

Klíčová slova anglicky

pancreatic cancer; grade; TNM classification; prognosis

Štítky

14110223, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 2. 2019 16:49, Soňa Böhmová

Anotace

V originále

Aim of the study was to asses the tumor grade prognostic value in the Czech pancreatic cancer patients and to evaluate the accuracy of TNMG prognostic model. Retrospective analysis of 431 pancreatic cancer patients undergoing pancreatic resection in seven Czech oncological centers between 2003 and 2013 was performed. The impact of tumor grade and the accuracy of TNMG prognostic model were evaluated. Lymph node status, tumor size, tumor stage and grade were proved as statistically significant survival predictors. The lower tumor differentiation (grade 3 and 4) was associated with poorer prognosis in all stages (stage I: HR 2.23 [1.14; 4.36, CI 95%] p=0.019, stage II: HR 3.09 [2.01; 4.77, CI 95%] p=0.001, stage III and IV: HR 3.52 [1.73; 7.18, CI 95%] p=0.001). Kaplan-Meier analysis verified statistically significant impact of new TNMG stages on survival after resection for pancreatic cancer (p=0.001). In conclusion, we can state that the tumor grade was confirmed as statistically significant prognostic factor in pancreatic cancer. Its incorporation into the current TNM classification enables more accurate prognosis prediction within particular clinical stages. That is why an inclusion of the grade to the standard TNM classification should be discussed.

Návaznosti

NV16-31314A, projekt VaV

Název: Identifikace cirkulujících mikroRNA umožňujících prognostickou stratifikaci a selekci pacientů nejvíce profitujících z chirurgické léčby

Citovat

HLAVSA, Jan, F. CECKA, P. ZARUBA, J. ZAJAK, R. GURLICH, R. STRNAD, Tomáš PAVLÍK, Zdeněk KALA a M. LOVECEK. Tumor grade as significant prognostic factor in pancreatic cancer: validation of a novel TNMG staging system. Neoplasma. Bratislava: Slovenská akademie vied, 2018, roč. 65, č. 4, s. 637-643. ISSN 0028-2685. Dostupné z: https://dx.doi.org/10.4149/neo_2018_171012N650.

@article{1494147,
   author = {Hlavsa, Jan and Cecka, F. and Zaruba, P. and Zajak, J. and Gurlich, R. and Strnad, R. and Pavlík, Tomáš and Kala, Zdeněk and Lovecek, M.},
   article_location = {Bratislava},
   article_number = {4},
   doi = {http://dx.doi.org/10.4149/neo_2018_171012N650},
   keywords = {pancreatic cancer; grade; TNM classification; prognosis},
   language = {eng},
   issn = {0028-2685},
   journal = {Neoplasma},
   title = {Tumor grade as significant prognostic factor in pancreatic cancer: validation of a novel TNMG staging system},
   volume = {65},
   year = {2018}
}

TY  - JOUR
ID  - 1494147
AU  - Hlavsa, Jan - Cecka, F. - Zaruba, P. - Zajak, J. - Gurlich, R. - Strnad, R. - Pavlík, Tomáš - Kala, Zdeněk - Lovecek, M.
PY  - 2018
TI  - Tumor grade as significant prognostic factor in pancreatic cancer: validation of a novel TNMG staging system
JF  - Neoplasma
VL  - 65
IS  - 4
SP  - 637-643
EP  - 637-643
PB  - Slovenská akademie vied
SN  - 00282685
KW  - pancreatic cancer
KW  - grade
KW  - TNM classification
KW  - prognosis
N2  - Aim of the study was to asses the tumor grade prognostic value in the Czech pancreatic cancer patients and to evaluate the accuracy of TNMG prognostic model. Retrospective analysis of 431 pancreatic cancer patients undergoing pancreatic resection in seven Czech oncological centers between 2003 and 2013 was performed. The impact of tumor grade and the accuracy of TNMG prognostic model were evaluated. Lymph node status, tumor size, tumor stage and grade were proved as statistically significant survival predictors. The lower tumor differentiation (grade 3 and 4) was associated with poorer prognosis in all stages (stage I: HR 2.23 [1.14; 4.36, CI 95%] p=0.019, stage II: HR 3.09 [2.01; 4.77, CI 95%] p=0.001, stage III and IV: HR 3.52 [1.73; 7.18, CI 95%] p=0.001). Kaplan-Meier analysis verified statistically significant impact of new TNMG stages on survival after resection for pancreatic cancer (p=0.001). In conclusion, we can state that the tumor grade was confirmed as statistically significant prognostic factor in pancreatic cancer. Its incorporation into the current TNM classification enables more accurate prognosis prediction within particular clinical stages. That is why an inclusion of the grade to the standard TNM classification should be discussed.
ER  -

HLAVSA, Jan, F. CECKA, P. ZARUBA, J. ZAJAK, R. GURLICH, R. STRNAD, Tomáš PAVLÍK, Zdeněk KALA a M. LOVECEK. Tumor grade as significant prognostic factor in pancreatic cancer: validation of a novel TNMG staging system. \textit{Neoplasma}. Bratislava: Slovenská akademie vied, 2018, roč.~65, č.~4, s.~637-643. ISSN~0028-2685. Dostupné z: https://dx.doi.org/10.4149/neo\_{}2018\_{}171012N650.

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