Development of Policy Relevant Human Biomonitoring Indicators
for Chemical Exposure in the European Population

J 2018

Development of Policy Relevant Human Biomonitoring Indicators for Chemical Exposure in the European Population

BUEKERS, Jurgen, Madlen DAVID, Gudrun KOPPEN, Jos BESSEMS, Martin SCHERINGER et. al.

Základní údaje

Originální název

Development of Policy Relevant Human Biomonitoring Indicators for Chemical Exposure in the European Population

Autoři

BUEKERS, Jurgen (56 Belgie), Madlen DAVID (276 Německo), Gudrun KOPPEN (56 Belgie), Jos BESSEMS (56 Belgie), Martin SCHERINGER (756 Švýcarsko, garant, domácí), Erik LEBRET (528 Nizozemské království), Denis SARIGIANNIS (300 Řecko), Marike KOLOSSA-GEHRING (276 Německo), Marika BERGLUND (752 Švédsko), Greet SCHOETERS (56 Belgie) a Xenia TRIER (208 Dánsko)

Vydání

International Journal of Environmental Research and Public Health, BASEL, Molecular Diversity Preservation International, 2018, 1660-4601

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30304 Public and environmental health

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.468

Kód RIV

RIV/00216224:14310/18:00106137

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.3390/ijerph15102085

UT WoS

000448818100027

Klíčová slova anglicky

indicator; human biomonitoring; HBM; science-policy translation; HBM4EU; health-based guidance value; groups of substances

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 2. 2019 17:26, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

The European Union's 7th Environmental Action Programme (EAP) aims to assess and minimize environmental health risks from the use of hazardous chemicals by 2020. From this angle, policy questions like whether an implemented policy to reduce chemical exposure has had an effect over time, whether the health of people in specific regions or subpopulations is at risk, or whether the body burden of chemical substances (the internal exposure) varies with, for example, time, country, sex, age, or socio-economic status, need to be answered. Indicators can help to synthesize complex scientific information into a few key descriptors with the purpose of providing an answer to a non-expert audience. Human biomonitoring (HBM) indicators at the European Union (EU) level are unfortunately lacking. Within the Horizon2020 European Human Biomonitoring project HBM4EU, an approach to develop European HBM indicators was worked out. To learn from and ensure interoperability with other European indicators, 15 experts from the HBM4EU project (German Umweltbundesamt (UBA), Flemish research institute VITO, University of Antwerp, European Environment Agency (EEA)), and the World Health Organization (WHO), European Core Health Indicator initiative (ECHI), Eurostat, Swiss ETH Zurich and the Czech environmental institute CENIA, joined and contributed to a workshop, held in June 2017 at the EEA in Copenhagen. First, selection criteria were defined to evaluate when and if results of internal chemical exposure measured by HBM, need to be translated into a European HBM-based indicator. Two main aspects are the HBM indicator's relevance for policy, society, health, and the quality of the biomarker data (availability, comparability, ease of interpretation). Secondly, an approach for the calculation of the indicators was designed. Two types of indicators were proposed: '(sum) indicator(s) of internal exposure' derived directly from HBM biomarker concentrations and 'indicators for health risk', comparing HBM concentrations to HBM health-based guidance values (HBM HBGVs). In the latter case, both the percentage of the studied population exceeding the HBM HBGVs (PE) and the extent of exceedance (EE), calculated as the population's exposure level divided by the HBM HBGV, can be calculated. These indicators were applied to two examples of hazardous chemicals: bisphenol A (BPA) and per- and polyfluoroalkyl substances (PFASs), which both have high policy and societal relevance and for which high quality published data were available (DEMOCOPHES, Swedish monitoring campaign). European HBM indicators help to summarize internal exposure to chemical substances among the European population and communicate to what degree environmental policies are successful in keeping internal exposures sufficiently low. The main aim of HBM indicators is to allow follow-up of chemical safety in Europe.

Návaznosti

733032, interní kód MU

Název: European Human Biomonitoring Initiative (Akronym: HBM4EU)

Investor: Evropská unie, European Human Biomonitoring Initiative, Health, demographic change and wellbeing (Societal Challenges)

Citovat

BUEKERS, Jurgen, Madlen DAVID, Gudrun KOPPEN, Jos BESSEMS, Martin SCHERINGER, Erik LEBRET, Denis SARIGIANNIS, Marike KOLOSSA-GEHRING, Marika BERGLUND, Greet SCHOETERS a Xenia TRIER. Development of Policy Relevant Human Biomonitoring Indicators for Chemical Exposure in the European Population. International Journal of Environmental Research and Public Health. BASEL: Molecular Diversity Preservation International, 2018, roč. 15, č. 10, s. 1-18. ISSN 1660-4601. Dostupné z: https://dx.doi.org/10.3390/ijerph15102085.

@article{1495477,
   author = {Buekers, Jurgen and David, Madlen and Koppen, Gudrun and Bessems, Jos and Scheringer, Martin and Lebret, Erik and Sarigiannis, Denis and KolossaandGehring, Marike and Berglund, Marika and Schoeters, Greet and Trier, Xenia},
   article_location = {BASEL},
   article_number = {10},
   doi = {http://dx.doi.org/10.3390/ijerph15102085},
   keywords = {indicator; human biomonitoring; HBM; science-policy translation; HBM4EU; health-based guidance value; groups of substances},
   language = {eng},
   issn = {1660-4601},
   journal = {International Journal of Environmental Research and Public Health},
   title = {Development of Policy Relevant Human Biomonitoring Indicators for Chemical Exposure in the European Population},
   url = {https://www.mdpi.com/1660-4601/15/10/2085},
   volume = {15},
   year = {2018}
}

TY  - JOUR
ID  - 1495477
AU  - Buekers, Jurgen - David, Madlen - Koppen, Gudrun - Bessems, Jos - Scheringer, Martin - Lebret, Erik - Sarigiannis, Denis - Kolossa-Gehring, Marike - Berglund, Marika - Schoeters, Greet - Trier, Xenia
PY  - 2018
TI  - Development of Policy Relevant Human Biomonitoring Indicators for Chemical Exposure in the European Population
JF  - International Journal of Environmental Research and Public Health
VL  - 15
IS  - 10
SP  - 1-18
EP  - 1-18
PB  - Molecular Diversity Preservation International
SN  - 16604601
KW  - indicator
KW  - human biomonitoring
KW  - HBM
KW  - science-policy translation
KW  - HBM4EU
KW  - health-based guidance value
KW  - groups of substances
UR  - https://www.mdpi.com/1660-4601/15/10/2085
L2  - https://www.mdpi.com/1660-4601/15/10/2085
N2  - The European Union's 7th Environmental Action Programme (EAP) aims to assess and minimize environmental health risks from the use of hazardous chemicals by 2020. From this angle, policy questions like whether an implemented policy to reduce chemical exposure has had an effect over time, whether the health of people in specific regions or subpopulations is at risk, or whether the body burden of chemical substances (the internal exposure) varies with, for example, time, country, sex, age, or socio-economic status, need to be answered. Indicators can help to synthesize complex scientific information into a few key descriptors with the purpose of providing an answer to a non-expert audience. Human biomonitoring (HBM) indicators at the European Union (EU) level are unfortunately lacking. Within the Horizon2020 European Human Biomonitoring project HBM4EU, an approach to develop European HBM indicators was worked out. To learn from and ensure interoperability with other European indicators, 15 experts from the HBM4EU project (German Umweltbundesamt (UBA), Flemish research institute VITO, University of Antwerp, European Environment Agency (EEA)), and the World Health Organization (WHO), European Core Health Indicator initiative (ECHI), Eurostat, Swiss ETH Zurich and the Czech environmental institute CENIA, joined and contributed to a workshop, held in June 2017 at the EEA in Copenhagen. First, selection criteria were defined to evaluate when and if results of internal chemical exposure measured by HBM, need to be translated into a European HBM-based indicator. Two main aspects are the HBM indicator's relevance for policy, society, health, and the quality of the biomarker data (availability, comparability, ease of interpretation). Secondly, an approach for the calculation of the indicators was designed. Two types of indicators were proposed: '(sum) indicator(s) of internal exposure' derived directly from HBM biomarker concentrations and 'indicators for health risk', comparing HBM concentrations to HBM health-based guidance values (HBM HBGVs). In the latter case, both the percentage of the studied population exceeding the HBM HBGVs (PE) and the extent of exceedance (EE), calculated as the population's exposure level divided by the HBM HBGV, can be calculated. These indicators were applied to two examples of hazardous chemicals: bisphenol A (BPA) and per- and polyfluoroalkyl substances (PFASs), which both have high policy and societal relevance and for which high quality published data were available (DEMOCOPHES, Swedish monitoring campaign). European HBM indicators help to summarize internal exposure to chemical substances among the European population and communicate to what degree environmental policies are successful in keeping internal exposures sufficiently low. The main aim of HBM indicators is to allow follow-up of chemical safety in Europe.
ER  -

BUEKERS, Jurgen, Madlen DAVID, Gudrun KOPPEN, Jos BESSEMS, Martin SCHERINGER, Erik LEBRET, Denis SARIGIANNIS, Marike KOLOSSA-GEHRING, Marika BERGLUND, Greet SCHOETERS a Xenia TRIER. Development of Policy Relevant Human Biomonitoring Indicators for Chemical Exposure in the European Population. \textit{International Journal of Environmental Research and Public Health}. BASEL: Molecular Diversity Preservation International, 2018, roč.~15, č.~10, s.~1-18. ISSN~1660-4601. Dostupné z: https://dx.doi.org/10.3390/ijerph15102085.

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