2018
Natural selection in bats with historical exposure to white-nose syndrome
HARAZIM, Markéta, Ivan HORACEK, Lucie JAKEŠOVÁ, Kristína LUERMANN, Jiri C MORAVEC et. al.Základní údaje
Originální název
Natural selection in bats with historical exposure to white-nose syndrome
Autoři
HARAZIM, Markéta (203 Česká republika, domácí), Ivan HORACEK, Lucie JAKEŠOVÁ (203 Česká republika, domácí), Kristína LUERMANN (703 Slovensko, domácí), Jiri C MORAVEC, Shannon MORGAN, Jiří PIKULA (203 Česká republika), Petr SOSIK, Zuzana VAVRUSOVA, Alexandra Jr. ZAHRADNÍKOVÁ, Jan ZUKAL (203 Česká republika, domácí) a Natália MARTÍNKOVÁ (703 Slovensko, garant, domácí)
Vydání
BMC Zoology, London, BioMed Central, 2018, 2056-3132
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
10602 Biology , Evolutionary biology
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Kód RIV
RIV/00216224:14310/18:00109157
Organizační jednotka
Přírodovědecká fakulta
UT WoS
000445835700001
Klíčová slova anglicky
Skin; Fungal infection; Wound healing; Immunity; Gene evolution
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 5. 8. 2020 11:03, doc. Mgr. Natália Martínková, Ph.D.
Anotace
V originále
Hibernation allows animals to survive periods of resource scarcity by reducing their energy expenditure through decreased metabolism. However, hibernators become susceptible to psychrophilic pathogens if they cannot mount an efficient immune response to infection. While Nearctic bats infected with white-nose syndrome (WNS) suffer high mortality, related Palearctic taxa are better able to survive the disease than their Nearctic counterparts. We hypothesised that WNS exerted historical selective pressure in Palearctic bats, resulting in genomic changes that promote infection tolerance.Results: We investigated partial sequences of 23 genes related to water metabolism and skin structure function in nine Palearctic and Nearctic hibernating bat species and one non-hibernating species for phylogenetic signals of natural selection. Using maximum likelihood analysis, we found that eight genes were under positive selection and we successfully identified amino acid sites under selection in five encoded proteins. Branch site models revealed positive selection in three genes. Hibernating bats exhibit signals for positive selection in genes ensuring tissue regeneration, wound healing and modulation of the immune response.Conclusion: Our results highlight the importance of skin barrier integrity and healing capacity in hibernating bats. The protective role of skin integrity against both pathophysiology and WNS progression, in synergy with down regulation of the immune reaction in response to the Pseudogymnoascus destructans infection, improves host survival. Our data also suggest that hibernating bat species have evolved into tolerant hosts by reducing the negative impact of skin infection through a set of adaptations, including those at the genomic level.