J 2018

Synthetic osmotic dilators in the induction of labour-An international multicentre observational study

GUPTA, Janesh, Rohan CHODANKAR, Oleg BAEV, Franz BAHLMANN, Eugen BREGA et. al.

Základní údaje

Originální název

Synthetic osmotic dilators in the induction of labour-An international multicentre observational study

Autoři

GUPTA, Janesh (826 Velká Británie a Severní Irsko), Rohan CHODANKAR (826 Velká Británie a Severní Irsko, garant), Oleg BAEV (643 Rusko), Franz BAHLMANN (276 Německo), Eugen BREGA (643 Rusko), Anisha GALA (356 Indie), Lars HELLMEYER (276 Německo), Lukáš HRUBAN (203 Česká republika, domácí), Josefine MAIER (276 Německo), Priyanka MEHTA (356 Indie), Amitasrigowri MURTHY (840 Spojené státy), Melanie RITTER (276 Německo), Antonio SAAD (840 Spojené státy), Roman SHMAKOV (643 Rusko), Amita SUNEJA (356 Indie), Jozef ZAHUMENSKY (703 Slovensko) a Daniela GDOVINOVA (203 Česká republika)

Vydání

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, AMSTERDAM, ELSEVIER SCIENCE BV, 2018, 0301-2115

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.024

Kód RIV

RIV/00216224:14110/18:00106424

Organizační jednotka

Lékařská fakulta

DOI

UT WoS

000447557200011

Klíčová slova anglicky

Cervical ripening; Dilapan-S; Induction of labour; Synthetic osmotic dilators; Pregnancy; Birth

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 1. 3. 2019 16:01, Soňa Böhmová

Anotace

V originále

Introduction: To evaluate the effects of synthetic osmotic dilators (Dilapan-S/Dilasoft) in women who required induction of labour in a large prospective multicentre international observational study. Materials and methods: Primary outcomes were duration of Dilapan-S/Dilasoft insertion (hours), total induction - delivery interval (hours) and the rate of vaginal deliveries within 24h (%). Secondary outcomes were the number of dilators inserted, Bishop score increase after extraction of Dilapan-S/Dilasoft, complications during induction (uterine contractions, uterine tachysystole and hyperstimulation, effect on the fetus) and post induction (infections and neonatal outcomes), agents / procedures used for subsequent induction of labour, immediate rate of spontaneous labours following cervical ripening period, rate of spontaneous vaginal deliveries, rate of instrumental vaginal deliveries and caesarean sections. RESULTS: Total of 543 women were recruited across 11 study sites, of which, 444 women were eligible for analysis. With Dilapan-S/Dilasoft use of <12 h (n =188) the overall vaginal delivery rate was 76.6% with 45.7% of these births occurring within 24 h, 66% within 36 h and 75.5% within 48 h from insertion of Dilapan-S/Dilasoft. The mean insertion-delivery interval for this group was 24.3(+/- 10.4) hours. With Dilapan-S/Dilasoft use of >12 h (n = 256), the overall vaginal delivery rate was 64.8%, with 16% of these births occurring within 24 h, 48.4% within 36 h and 54.7% within 48 h from insertion of Dilapan-S/Dilasoft. The mean insertion-delivery interval for this group was 39.1(+/- 29.2) hours. The mean gain in the Bishops score was +3.6(+/- 2.3). The mean number of Dilapan-S/Dilasoft dilators used was 3.8 (+/- 1.1). The overall rate of caesarean section was 30.1%. The overall complication rate was low including infection risk. No adverse neonatal outcome was attributable to the use of Dilapan-S/Dilaso Conclusion: Dilapan-S/Dilasoft are safe and effective methods for cervical ripening. Their use is associated with low maternal and neonatal complication rates. Future research should aim at level clinical trials comparing Dilapan-S to other mechanical or pharmacological cervical ripening agents. (C) 2018 Elsevier B.V. All rights reserved.