MAZURENKO, Stanislav, Jan ŠTOURAČ, Antonín KUNKA, S. NEDELJKOVIC, David BEDNÁŘ, Zbyněk PROKOP a Jiří DAMBORSKÝ. CalFitter: a web server for analysis of protein thermal denaturation data. Nucleic Acids Research. Oxford: Oxford University Press, 2018, roč. 46, W1, s. "W344"-"W349", 6 s. ISSN 0305-1048. Dostupné z: https://dx.doi.org/10.1093/nar/gky358. |
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@article{1503349, author = {Mazurenko, Stanislav and Štourač, Jan and Kunka, Antonín and Nedeljkovic, S. and Bednář, David and Prokop, Zbyněk and Damborský, Jiří}, article_location = {Oxford}, article_number = {W1}, doi = {http://dx.doi.org/10.1093/nar/gky358}, keywords = {DIFFERENTIAL SCANNING CALORIMETRY; THEORETICAL-ANALYSIS; STABILITY; STATE; TEMPERATURE; 3-STATE; ENZYME; RATES}, language = {eng}, issn = {0305-1048}, journal = {Nucleic Acids Research}, title = {CalFitter: a web server for analysis of protein thermal denaturation data}, url = {https://loschmidt.chemi.muni.cz/peg/category/publications/#2018}, volume = {46}, year = {2018} }
TY - JOUR ID - 1503349 AU - Mazurenko, Stanislav - Štourač, Jan - Kunka, Antonín - Nedeljkovic, S. - Bednář, David - Prokop, Zbyněk - Damborský, Jiří PY - 2018 TI - CalFitter: a web server for analysis of protein thermal denaturation data JF - Nucleic Acids Research VL - 46 IS - W1 SP - "W344"-"W349" EP - "W344"-"W349" PB - Oxford University Press SN - 03051048 KW - DIFFERENTIAL SCANNING CALORIMETRY KW - THEORETICAL-ANALYSIS KW - STABILITY KW - STATE KW - TEMPERATURE KW - 3-STATE KW - ENZYME KW - RATES UR - https://loschmidt.chemi.muni.cz/peg/category/publications/#2018 N2 - Despite significant advances in the understanding of protein structure-function relationships, revealing protein folding pathways still poses a challenge due to a limited number of relevant experimental tools. Widely-used experimental techniques, such as calorimetry or spectroscopy, critically depend on a proper data analysis. Currently, there are only separate data analysis tools available for each type of experiment with a limited model selection. To address this problem, we have developed the CalFitter web server to be a unified platform for comprehensive data fitting and analysis of protein thermal denaturation data. The server allows simultaneous global data fitting using any combination of input data types and offers 12 protein unfolding pathway models for selection, including irreversible transitions often missing from other tools. The data fitting produces optimal parameter values, their confidence intervals, and statistical information to define unfolding pathways. The server provides an interactive and easy-to-use interface that allows users to directly analyse input datasets and simulate modelled output based on the model parameters. ER -
MAZURENKO, Stanislav, Jan ŠTOURAČ, Antonín KUNKA, S. NEDELJKOVIC, David BEDNÁŘ, Zbyněk PROKOP a Jiří DAMBORSKÝ. CalFitter: a web server for analysis of protein thermal denaturation data. \textit{Nucleic Acids Research}. Oxford: Oxford University Press, 2018, roč.~46, W1, s.~''W344''-''W349'', 6 s. ISSN~0305-1048. Dostupné z: https://dx.doi.org/10.1093/nar/gky358.
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