| ROHDE, Christine, Grégory RESCH, Jean-Paul PIRNAY, Bob G. BLASDEL, Laurent DEBARBIEUX, Daniel GELMAN, Andrej GORSKI, Ronen HAZAN, Isabelle HUYS, Elene KAKABADZE, Małgorzata ŁOBOCKA, Alice MAESTRI, Gabriel Magno de Freitas ALMEIDA, Khatuna MAKALATIA, Danish J. MALIK, Ivana MAŠLAŇOVÁ, Maia MERABISHVILI, Roman PANTŮČEK, Thomas ROSE, Dana ŠTVERÁKOVÁ, Hilde VAN RAEMDONCK, Gilbert VERBEKEN a Nina CHANISHVILI. Expert opinion on three phage therapy related topics: Bacterial phage resistance, phage training and prophages in bacterial production strains. VIRUSES-BASEL. BASEL: MDPI AG, 2018, roč. 10, č. 4, s. 178-192. ISSN 1999-4915. Dostupné z: https://dx.doi.org/10.3390/v10040178. |
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@article{1503382,
author = {Rohde, Christine and Resch, Grégory and Pirnay, JeanandPaul and Blasdel, Bob G. and Debarbieux, Laurent and Gelman, Daniel and Gorski, Andrej and Hazan, Ronen and Huys, Isabelle and Kakabadze, Elene and Łobocka, Małgorzata and Maestri, Alice and Almeida, Gabriel Magno de Freitas and Makalatia, Khatuna and Malik, Danish J. and Mašlaňová, Ivana and Merabishvili, Maia and Pantůček, Roman and Rose, Thomas and Štveráková, Dana and Van Raemdonck, Hilde and Verbeken, Gilbert and Chanishvili, Nina},
article_location = {BASEL},
article_number = {4},
doi = {http://dx.doi.org/10.3390/v10040178},
keywords = {Bacteriophage; phage therapy; resistance; adaptation; prophage; production; regulation},
language = {eng},
issn = {1999-4915},
journal = {VIRUSES-BASEL},
title = {Expert opinion on three phage therapy related topics: Bacterial phage resistance, phage training and prophages in bacterial production strains},
url = {https://www.mdpi.com/1999-4915/10/4/178},
volume = {10},
year = {2018}
}
TY - JOUR
ID - 1503382
AU - Rohde, Christine - Resch, Grégory - Pirnay, Jean-Paul - Blasdel, Bob G. - Debarbieux, Laurent - Gelman, Daniel - Gorski, Andrej - Hazan, Ronen - Huys, Isabelle - Kakabadze, Elene - Łobocka, Małgorzata - Maestri, Alice - Almeida, Gabriel Magno de Freitas - Makalatia, Khatuna - Malik, Danish J. - Mašlaňová, Ivana - Merabishvili, Maia - Pantůček, Roman - Rose, Thomas - Štveráková, Dana - Van Raemdonck, Hilde - Verbeken, Gilbert - Chanishvili, Nina
PY - 2018
TI - Expert opinion on three phage therapy related topics: Bacterial phage resistance, phage training and prophages in bacterial production strains
JF - VIRUSES-BASEL
VL - 10
IS - 4
SP - 178
EP - 178
PB - MDPI AG
SN - 19994915
KW - Bacteriophage
KW - phage therapy
KW - resistance
KW - adaptation
KW - prophage
KW - production
KW - regulation
UR - https://www.mdpi.com/1999-4915/10/4/178
L2 - https://www.mdpi.com/1999-4915/10/4/178
N2 - Phage therapy is increasingly put forward as a "new" potential tool in the fight against antibiotic resistant infections. During the "Centennial Celebration of Bacteriophage Research" conference in Tbilisi, Georgia on 26-29 June 2017, an international group of phage researchers committed to elaborate an expert opinion on three contentious phage therapy related issues that are hampering clinical progress in the field of phage therapy. This paper explores and discusses bacterial phage resistance, phage training and the presence of prophages in bacterial production strains while reviewing relevant research findings and experiences. Our purpose is to inform phage therapy stakeholders such as policy makers, officials of the competent authorities for medicines, phage researchers and phage producers, and members of the pharmaceutical industry. This brief also points out potential avenues for future phage therapy research and development as it specifically addresses those overarching questions that currently call for attention whenever phages go into purification processes for application.
ER -
ROHDE, Christine, Grégory RESCH, Jean-Paul PIRNAY, Bob G. BLASDEL, Laurent DEBARBIEUX, Daniel GELMAN, Andrej GORSKI, Ronen HAZAN, Isabelle HUYS, Elene KAKABADZE, Małgorzata ŁOBOCKA, Alice MAESTRI, Gabriel Magno de Freitas ALMEIDA, Khatuna MAKALATIA, Danish J. MALIK, Ivana MAŠLAŇOVÁ, Maia MERABISHVILI, Roman PANTŮČEK, Thomas ROSE, Dana ŠTVERÁKOVÁ, Hilde VAN RAEMDONCK, Gilbert VERBEKEN a Nina CHANISHVILI. Expert opinion on three phage therapy related topics: Bacterial phage resistance, phage training and prophages in bacterial production strains. \textit{VIRUSES-BASEL}. BASEL: MDPI AG, 2018, roč.~10, č.~4, s.~178-192. ISSN~1999-4915. Dostupné z: https://dx.doi.org/10.3390/v10040178.
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