Other formats:
BibTeX
LaTeX
RIS
@inbook{1503433,
author = {Brezovský, Jan and Kozlíková, Barbora and Damborský, Jiří},
address = {New York},
booktitle = {PROTEIN ENGINEERING. METHODS AND PROTOCOLS},
editor = {Editors: Bornscheuer, Uwe T., Höhne, Matthias},
keywords = {Binding; Protein; Tunnel; Channel; Gate; Rational design; Software; CAVER; Transport},
howpublished = {tištěná verze "print"},
language = {eng},
location = {New York},
isbn = {978-1-4939-7366-8},
pages = {25-42},
publisher = {Springer},
title = {Computational Analysis of Protein Tunnels and Channels},
url = {https://loschmidt.chemi.muni.cz/peg/wp-content/uploads/2017/11/book17_brezovsky.pdf},
year = {2017}
}
TY - CHAP
ID - 1503433
AU - Brezovský, Jan - Kozlíková, Barbora - Damborský, Jiří
PY - 2017
TI - Computational Analysis of Protein Tunnels and Channels
VL - neuveden pro RIV
PB - Springer
CY - New York
SN - 9781493973668
KW - Binding
KW - Protein
KW - Tunnel
KW - Channel
KW - Gate
KW - Rational design
KW - Software
KW - CAVER
KW - Transport
UR - https://loschmidt.chemi.muni.cz/peg/wp-content/uploads/2017/11/book17_brezovsky.pdf
N2 - Protein tunnels connecting the functional buried cavities with bulk solvent and protein channels, enabling the transport through biological membranes, represent the structural features that govern the exchange rates of ligands, ions, and water solvent. Tunnels and channels are present in a vast number of known proteins and provide control over their function. Modification of these structural features by protein engineering frequently provides proteins with improved properties. Here we present a detailed computational protocol employing the CAVER software that is applicable for: (1) the analysis of tunnels and channels in protein structures, and (2) the selection of hot-spot residues in tunnels or channels that can be mutagenized for improved activity, specificity, enantioselectivity, or stability
ER -
BREZOVSKÝ, Jan, Barbora KOZLÍKOVÁ and Jiří DAMBORSKÝ. Computational Analysis of Protein Tunnels and Channels. In Editors: Bornscheuer, Uwe T., Höhne, Matthias. \textit{PROTEIN ENGINEERING. METHODS AND PROTOCOLS}. New York: Springer, 2017, p.~25-42. ISBN~978-1-4939-7366-8.
|
