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@article{1503516,
author = {Dvořáčková, Milada and Růžička, Filip and Benešík, Martin and Pantůček, Roman and Dvořáková Heroldová, Monika},
article_location = {Dordrecht},
article_number = {1},
doi = {http://dx.doi.org/10.1007/s12223-018-0622-3},
keywords = {Staphylococcus; MRSA; biofilm; phage therapy; Kayvirus; Stafal; Myoviridae},
language = {eng},
issn = {0015-5632},
journal = {Folia microbiologica},
title = {Antimicrobial effect of commercial phage preparation Stafal (R) on biofilm and planktonic forms of methicillin-resistant Staphylococcus aureus},
url = {https://link.springer.com/article/10.1007%2Fs12223-018-0622-3},
volume = {64},
year = {2019}
}
TY - JOUR
ID - 1503516
AU - Dvořáčková, Milada - Růžička, Filip - Benešík, Martin - Pantůček, Roman - Dvořáková Heroldová, Monika
PY - 2019
TI - Antimicrobial effect of commercial phage preparation Stafal (R) on biofilm and planktonic forms of methicillin-resistant Staphylococcus aureus
JF - Folia microbiologica
VL - 64
IS - 1
SP - 121-126
EP - 121-126
PB - Springer
SN - 00155632
KW - Staphylococcus
KW - MRSA
KW - biofilm
KW - phage therapy
KW - Kayvirus
KW - Stafal
KW - Myoviridae
UR - https://link.springer.com/article/10.1007%2Fs12223-018-0622-3
L2 - https://link.springer.com/article/10.1007%2Fs12223-018-0622-3
N2 - Staphylococcus aureus may be a highly virulent human pathogen, especially when it is able to form a biofilm, and it is resistant to antibiotic. Infections caused by these bacteria significantly affect morbidity and mortality, primarily in hospitalized patients. Treatment becomes more expensive, more toxic, and prolonged. This is the reason why research on alternative therapies should be one of the main priorities of medicine and biotechnology. A promising alternative treatment approach is bacteriophage therapy. The effect of the anti-staphylococcal bacteriophage preparation Stafal (R) on biofilm reduction was assessed on nine S. aureus strains using both sonication with subsequent quantification of surviving cells on the catheter surface and evaluation of biofilm reduction in microtiter plates. It was demonstrated that the bacteriophages destroy planktonic cells very effectively. However, to destroy cells embedded in the biofilm effectively requires a concentration at least ten times higher than that provided by the commercial preparation. The catheter disc method (CDM) allowed easier comparison of the effect on planktonic cells and cells in a biofilm than the microtiter plate (MTP) method.
ER -
DVOŘÁČKOVÁ, Milada, Filip RŮŽIČKA, Martin BENEŠÍK, Roman PANTŮČEK and Monika DVOŘÁKOVÁ HEROLDOVÁ. Antimicrobial effect of commercial phage preparation Stafal (R) on biofilm and planktonic forms of methicillin-resistant Staphylococcus aureus. \textit{Folia microbiologica}. Dordrecht: Springer, 2019, vol.~64, No~1, p.~121-126. ISSN~0015-5632. Available from: https://dx.doi.org/10.1007/s12223-018-0622-3.
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