| REMŠÍK, Ján, Lucia BINÓ, zuzana KAHOUNOVÁ, Gvantsa KHARAISHVILI, Šárka ŠIMEČKOVÁ, Radek FEDR, Tereza KUČÍRKOVÁ, Sára LENÁRT, Ximena Maria MURESAN, Eva SLABÁKOVÁ, Lucia KNOPFOVÁ, Jan BOUCHAL, Milan KRÁL, Petr BENEŠ and Karel SOUČEK. Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition. Carcinogenesis. OXFORD UNIV PRESS, 2018, vol. 39, No 11, p. 1411-1418. ISSN 0143-3334. Available from: https://dx.doi.org/10.1093/carcin/bgy095. |
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@article{1503958,
author = {Remšík, Ján and Binó, Lucia and Kahounová, zuzana and Kharaishvili, Gvantsa and Šimečková, Šárka and Fedr, Radek and Kučírková, Tereza and Lenárt, Sára and Muresan, Ximena Maria and Slabáková, Eva and Knopfová, Lucia and Bouchal, Jan and Král, Milan and Beneš, Petr and Souček, Karel},
article_number = {11},
doi = {http://dx.doi.org/10.1093/carcin/bgy095},
keywords = {cancer plasticity; epithelial-to-mesenchymal transition; intratumoral heterogeneity; Trop-2},
language = {eng},
issn = {0143-3334},
journal = {Carcinogenesis},
title = {Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition},
url = {https://academic.oup.com/carcin/article-abstract/39/11/1411/5054274?redirectedFrom=fulltext},
volume = {39},
year = {2018}
}
TY - JOUR
ID - 1503958
AU - Remšík, Ján - Binó, Lucia - Kahounová, zuzana - Kharaishvili, Gvantsa - Šimečková, Šárka - Fedr, Radek - Kučírková, Tereza - Lenárt, Sára - Muresan, Ximena Maria - Slabáková, Eva - Knopfová, Lucia - Bouchal, Jan - Král, Milan - Beneš, Petr - Souček, Karel
PY - 2018
TI - Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition
JF - Carcinogenesis
VL - 39
IS - 11
SP - 1411-1418
EP - 1411-1418
PB - OXFORD UNIV PRESS
SN - 01433334
KW - cancer plasticity
KW - epithelial-to-mesenchymal transition
KW - intratumoral heterogeneity
KW - Trop-2
UR - https://academic.oup.com/carcin/article-abstract/39/11/1411/5054274?redirectedFrom=fulltext
N2 - The cell surface glycoprotein Trop-2 is commonly overexpressed in carcinomas and represents an exceptional antigen for targeted therapy. Here, we provide evidence that surface Trop-2 expression is functionally connected with an epithelial phenotype in breast and prostate cell lines and in patient tumor samples. We further show that Trop-2 expression is suppressed epigenetically or through the action of epithelial-to-mesenchymal transition transcription factors and that deregulation of Trop-2 expression is linked with cancer progression and poor patient prognosis. Moreover, our data suggest that the cancer plasticity-driven intratumoral heterogeneity in Trop-2 expression may significantly contribute to response and resistance to therapies targeting Trop-2-expressing cells.
ER -
REMŠÍK, Ján, Lucia BINÓ, zuzana KAHOUNOVÁ, Gvantsa KHARAISHVILI, Šárka ŠIMEČKOVÁ, Radek FEDR, Tereza KUČÍRKOVÁ, Sára LENÁRT, Ximena Maria MURESAN, Eva SLABÁKOVÁ, Lucia KNOPFOVÁ, Jan BOUCHAL, Milan KRÁL, Petr BENEŠ and Karel SOUČEK. Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition. \textit{Carcinogenesis}. OXFORD UNIV PRESS, 2018, vol.~39, No~11, p.~1411-1418. ISSN~0143-3334. Available from: https://dx.doi.org/10.1093/carcin/bgy095.
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