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@article{1505077,
author = {Liao, Q.H. and Owen, Michael Christopher and Bali, S. and Barz, B. and Strodel, B.},
article_location = {Cambridge},
article_number = {56},
doi = {http://dx.doi.org/10.1039/c8cc02263a},
keywords = {ALZHEIMERS-DISEASE; PROTEIN OLIGOMERS; FIBRIL FORMATION; AGGREGATION; TOXICITY; PATHWAYS; ASSEMBLIES; DYNAMICS; MONOMER; BINDING},
language = {eng},
issn = {1359-7345},
journal = {Chemical communications},
title = {A beta under stress: the effects of acidosis, Cu2+-binding, and oxidation on amyloid beta-peptide dimers},
url = {https://pubs.rsc.org/en/Content/ArticleLanding/2018/CC/C8CC02263A#!divAbstract},
volume = {54},
year = {2018}
}
TY - JOUR
ID - 1505077
AU - Liao, Q.H. - Owen, Michael Christopher - Bali, S. - Barz, B. - Strodel, B.
PY - 2018
TI - A beta under stress: the effects of acidosis, Cu2+-binding, and oxidation on amyloid beta-peptide dimers
JF - Chemical communications
VL - 54
IS - 56
SP - 7766-7769
EP - 7766-7769
PB - Royal Society of Chemistry
SN - 13597345
KW - ALZHEIMERS-DISEASE
KW - PROTEIN OLIGOMERS
KW - FIBRIL FORMATION
KW - AGGREGATION
KW - TOXICITY
KW - PATHWAYS
KW - ASSEMBLIES
KW - DYNAMICS
KW - MONOMER
KW - BINDING
UR - https://pubs.rsc.org/en/Content/ArticleLanding/2018/CC/C8CC02263A#!divAbstract
N2 - In light of the high affinity of Cu2+ for Alzheimer's A(1-42) and its ability to subsequently catalyze the formation of radicals, we examine the effects of Cu2+ binding, A oxidation, and an acidic environment on the conformational dynamics of the smallest A(1-42) oligomer, the A(1-42) dimer. Transition networks calculated from Hamiltonian replica exchange molecular dynamics (H-REMD) simulations reveal that the decreased pH considerably increased the -sheet content, whereas Cu2+ binding increased the exposed hydrophobic surface area, both of which can contribute to an increased oligomerization propensity and toxicity.
ER -
LIAO, Q.H., Michael Christopher OWEN, S. BALI, B. BARZ a B. STRODEL. A beta under stress: the effects of acidosis, Cu2+-binding, and oxidation on amyloid beta-peptide dimers. \textit{Chemical communications}. Cambridge: Royal Society of Chemistry, 2018, roč.~54, č.~56, s.~7766-7769. ISSN~1359-7345. Dostupné z: https://dx.doi.org/10.1039/c8cc02263a.
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