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@article{1505247,
author = {Owen, Michael Christopher and Kulig, W. and Rog, T. and Vattulainen, I. and Strodel, B.},
article_location = {NEW YORK},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s00232-018-0028-9},
keywords = {Lipid oxidation; Cholesterol protection; Oxidative stress; Oxidized membranes; Pore formation},
language = {eng},
issn = {0022-2631},
journal = {JOURNAL OF MEMBRANE BIOLOGY},
title = {Cholesterol Protects the Oxidized Lipid Bilayer from Water Injury: An All-Atom Molecular Dynamics Study},
volume = {251},
year = {2018}
}
TY - JOUR
ID - 1505247
AU - Owen, Michael Christopher - Kulig, W. - Rog, T. - Vattulainen, I. - Strodel, B.
PY - 2018
TI - Cholesterol Protects the Oxidized Lipid Bilayer from Water Injury: An All-Atom Molecular Dynamics Study
JF - JOURNAL OF MEMBRANE BIOLOGY
VL - 251
IS - 3
SP - 521-534
EP - 521-534
PB - SPRINGER
SN - 00222631
KW - Lipid oxidation
KW - Cholesterol protection
KW - Oxidative stress
KW - Oxidized membranes
KW - Pore formation
N2 - In an effort to delineate how cholesterol protects membrane structure under oxidative stress conditions, we monitored the changes to the structure of lipid bilayers comprising 30 mol% cholesterol and an increasing concentration of Class B oxidized 1-palmitoyl-2-oleoylphosphatidylcholine (POPC) glycerophospholipids, namely, 1-palmitoyl-2-(9'-oxo-nonanoyl)-sn-glycero-3-phosphocholine (PoxnoPC), and 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PazePC), using atomistic molecular dynamics simulations. Increasing the content of oxidized phospholipids (oxPLs) from 0 to 60 mol% oxPL resulted in a characteristic reduction in bilayer thickness and increase in area per lipid, thereby increasing the exposure of the membrane hydrophobic region to water. However, cholesterol was observed to help reduce water injury by moving into the bilayer core and forming more hydrogen bonds with the oxPLs. Cholesterol also resists altering its tilt angle, helping to maintain membrane integrity. Water that enters the 1-nm-thick core region remains part of the bulk water on either side of the bilayer, with relatively few water molecules able to traverse through the bilayer. In cholesterol-rich membranes, the bilayer does not form pores at concentrations of 60 mol% oxPL as was shown in previous simulations in the absence of cholesterol.
ER -
OWEN, Michael Christopher, W. KULIG, T. ROG, I. VATTULAINEN a B. STRODEL. Cholesterol Protects the Oxidized Lipid Bilayer from Water Injury: An All-Atom Molecular Dynamics Study. \textit{JOURNAL OF MEMBRANE BIOLOGY}. NEW YORK: SPRINGER, 2018, roč.~251, č.~3, s.~521-534. ISSN~0022-2631. Dostupné z: https://dx.doi.org/10.1007/s00232-018-0028-9.
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