2018
Functional Characterization of SMG7 Paralogs in Arabidopsis thaliana
CAPITAO, C., Neha SHUKLA, Aneta WANDROLOVÁ, O.M. SCHEID, Karel ŘÍHA et. al.Základní údaje
Originální název
Functional Characterization of SMG7 Paralogs in Arabidopsis thaliana
Autoři
CAPITAO, C. (40 Rakousko), Neha SHUKLA (356 Indie, domácí), Aneta WANDROLOVÁ (203 Česká republika, domácí), O.M. SCHEID (40 Rakousko) a Karel ŘÍHA (203 Česká republika, garant, domácí)
Vydání
Frontiers in Plant Science, Lausanne (Switzerland), Frontiers Media SA, 2018, 1664-462X
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
10611 Plant sciences, botany
Stát vydavatele
Švýcarsko
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 4.106
Kód RIV
RIV/00216224:14740/18:00101791
Organizační jednotka
Středoevropský technologický institut
UT WoS
000449282400001
Klíčová slova anglicky
nonsense mediated RNA decay; meiosis; SMG7; gene duplication; Arabidopsis
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 19. 3. 2019 14:38, Mgr. Pavla Foltynová, Ph.D.
Anotace
V originále
SMG7 proteins are evolutionary conserved across eukaryotes and primarily known for their function in nonsense mediated RNA decay (NMD). In contrast to other NMD factors, SMG7 proteins underwent independent expansions during evolution indicating their propensity to adopt novel functions. Here we characterized SMG7 and SMG7-like (SMG7L) paralogs in Arabidopsis thaliana. SMG7 retained its role in NMD and additionally appears to have acquired another function in meiosis. We inactivated SMG7 by CRISPR/Cas9 mutagenesis and showed that, in contrast to our previous report, SMG7 is not an essential gene in Arabidopsis. Furthermore, our data indicate that the N-terminal phosphoserine-binding domain is required for both NMD and meiosis. Phenotypic analysis of SMG7 and SMG7L double mutants did not indicate any functional redundancy between the two genes, suggesting neofunctionalization of SMG7L. Finally, protein sequence comparison together with a phenotyping of T-DNA insertion mutants identified several conserved regions specific for SMG7 that may underlie its role in NMD and meiosis. This information provides a framework for deciphering the non-canonical functions of SMG7-family proteins.
Návaznosti
EF15_003/0000479, projekt VaV |
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GA16-18578S, projekt VaV |
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