European trends in epilepsy surgery

J 2018

European trends in epilepsy surgery

BAUD, M.O., T. PERNEGER, A. RACZ, M.C. PENSEL, C. ELGER et. al.

Základní údaje

Originální název

European trends in epilepsy surgery

Autoři

BAUD, M.O. (756 Švýcarsko), T. PERNEGER (756 Švýcarsko), A. RACZ (276 Německo), M.C. PENSEL (276 Německo), C. ELGER (276 Německo), B. RYDENHAG (752 Švédsko), K. MALMGREN (752 Švédsko), J.H. CROSS (826 Velká Británie a Severní Irsko), G. MCKENNA (826 Velká Británie a Severní Irsko), M. TISDALL (826 Velká Británie a Severní Irsko), H.J. LAMBERINK (528 Nizozemské království), S. RHEIMS (528 Nizozemské království), P. RYVLIN (250 Francie), J. ISNARD (250 Francie), F. MAUGUIERE (250 Francie), A. ARZIMANOGLOU (250 Francie), S. AKKOL (792 Turecko), K. DENIZ (792 Turecko), C. OZKARA (792 Turecko), M. LOSSIUS (578 Norsko), Ivan REKTOR (203 Česká republika, garant, domácí), R. KALVIAINEN (246 Finsko), L.M. VANHATALO (246 Finsko), P. DIMOVA (100 Bulharsko), K. MINKIN (100 Bulharsko), A.M. STAACK (276 Německo), B.J. STEINHOFF (276 Německo), A. KALINA (203 Česká republika), P. KRSEK (203 Česká republika), P. MARUSIC (203 Česká republika), Z. JORDAN (348 Maďarsko), D. FABO (348 Maďarsko), E. CARRETTE (56 Belgie), P. BOON (56 Belgie), S. ROCKA (440 Litva), R. MAMENISKIENE (440 Litva), S. VULLIEMOZ (756 Švýcarsko), F. PITTAU (756 Švýcarsko), K.P.J. BRAUN (528 Nizozemské království) a M. SEECK (756 Švýcarsko)

Vydání

Neurology, Philadelphia, LIPPINCOTT WILLIAMS & WILKINS, 2018, 0028-3878

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 8.689

Kód RIV

RIV/00216224:14740/18:00106660

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1212/WNL.0000000000005776

UT WoS

000439337300001

Klíčová slova anglicky

TEMPORAL-LOBE EPILEPSY; UNITED-STATES; SURGICAL-TREATMENT; OUTCOMES; COMPLICATIONS; ASSOCIATION; RESECTIONS; CENTERS; ADULT; TRIAL

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 4. 2024 14:59, Mgr. Michal Petr

Anotace

V originále

Objective Resective surgery is effective in treating drug-resistant focal epilepsy, but it remains unclear whether improved diagnostics influence postsurgical outcomes. Here, we compared practice and outcomes over 2 periods 15 years apart. Methods Sixteen European centers retrospectively identified 2 cohorts of children and adults who underwent epilepsy surgery in the period of 1997 to 1998 (n = 562) or 2012 to 2013 (n = 736). Data collected included patient (sex, age) and disease (duration, localization and diagnosis) characteristics, type of surgery, histopathology, Engel postsurgical outcome, and complications, as well as imaging and electrophysiologic tests performed for each case. Postsurgical outcome predictors were included in a multivariate logistic regression to assess the strength of date of surgery as an independent predictor. Results Over time, the number of operated cases per center increased from a median of 31 to 50 per 2-year period (p = 0.02). Mean disease duration at surgery decreased by 5.2 years (p < 0.001). Overall seizure freedom (Engel class 1) increased from 66.7% to 70.9% (adjusted p = 0.04), despite an increase in complex surgeries (extratemporal and/or MRI negative). Surgeries performed during the later period were 1.34 times (adjusted odds ratio; 95% confidence interval 1.02-1.77) more likely to yield a favorable outcome (Engel class I) than earlier surgeries, and improvement was more marked in extratemporal and MRI-negative temporal epilepsy. The rate of persistent neurologic complications remained stable (4.6%-5.3%, p = 0.7). Conclusion Improvements in European epilepsy surgery over time are modest but significant, including higher surgical volume, shorter disease duration, and improved postsurgical seizure outcomes. Early referral for evaluation is required to continue on this encouraging trend.

Citovat

BAUD, M.O., T. PERNEGER, A. RACZ, M.C. PENSEL, C. ELGER, B. RYDENHAG, K. MALMGREN, J.H. CROSS, G. MCKENNA, M. TISDALL, H.J. LAMBERINK, S. RHEIMS, P. RYVLIN, J. ISNARD, F. MAUGUIERE, A. ARZIMANOGLOU, S. AKKOL, K. DENIZ, C. OZKARA, M. LOSSIUS, Ivan REKTOR, R. KALVIAINEN, L.M. VANHATALO, P. DIMOVA, K. MINKIN, A.M. STAACK, B.J. STEINHOFF, A. KALINA, P. KRSEK, P. MARUSIC, Z. JORDAN, D. FABO, E. CARRETTE, P. BOON, S. ROCKA, R. MAMENISKIENE, S. VULLIEMOZ, F. PITTAU, K.P.J. BRAUN a M. SEECK. European trends in epilepsy surgery. Neurology. Philadelphia: LIPPINCOTT WILLIAMS & WILKINS, 2018, roč. 91, č. 2, s. "E96"-"E106", 11 s. ISSN 0028-3878. Dostupné z: https://dx.doi.org/10.1212/WNL.0000000000005776.

@article{1507737,
   author = {Baud, M.O. and Perneger, T. and Racz, A. and Pensel, M.C. and Elger, C. and Rydenhag, B. and Malmgren, K. and Cross, J.H. and McKenna, G. and Tisdall, M. and Lamberink, H.J. and Rheims, S. and Ryvlin, P. and Isnard, J. and Mauguiere, F. and Arzimanoglou, A. and Akkol, S. and Deniz, K. and Ozkara, C. and Lossius, M. and Rektor, Ivan and Kalviainen, R. and Vanhatalo, L.M. and Dimova, P. and Minkin, K. and Staack, A.M. and Steinhoff, B.J. and Kalina, A. and Krsek, P. and Marusic, P. and Jordan, Z. and Fabo, D. and Carrette, E. and Boon, P. and Rocka, S. and Mameniskiene, R. and Vulliemoz, S. and Pittau, F. and Braun, K.P.J. and Seeck, M.},
   article_location = {Philadelphia},
   article_number = {2},
   doi = {http://dx.doi.org/10.1212/WNL.0000000000005776},
   keywords = {TEMPORAL-LOBE EPILEPSY; UNITED-STATES; SURGICAL-TREATMENT; OUTCOMES; COMPLICATIONS; ASSOCIATION; RESECTIONS; CENTERS; ADULT; TRIAL},
   language = {eng},
   issn = {0028-3878},
   journal = {Neurology},
   title = {European trends in epilepsy surgery},
   url = {http://dx.doi.org/10.1212/WNL.0000000000005776},
   volume = {91},
   year = {2018}
}

TY  - JOUR
ID  - 1507737
AU  - Baud, M.O. - Perneger, T. - Racz, A. - Pensel, M.C. - Elger, C. - Rydenhag, B. - Malmgren, K. - Cross, J.H. - McKenna, G. - Tisdall, M. - Lamberink, H.J. - Rheims, S. - Ryvlin, P. - Isnard, J. - Mauguiere, F. - Arzimanoglou, A. - Akkol, S. - Deniz, K. - Ozkara, C. - Lossius, M. - Rektor, Ivan - Kalviainen, R. - Vanhatalo, L.M. - Dimova, P. - Minkin, K. - Staack, A.M. - Steinhoff, B.J. - Kalina, A. - Krsek, P. - Marusic, P. - Jordan, Z. - Fabo, D. - Carrette, E. - Boon, P. - Rocka, S. - Mameniskiene, R. - Vulliemoz, S. - Pittau, F. - Braun, K.P.J. - Seeck, M.
PY  - 2018
TI  - European trends in epilepsy surgery
JF  - Neurology
VL  - 91
IS  - 2
SP  - "E96"-"E106"
EP  - "E96"-"E106"
PB  - LIPPINCOTT WILLIAMS & WILKINS
SN  - 00283878
KW  - TEMPORAL-LOBE EPILEPSY
KW  - UNITED-STATES
KW  - SURGICAL-TREATMENT
KW  - OUTCOMES
KW  - COMPLICATIONS
KW  - ASSOCIATION
KW  - RESECTIONS
KW  - CENTERS
KW  - ADULT
KW  - TRIAL
UR  - http://dx.doi.org/10.1212/WNL.0000000000005776
N2  - Objective Resective surgery is effective in treating drug-resistant focal epilepsy, but it remains unclear whether improved diagnostics influence postsurgical outcomes. Here, we compared practice and outcomes over 2 periods 15 years apart. Methods Sixteen European centers retrospectively identified 2 cohorts of children and adults who underwent epilepsy surgery in the period of 1997 to 1998 (n = 562) or 2012 to 2013 (n = 736). Data collected included patient (sex, age) and disease (duration, localization and diagnosis) characteristics, type of surgery, histopathology, Engel postsurgical outcome, and complications, as well as imaging and electrophysiologic tests performed for each case. Postsurgical outcome predictors were included in a multivariate logistic regression to assess the strength of date of surgery as an independent predictor. Results Over time, the number of operated cases per center increased from a median of 31 to 50 per 2-year period (p = 0.02). Mean disease duration at surgery decreased by 5.2 years (p < 0.001). Overall seizure freedom (Engel class 1) increased from 66.7% to 70.9% (adjusted p = 0.04), despite an increase in complex surgeries (extratemporal and/or MRI negative). Surgeries performed during the later period were 1.34 times (adjusted odds ratio; 95% confidence interval 1.02-1.77) more likely to yield a favorable outcome (Engel class I) than earlier surgeries, and improvement was more marked in extratemporal and MRI-negative temporal epilepsy. The rate of persistent neurologic complications remained stable (4.6%-5.3%, p = 0.7). Conclusion Improvements in European epilepsy surgery over time are modest but significant, including higher surgical volume, shorter disease duration, and improved postsurgical seizure outcomes. Early referral for evaluation is required to continue on this encouraging trend.
ER  -

BAUD, M.O., T. PERNEGER, A. RACZ, M.C. PENSEL, C. ELGER, B. RYDENHAG, K. MALMGREN, J.H. CROSS, G. MCKENNA, M. TISDALL, H.J. LAMBERINK, S. RHEIMS, P. RYVLIN, J. ISNARD, F. MAUGUIERE, A. ARZIMANOGLOU, S. AKKOL, K. DENIZ, C. OZKARA, M. LOSSIUS, Ivan REKTOR, R. KALVIAINEN, L.M. VANHATALO, P. DIMOVA, K. MINKIN, A.M. STAACK, B.J. STEINHOFF, A. KALINA, P. KRSEK, P. MARUSIC, Z. JORDAN, D. FABO, E. CARRETTE, P. BOON, S. ROCKA, R. MAMENISKIENE, S. VULLIEMOZ, F. PITTAU, K.P.J. BRAUN a M. SEECK. European trends in epilepsy surgery. \textit{Neurology}. Philadelphia: LIPPINCOTT WILLIAMS \&{} WILKINS, 2018, roč.~91, č.~2, s.~''E96''-''E106'', 11 s. ISSN~0028-3878. Dostupné z: https://dx.doi.org/10.1212/WNL.0000000000005776.

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