Penetration, distribution and brain toxicity of titanium nanoparticles in rodents' body: a review.

ZEMAN, Tomáš, El -Wui LOH, Daniel ČIERNY and Omar ŠERÝ. Penetration, distribution and brain toxicity of titanium nanoparticles in rodents' body: a review. IET Nanobiotechnology. England: The Institution of Engineering and Technology, 2018, vol. 12, No 6, p. 695-700. ISSN 1751-8741. Available from: https://dx.doi.org/10.1049/iet-nbt.2017.0109.

Basic information

• Original name: Penetration, distribution and brain toxicity of titanium nanoparticles in rodents' body: a review.
• Authors: ZEMAN, Tomáš (203 Czech Republic, belonging to the institution), El -Wui LOH (458 Malaysia), Daniel ČIERNY (703 Slovakia, guarantor) and Omar ŠERÝ (203 Czech Republic, belonging to the institution).
• Edition: IET Nanobiotechnology, England, The Institution of Engineering and Technology, 2018, 1751-8741.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30108 Toxicology
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 1.925
• RIV identification code: RIV/00216224:14310/18:00106672
• Organization unit: Faculty of Science
• Doi: http://dx.doi.org/10.1049/iet-nbt.2017.0109
• UT WoS: 000441513100001
• Keywords (in Czech): nanočástice
• Keywords in English: nanoparticles

Abstract

Titanium dioxide (TiO2) has been vastly used commercially, especially as white pigment in paints, colorants, plastics, coatings, cosmetics. There are three common exposure routes for TiO2: (i) inhalation exposure, (ii) exposure via gastrointestinal tract, (iii) dermal exposure. Inhalation and gastrointestinal exposure appear to be the most probable ways of exposure, although nanoparticle (NP) penetration is limited. However, the penetration rate may increase substantially when the tissue is impaired. When TiO2 NPs migrate into the circulatory system, they can be distributed into all tissues including brain. In brain, TiO2 lead to oxidative stress mediated by the microglia phagocytic cells which respond to TiO2 NPs by the production and release of superoxide radicals that convert to multiple reactive oxygen species (ROS). The ROS production may also cause the damage of blood-brain barrier which then becomes more permeable for NPs. Moreover, several studies have showed neuron degradation and the impairment of spatial recognition memory and learning abilities in laboratory rodent exposed to TiO2 NPs.