Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is
Related to Clinicopathological Features of Gastric Cancer in a
Central European Population

J 2018

Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population

OBERMANNOVA, R., Martina LOJOVÁ, Petra VYCHYTILOVÁ, P. GRELL, W.C. CHO et. al.

Základní údaje

Originální název

Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population

Autoři

OBERMANNOVA, R. (203 Česká republika), Martina LOJOVÁ (203 Česká republika, domácí), Petra VYCHYTILOVÁ (203 Česká republika, domácí), P. GRELL (203 Česká republika), W.C. CHO (344 Hongkong), M. SACHLOVA (203 Česká republika), M. SVOBODA (203 Česká republika), R. VYZULA (203 Česká republika) a Ondřej SLABÝ (203 Česká republika, garant, domácí)

Vydání

Anticancer Research, Athens, International Institute of Anticancer Research, 2018, 0250-7005

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Řecko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.935

Kód RIV

RIV/00216224:14740/18:00106974

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.21873/anticanres.12651

UT WoS

000449934200066

Klíčová slova anglicky

Gastric cancer; microRNA; diagnosis; prognosis

Štítky

Excelence Science, MU, RIV, rivok, user

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 3. 2019 09:41, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Background/Aim: In Western countries, most patients with gastric cancer (GC) present in advanced stages. Therefore, there is imminent clinical need for novel diagnostic and prognostic biomarkers. Deregulation of microRNAs has been reported as a frequent event in GC development in a number of studies. Our study validated the potential of microRNAs to serve as diagnostic and prognostic biomarkers in patients with GC from the Central European population. Materials and Methods: Using quantitative real-time polymerase chain reaction, expression levels of six microRNAs (miR-10b, -21, -93, -107, - 143 , and -145) were examined in 67 tumor tissues and 67 paired adjacent gastric tissues, and correlated with clinicopathological features of GC patients. Results: Expression levels of miR-10b, miR-21, miR-93 , and miR-107 were significantly higher in GC samples compared to non-tumor tissue. Furthermore, the expression levels of miR-10b, miR-143, and miR-145 positively correlated with advanced stages, and increased expression of miR-10b, miR-21 and miR-145 was significantly associated with worse prognosis of gastric cancer patients. Conclusion: Our results indicate that selected tissue microRNAs have the potential to serve as relevant diagnostic and prognostic biomarkers of GC in a central European population.

Návaznosti

NV17-29389A, projekt VaV

Název: Sekvenční FDG-PET a miRNA jako biomarker změny strategie předoperační léčby u lokálně pokročilého karcinomu žaludku a gastroesofageální junkce

Citovat

OBERMANNOVA, R., Martina LOJOVÁ, Petra VYCHYTILOVÁ, P. GRELL, W.C. CHO, M. SACHLOVA, M. SVOBODA, R. VYZULA a Ondřej SLABÝ. Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population. Anticancer Research. Athens: International Institute of Anticancer Research, 2018, roč. 38, č. 6, s. 3719-3724. ISSN 0250-7005. Dostupné z: https://dx.doi.org/10.21873/anticanres.12651.

@article{1508717,
   author = {Obermannova, R. and Lojová, Martina and Vychytilová, Petra and Grell, P. and Cho, W.C. and Sachlova, M. and Svoboda, M. and Vyzula, R. and Slabý, Ondřej},
   article_location = {Athens},
   article_number = {6},
   doi = {http://dx.doi.org/10.21873/anticanres.12651},
   keywords = {Gastric cancer; microRNA; diagnosis; prognosis},
   language = {eng},
   issn = {0250-7005},
   journal = {Anticancer Research},
   title = {Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population},
   volume = {38},
   year = {2018}
}

TY  - JOUR
ID  - 1508717
AU  - Obermannova, R. - Lojová, Martina - Vychytilová, Petra - Grell, P. - Cho, W.C. - Sachlova, M. - Svoboda, M. - Vyzula, R. - Slabý, Ondřej
PY  - 2018
TI  - Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population
JF  - Anticancer Research
VL  - 38
IS  - 6
SP  - 3719-3724
EP  - 3719-3724
PB  - International Institute of Anticancer Research
SN  - 02507005
KW  - Gastric cancer
KW  - microRNA
KW  - diagnosis
KW  - prognosis
N2  - Background/Aim: In Western countries, most patients with gastric cancer (GC) present in advanced stages. Therefore, there is imminent clinical need for novel diagnostic and prognostic biomarkers. Deregulation of microRNAs has been reported as a frequent event in GC development in a number of studies. Our study validated the potential of microRNAs to serve as diagnostic and prognostic biomarkers in patients with GC from the Central European population. Materials and Methods: Using quantitative real-time polymerase chain reaction, expression levels of six microRNAs (miR-10b, -21, -93, -107, - 143 , and -145) were examined in 67 tumor tissues and 67 paired adjacent gastric tissues, and correlated with clinicopathological features of GC patients. Results: Expression levels of miR-10b, miR-21, miR-93 , and miR-107 were significantly higher in GC samples compared to non-tumor tissue. Furthermore, the expression levels of miR-10b, miR-143, and miR-145 positively correlated with advanced stages, and increased expression of miR-10b, miR-21 and miR-145 was significantly associated with worse prognosis of gastric cancer patients. Conclusion: Our results indicate that selected tissue microRNAs have the potential to serve as relevant diagnostic and prognostic biomarkers of GC in a central European population.
ER  -

OBERMANNOVA, R., Martina LOJOVÁ, Petra VYCHYTILOVÁ, P. GRELL, W.C. CHO, M. SACHLOVA, M. SVOBODA, R. VYZULA a Ondřej SLABÝ. Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population. \textit{Anticancer Research}. Athens: International Institute of Anticancer Research, 2018, roč.~38, č.~6, s.~3719-3724. ISSN~0250-7005. Dostupné z: https://dx.doi.org/10.21873/anticanres.12651.

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