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@article{1509096,
author = {Kubínová, Renata and Gazdová, Markéta and Hanáková, Zuzana and Jurkaninova, S. and Dall, Acqua S and Cvačka, Josef and Humpa, Otakar},
article_location = {AMSTERDAM},
article_number = {0254-6299},
doi = {http://dx.doi.org/10.1016/j.sajb.2018.08.023},
keywords = {Plectranthus scutellarioides; Diterpene glucoside; Flavonoids; Hyaluronidase; ORAC values; Acetylcholinesterase and butyrylcholinesterase; inhibitory activities},
language = {eng},
issn = {0254-6299},
journal = {SOUTH AFRICAN JOURNAL OF BOTANY},
title = {New diterpenoid glucoside and flavonoids from Plectranthus scutellarioides (L.) R. Br.},
url = {https://www.sciencedirect.com/science/article/pii/S0254629918308366},
volume = {120},
year = {2019}
}
TY - JOUR
ID - 1509096
AU - Kubínová, Renata - Gazdová, Markéta - Hanáková, Zuzana - Jurkaninova, S. - Dall, Acqua S - Cvačka, Josef - Humpa, Otakar
PY - 2019
TI - New diterpenoid glucoside and flavonoids from Plectranthus scutellarioides (L.) R. Br.
JF - SOUTH AFRICAN JOURNAL OF BOTANY
VL - 120
IS - 0254-6299
SP - 286-290
EP - 286-290
PB - ELSEVIER SCIENCE BV
SN - 02546299
KW - Plectranthus scutellarioides
KW - Diterpene glucoside
KW - Flavonoids
KW - Hyaluronidase
KW - ORAC values
KW - Acetylcholinesterase and butyrylcholinesterase
KW - inhibitory activities
UR - https://www.sciencedirect.com/science/article/pii/S0254629918308366
L2 - https://www.sciencedirect.com/science/article/pii/S0254629918308366
N2 - Three new compounds, diterpenoid glucoside (13S, 15S)-6 beta, 7 alpha, 12 alpha-trihydroxy-13 beta, 16-cyclo-8-abietene11,14- dione 7-O-beta-D-glucoside 1, flavonoids apigenin 7-O-(3''-O-acetyl)-beta-D-glucuronide 2 and apigenin 5-O( 3''-O-acetyl)-beta-D-glucuronide 3, together with known compounds caffeic acid 4, luteolin 5-O-beta-D-glucoside 5 and rosmarinic acid 6 were isolated from the aerial parts of Plectranthus scutellarioides (L.) R. Br. The structures of the new compounds were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-and 2D-NMR. Compound 1 inhibited hyaluronidase by 25% at the concentration of 200 mu M, compounds 2 and 3 showed inhibitory activity on butyrylcholinesterase better than standard galanthamine at the concentration of 100 mu M, and compound 6 is a potent antioxidant with an ORAC value of 2.15 +/- 0.12. (c) 2018 SAAB. Published by Elsevier B. V. All rights reserved.
ER -
KUBÍNOVÁ, Renata, Markéta GAZDOVÁ, Zuzana HANÁKOVÁ, S. JURKANINOVA, Acqua S DALL, Josef CVAČKA a Otakar HUMPA. New diterpenoid glucoside and flavonoids from Plectranthus scutellarioides (L.) R. Br. \textit{SOUTH AFRICAN JOURNAL OF BOTANY}. AMSTERDAM: ELSEVIER SCIENCE BV, 2019, roč.~120, 0254-6299, s.~286-290. ISSN~0254-6299. Dostupné z: https://dx.doi.org/10.1016/j.sajb.2018.08.023.
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