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@article{1509199,
author = {Paleček, Jan},
article_location = {BASEL},
article_number = {1},
doi = {http://dx.doi.org/10.3390/genes10010007},
keywords = {SMC complexes; SMC5/6; chromatin structure; loop extrusion; stalled replication fork; replication fork regression; collapsed replication fork; homologous recombination},
language = {eng},
issn = {2073-4425},
journal = {GENES},
title = {SMC5/6: Multifunctional Player in Replication},
url = {https://www.mdpi.com/2073-4425/10/1/7},
volume = {10},
year = {2019}
}
TY - JOUR
ID - 1509199
AU - Paleček, Jan
PY - 2019
TI - SMC5/6: Multifunctional Player in Replication
JF - GENES
VL - 10
IS - 1
SP - 1-14
EP - 1-14
PB - MDPI AG
SN - 20734425
KW - SMC complexes
KW - SMC5/6
KW - chromatin structure
KW - loop extrusion
KW - stalled replication fork
KW - replication fork regression
KW - collapsed replication fork
KW - homologous recombination
UR - https://www.mdpi.com/2073-4425/10/1/7
L2 - https://www.mdpi.com/2073-4425/10/1/7
N2 - The genome replication process is challenged at many levels. Replication must proceed through different problematic sites and obstacles, some of which can pause or even reverse the replication fork (RF). In addition, replication of DNA within chromosomes must deal with their topological constraints and spatial organization. One of the most important factors organizing DNA into higher-order structures are Structural Maintenance of Chromosome (SMC) complexes. In prokaryotes, SMC complexes ensure proper chromosomal partitioning during replication. In eukaryotes, cohesin and SMC5/6 complexes assist in replication. Interestingly, the SMC5/6 complexes seem to be involved in replication in many ways. They stabilize stalled RFs, restrain RF regression, participate in the restart of collapsed RFs, and buffer topological constraints during RF progression. In this (mini) review, I present an overview of these replication-related functions of SMC5/6.
ER -
PALEČEK, Jan. SMC5/6: Multifunctional Player in Replication. \textit{GENES}. BASEL: MDPI AG, 2019, roč.~10, č.~1, s.~1-14. ISSN~2073-4425. Dostupné z: https://dx.doi.org/10.3390/genes10010007.
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