SMC5/6: Multifunctional Player in Replication

J 2019

SMC5/6: Multifunctional Player in Replication

PALEČEK, Jan

Základní údaje

Originální název

SMC5/6: Multifunctional Player in Replication

Název česky

SMC5/6: Multifunkční hráč v replikaci

Autoři

PALEČEK, Jan (203 Česká republika, garant, domácí)

Vydání

GENES, BASEL, MDPI AG, 2019, 2073-4425

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.759

Kód RIV

RIV/00216224:14310/19:00107323

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.3390/genes10010007

UT WoS

000459743800007

Klíčová slova anglicky

SMC complexes; SMC5/6; chromatin structure; loop extrusion; stalled replication fork; replication fork regression; collapsed replication fork; homologous recombination

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 3. 2020 19:05, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

The genome replication process is challenged at many levels. Replication must proceed through different problematic sites and obstacles, some of which can pause or even reverse the replication fork (RF). In addition, replication of DNA within chromosomes must deal with their topological constraints and spatial organization. One of the most important factors organizing DNA into higher-order structures are Structural Maintenance of Chromosome (SMC) complexes. In prokaryotes, SMC complexes ensure proper chromosomal partitioning during replication. In eukaryotes, cohesin and SMC5/6 complexes assist in replication. Interestingly, the SMC5/6 complexes seem to be involved in replication in many ways. They stabilize stalled RFs, restrain RF regression, participate in the restart of collapsed RFs, and buffer topological constraints during RF progression. In this (mini) review, I present an overview of these replication-related functions of SMC5/6.

Návaznosti

GA18-02067S, projekt VaV

Název: Úloha Nse1/Nse3/Nse4, E3-ubikvitin ligásy, ve stabilitě genomu

Investor: Grantová agentura ČR, Úloha Nse1/Nse3/Nse4, E3-ubikvitin ligásy, ve stabilitě genomu

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

PALEČEK, Jan. SMC5/6: Multifunctional Player in Replication. GENES. BASEL: MDPI AG, 2019, roč. 10, č. 1, s. 1-14. ISSN 2073-4425. Dostupné z: https://dx.doi.org/10.3390/genes10010007.

@article{1509199,
   author = {Paleček, Jan},
   article_location = {BASEL},
   article_number = {1},
   doi = {http://dx.doi.org/10.3390/genes10010007},
   keywords = {SMC complexes; SMC5/6; chromatin structure; loop extrusion; stalled replication fork; replication fork regression; collapsed replication fork; homologous recombination},
   language = {eng},
   issn = {2073-4425},
   journal = {GENES},
   title = {SMC5/6: Multifunctional Player in Replication},
   url = {https://www.mdpi.com/2073-4425/10/1/7},
   volume = {10},
   year = {2019}
}

TY  - JOUR
ID  - 1509199
AU  - Paleček, Jan
PY  - 2019
TI  - SMC5/6: Multifunctional Player in Replication
JF  - GENES
VL  - 10
IS  - 1
SP  - 1-14
EP  - 1-14
PB  - MDPI AG
SN  - 20734425
KW  - SMC complexes
KW  - SMC5/6
KW  - chromatin structure
KW  - loop extrusion
KW  - stalled replication fork
KW  - replication fork regression
KW  - collapsed replication fork
KW  - homologous recombination
UR  - https://www.mdpi.com/2073-4425/10/1/7
L2  - https://www.mdpi.com/2073-4425/10/1/7
N2  - The genome replication process is challenged at many levels. Replication must proceed through different problematic sites and obstacles, some of which can pause or even reverse the replication fork (RF). In addition, replication of DNA within chromosomes must deal with their topological constraints and spatial organization. One of the most important factors organizing DNA into higher-order structures are Structural Maintenance of Chromosome (SMC) complexes. In prokaryotes, SMC complexes ensure proper chromosomal partitioning during replication. In eukaryotes, cohesin and SMC5/6 complexes assist in replication. Interestingly, the SMC5/6 complexes seem to be involved in replication in many ways. They stabilize stalled RFs, restrain RF regression, participate in the restart of collapsed RFs, and buffer topological constraints during RF progression. In this (mini) review, I present an overview of these replication-related functions of SMC5/6.
ER  -

PALEČEK, Jan. SMC5/6: Multifunctional Player in Replication. \textit{GENES}. BASEL: MDPI AG, 2019, roč.~10, č.~1, s.~1-14. ISSN~2073-4425. Dostupné z: https://dx.doi.org/10.3390/genes10010007.

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