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@article{1514537,
author = {Fišarová, Lenka and Pantůček, Roman and Botka, Tibor and Doškař, Jiří},
article_location = {Amsterdam},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.resmic.2018.11.004},
keywords = {Coagulase-negative staphylococci; Resistance plasmids; Antibiotics; Interspecies horizontal gene transfer; Electroporation},
language = {eng},
issn = {0923-2508},
journal = {Research in Microbiology},
title = {Variability of resistance plasmids in coagulase-negative staphylococci and their importance as a reservoir of antimicrobial resistance},
url = {https://www.sciencedirect.com/science/article/pii/S0923250818301608},
volume = {170},
year = {2019}
}
TY - JOUR
ID - 1514537
AU - Fišarová, Lenka - Pantůček, Roman - Botka, Tibor - Doškař, Jiří
PY - 2019
TI - Variability of resistance plasmids in coagulase-negative staphylococci and their importance as a reservoir of antimicrobial resistance
JF - Research in Microbiology
VL - 170
IS - 2
SP - 105-111
EP - 105-111
PB - Elsevier Science
SN - 09232508
KW - Coagulase-negative staphylococci
KW - Resistance plasmids
KW - Antibiotics
KW - Interspecies horizontal gene transfer
KW - Electroporation
UR - https://www.sciencedirect.com/science/article/pii/S0923250818301608
L2 - https://www.sciencedirect.com/science/article/pii/S0923250818301608
N2 - Coagulase-negative staphylococci (CoNS) are an important cause of human and animal diseases. Treatment of these diseases is complicated by their common antimicrobial resistance, caused by overuse of antibiotics in hospital and veterinary environment. Therefore, they are assumed to serve as a reservoir of resistance genes often located on plasmids. In this study, we analyzed plasmid content in 62 strains belonging to 10 CoNS species of human and veterinary origin. In 48 (77%) strains analyzed, 107 different plasmids were detected, and only some of them showed similarities with plasmids found previously. In total, seven different antimicrobial-resistance genes carried by plasmids were identified. Five of the CoNS staphylococci carried plasmids identical with either those of other CoNS species tested, or a well characterized Staphylococcus aureus strain COL, suggesting plasmid dissemination through horizontal transfer. To demonstrate the possibility of horizontal transfer, we performed electroporation of four resistance plasmids among Staphylococcus epidermidis, Staphylococcus petrasii, and coagulase-positive S. aureus strains. Plasmids were transferred unchanged, were stably maintained in recipient strains, and expressed resistance genes. Our work demonstrates a great variability of plasmids in human and veterinary staphylococcal strains and their ability to maintain and express resistance plasmids from other staphylococcal species.
ER -
FIŠAROVÁ, Lenka, Roman PANTŮČEK, Tibor BOTKA a Jiří DOŠKAŘ. Variability of resistance plasmids in coagulase-negative staphylococci and their importance as a reservoir of antimicrobial resistance. \textit{Research in Microbiology}. Amsterdam: Elsevier Science, 2019, roč.~170, č.~2, s.~105-111. ISSN~0923-2508. Dostupné z: https://dx.doi.org/10.1016/j.resmic.2018.11.004.
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