Chemokine Receptor 2 (CXCR2) Gene Variants and Their
Association with Periodontal Bacteria in Patients with Chronic
Periodontitis

J 2019

Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis

KAVŘÍKOVÁ, Denisa, Petra BOŘILOVÁ LINHARTOVÁ, Světlana LUČANOVÁ, Hana POSKEROVÁ, Antonín FASSMANN et. al.

Základní údaje

Originální název

Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis

Autoři

KAVŘÍKOVÁ, Denisa (203 Česká republika, domácí), Petra BOŘILOVÁ LINHARTOVÁ (203 Česká republika, domácí), Světlana LUČANOVÁ (203 Česká republika, domácí), Hana POSKEROVÁ (203 Česká republika, domácí), Antonín FASSMANN (203 Česká republika, domácí) a Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika, domácí)

Vydání

MEDIATORS OF INFLAMMATION, London, HINDAWI LTD, 2019, 0962-9351

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30208 Dentistry, oral surgery and medicine

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.758

Kód RIV

RIV/00216224:14110/19:00107344

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1155/2019/2061868

UT WoS

000459076200001

Klíčová slova anglicky

Periodontitis

Štítky

14110130, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 4. 2019 10:24, Soňa Böhmová

Anotace

V originále

Periodontitis, an inflammatory disease caused by subgingival Gram-negative (G-) bacteria, is linked with loss of the connective tissue and destruction of the alveolar bone. In the regulation of inflammatory response, chemokine receptor 2 (CXCR2), a specific receptor for interleukin-8 and neutrophil chemoattractant, plays an important role. The first aim of this study was to investigate the CXCR2 gene variability in chronic periodontitis (CP) patients and healthy nonperiodontitis controls in the Czech population. The second aim was to find a relation between CXCR2 gene variants and the presence of periodontal bacteria. A total of 500 unrelated subjects participated in this case-control study. 329 CP patients and 171 healthy nonperiodontitis controls were analyzed using polymerase chain reaction techniques for three single-nucleotide polymorphisms (SNPs): +785C/T (rs2230054), +1208T/C (rs1126579), and +1440A/G (rs1126580). A DNA microarray detection kit was used for the investigation of the subgingival bacterial colonization, in a subgroup of CP subjects (N=162). No significant differences in allele, genotype, haplotype, or haplogenotype frequencies of CXCR2 gene variants between patients with CP and healthy controls (P>0.05) were determined. Nevertheless, Aggregatibacter actinomycetemcomitans was detected more frequently in men positive for the C allele of the CXCR2 +785C/T polymorphism (61.8% vs. 41.1%, P<0.05; OR=2.31, 95% CI=1.03-5.20) and for the T allele of the CXCR2 +1208C/T variant (61.8% vs. 38.9%, P<0.05; OR=2.54, 95% CI=1.13-5.71). In contrast, no statistically significant associations of CXCR2 variants with seven selected periodontal bacteria were found in women. Although none of the investigated SNPs in the CXCR2 gene was associated with CP, the CXCR2 gene variants can be associated with subgingival colonization of G- bacteria in men with CP in the Czech population.

Návaznosti

GB14-37368G, projekt VaV

Název: Centrum orofaciálního vývoje a regenerace

Investor: Grantová agentura ČR, Centrum orofaciálního vývoje a regenerace

MUNI/A/1008/2017, interní kód MU

Název: Etiopatogenetické aspekty, diagnostika a léčba vybraných onemocnění dutiny ústní

Investor: Masarykova univerzita, Etiopatogenetické aspekty, diagnostika a léčba vybraných onemocnění dutiny ústní, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

ROZV/25/LF/2017, interní kód MU

Název: LF - Příspěvek na IP 2017

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, LF - Příspěvek na IP 2017, Interní rozvojové projekty

Citovat

KAVŘÍKOVÁ, Denisa, Petra BOŘILOVÁ LINHARTOVÁ, Světlana LUČANOVÁ, Hana POSKEROVÁ, Antonín FASSMANN a Lydie IZAKOVIČOVÁ HOLLÁ. Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis. MEDIATORS OF INFLAMMATION. London: HINDAWI LTD, 2019, roč. 2019, č. 2061868, s. 1-8. ISSN 0962-9351. Dostupné z: https://dx.doi.org/10.1155/2019/2061868.

@article{1517516,
   author = {Kavříková, Denisa and Bořilová Linhartová, Petra and Lučanová, Světlana and Poskerová, Hana and Fassmann, Antonín and Izakovičová Hollá, Lydie},
   article_location = {London},
   article_number = {2061868},
   doi = {http://dx.doi.org/10.1155/2019/2061868},
   keywords = {Periodontitis},
   language = {eng},
   issn = {0962-9351},
   journal = {MEDIATORS OF INFLAMMATION},
   title = {Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis},
   url = {http://dx.doi.org/10.1155/2019/2061868},
   volume = {2019},
   year = {2019}
}

TY  - JOUR
ID  - 1517516
AU  - Kavříková, Denisa - Bořilová Linhartová, Petra - Lučanová, Světlana - Poskerová, Hana - Fassmann, Antonín - Izakovičová Hollá, Lydie
PY  - 2019
TI  - Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis
JF  - MEDIATORS OF INFLAMMATION
VL  - 2019
IS  - 2061868
SP  - 1-8
EP  - 1-8
PB  - HINDAWI LTD
SN  - 09629351
KW  - Periodontitis
UR  - http://dx.doi.org/10.1155/2019/2061868
L2  - http://dx.doi.org/10.1155/2019/2061868
N2  - Periodontitis, an inflammatory disease caused by subgingival Gram-negative (G-) bacteria, is linked with loss of the connective tissue and destruction of the alveolar bone. In the regulation of inflammatory response, chemokine receptor 2 (CXCR2), a specific receptor for interleukin-8 and neutrophil chemoattractant, plays an important role. The first aim of this study was to investigate the CXCR2 gene variability in chronic periodontitis (CP) patients and healthy nonperiodontitis controls in the Czech population. The second aim was to find a relation between CXCR2 gene variants and the presence of periodontal bacteria. A total of 500 unrelated subjects participated in this case-control study. 329 CP patients and 171 healthy nonperiodontitis controls were analyzed using polymerase chain reaction techniques for three single-nucleotide polymorphisms (SNPs): +785C/T (rs2230054), +1208T/C (rs1126579), and +1440A/G (rs1126580). A DNA microarray detection kit was used for the investigation of the subgingival bacterial colonization, in a subgroup of CP subjects (N=162). No significant differences in allele, genotype, haplotype, or haplogenotype frequencies of CXCR2 gene variants between patients with CP and healthy controls (P>0.05) were determined. Nevertheless, Aggregatibacter actinomycetemcomitans was detected more frequently in men positive for the C allele of the CXCR2 +785C/T polymorphism (61.8% vs. 41.1%, P<0.05; OR=2.31, 95% CI=1.03-5.20) and for the T allele of the CXCR2 +1208C/T variant (61.8% vs. 38.9%, P<0.05; OR=2.54, 95% CI=1.13-5.71). In contrast, no statistically significant associations of CXCR2 variants with seven selected periodontal bacteria were found in women. Although none of the investigated SNPs in the CXCR2 gene was associated with CP, the CXCR2 gene variants can be associated with subgingival colonization of G- bacteria in men with CP in the Czech population.
ER  -

KAVŘÍKOVÁ, Denisa, Petra BOŘILOVÁ LINHARTOVÁ, Světlana LUČANOVÁ, Hana POSKEROVÁ, Antonín FASSMANN a Lydie IZAKOVIČOVÁ HOLLÁ. Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis. \textit{MEDIATORS OF INFLAMMATION}. London: HINDAWI LTD, 2019, roč.~2019, č.~2061868, s.~1-8. ISSN~0962-9351. Dostupné z: https://dx.doi.org/10.1155/2019/2061868.

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