Intervertebral disc penetration by antibiotics used
prophylactically in spinal surgery: implications for the
current standards and treatment of disc infections

J 2019

Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections

CAPOOR, Manu, Jan LOCHMAN, Andrew MCDOWELL, Jonathan E. SCHMITZ, Martin SOLANSKÝ et. al.

Základní údaje

Originální název

Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections

Autoři

CAPOOR, Manu (840 Spojené státy, domácí), Jan LOCHMAN (203 Česká republika, domácí), Andrew MCDOWELL (826 Velká Británie a Severní Irsko), Jonathan E. SCHMITZ (840 Spojené státy), Martin SOLANSKÝ (203 Česká republika, domácí), Martina ZAPLETALOVÁ (203 Česká republika, domácí), Todd F. ALAMIN (840 Spojené státy), Michael F. COSCIA (840 Spojené státy), Steven R. GARFIN (840 Spojené státy), Radim JANČÁLEK (203 Česká republika, domácí), Filip RŮŽIČKA (203 Česká republika, domácí), Nick A. SHAMIE (840 Spojené státy), Martin SMRČKA (203 Česká republika, domácí), Jeffrey C. WANG (840 Spojené státy), Christof BIRKENMAIER (276 Německo) a Ondřej SLABÝ (203 Česká republika, garant, domácí)

Vydání

European Spine Journal, NEW YORK, Springer, 2019, 0940-6719

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.458

Kód RIV

RIV/00216224:14740/19:00109487

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1007/s00586-018-5838-z

UT WoS

000463673200018

Klíčová slova anglicky

Propionibacterium acnes; Cutibacterium acnes; Degenerative disc disease; Biofilm; Cefazolin; Clindamycin; Vancomycin; Surgical prophylaxis

Štítky

14110113, 14110131, 14110224, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 3. 2020 16:50, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

PurposeThe presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate the pathology of degenerative disc disease. This hypothesis, therefore, raises the exciting possibility that antibiotics could play an important role in treating this debilitating condition. To date, however, little information about antibiotic penetration into the intervertebral disc is available. MethodsIntervertebral disc tissue obtained from 54 microdiscectomy patients given prophylactic cefazolin (n=25), clindamycin (n=17) or vancomycin (n=12) was assayed by high-performance liquid chromatography, with cefaclor as an internal standard, to determine the concentration of antibiotic penetrating into the disc tissue.ResultsIntervertebral disc tissues from patients receiving the positively charged antibiotic clindamycin contained a significantly greater percentage of the antibacterial dose than the tissue from patients receiving negatively charged cefazolin (P<0.0001) and vancomycin, which has a slight positive charge (P<0.0001).ConclusionPositively charged antibiotics appear more appropriate for future studies investigating potential options for the treatment of low-virulence disc infections. [GRAPHICS]

Návaznosti

MUNI/A/1189/2018, interní kód MU

Název: Původci nozokomiálních nákaz a možnosti jejich diagnostiky a terapie (Akronym: PNNMDT)

Investor: Masarykova univerzita, Původci nozokomiálních nákaz a možnosti jejich diagnostiky a terapie, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

CAPOOR, Manu, Jan LOCHMAN, Andrew MCDOWELL, Jonathan E. SCHMITZ, Martin SOLANSKÝ, Martina ZAPLETALOVÁ, Todd F. ALAMIN, Michael F. COSCIA, Steven R. GARFIN, Radim JANČÁLEK, Filip RŮŽIČKA, Nick A. SHAMIE, Martin SMRČKA, Jeffrey C. WANG, Christof BIRKENMAIER a Ondřej SLABÝ. Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections. European Spine Journal. NEW YORK: Springer, 2019, roč. 28, č. 4, s. 783-791. ISSN 0940-6719. Dostupné z: https://dx.doi.org/10.1007/s00586-018-5838-z.

@article{1522757,
   author = {Capoor, Manu and Lochman, Jan and McDowell, Andrew and Schmitz, Jonathan E. and Solanský, Martin and Zapletalová, Martina and Alamin, Todd F. and Coscia, Michael F. and Garfin, Steven R. and Jančálek, Radim and Růžička, Filip and Shamie, Nick A. and Smrčka, Martin and Wang, Jeffrey C. and Birkenmaier, Christof and Slabý, Ondřej},
   article_location = {NEW YORK},
   article_number = {4},
   doi = {http://dx.doi.org/10.1007/s00586-018-5838-z},
   keywords = {Propionibacterium acnes; Cutibacterium acnes; Degenerative disc disease; Biofilm; Cefazolin; Clindamycin; Vancomycin; Surgical prophylaxis},
   language = {eng},
   issn = {0940-6719},
   journal = {European Spine Journal},
   title = {Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections},
   url = {https://link.springer.com/content/pdf/10.1007/s00586-018-5838-z.pdf},
   volume = {28},
   year = {2019}
}

TY  - JOUR
ID  - 1522757
AU  - Capoor, Manu - Lochman, Jan - McDowell, Andrew - Schmitz, Jonathan E. - Solanský, Martin - Zapletalová, Martina - Alamin, Todd F. - Coscia, Michael F. - Garfin, Steven R. - Jančálek, Radim - Růžička, Filip - Shamie, Nick A. - Smrčka, Martin - Wang, Jeffrey C. - Birkenmaier, Christof - Slabý, Ondřej
PY  - 2019
TI  - Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections
JF  - European Spine Journal
VL  - 28
IS  - 4
SP  - 783-791
EP  - 783-791
PB  - Springer
SN  - 09406719
KW  - Propionibacterium acnes
KW  - Cutibacterium acnes
KW  - Degenerative disc disease
KW  - Biofilm
KW  - Cefazolin
KW  - Clindamycin
KW  - Vancomycin
KW  - Surgical prophylaxis
UR  - https://link.springer.com/content/pdf/10.1007/s00586-018-5838-z.pdf
L2  - https://link.springer.com/content/pdf/10.1007/s00586-018-5838-z.pdf
N2  - PurposeThe presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate the pathology of degenerative disc disease. This hypothesis, therefore, raises the exciting possibility that antibiotics could play an important role in treating this debilitating condition. To date, however, little information about antibiotic penetration into the intervertebral disc is available. MethodsIntervertebral disc tissue obtained from 54 microdiscectomy patients given prophylactic cefazolin (n=25), clindamycin (n=17) or vancomycin (n=12) was assayed by high-performance liquid chromatography, with cefaclor as an internal standard, to determine the concentration of antibiotic penetrating into the disc tissue.ResultsIntervertebral disc tissues from patients receiving the positively charged antibiotic clindamycin contained a significantly greater percentage of the antibacterial dose than the tissue from patients receiving negatively charged cefazolin (P<0.0001) and vancomycin, which has a slight positive charge (P<0.0001).ConclusionPositively charged antibiotics appear more appropriate for future studies investigating potential options for the treatment of low-virulence disc infections. [GRAPHICS]
ER  -

CAPOOR, Manu, Jan LOCHMAN, Andrew MCDOWELL, Jonathan E. SCHMITZ, Martin SOLANSKÝ, Martina ZAPLETALOVÁ, Todd F. ALAMIN, Michael F. COSCIA, Steven R. GARFIN, Radim JANČÁLEK, Filip RŮŽIČKA, Nick A. SHAMIE, Martin SMRČKA, Jeffrey C. WANG, Christof BIRKENMAIER a Ondřej SLABÝ. Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections. \textit{European Spine Journal}. NEW YORK: Springer, 2019, roč.~28, č.~4, s.~783-791. ISSN~0940-6719. Dostupné z: https://dx.doi.org/10.1007/s00586-018-5838-z.

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