CAPOOR, Manu, Jan LOCHMAN, Andrew MCDOWELL, Jonathan E. SCHMITZ, Martin SOLANSKÝ, Martina ZAPLETALOVÁ, Todd F. ALAMIN, Michael F. COSCIA, Steven R. GARFIN, Radim JANČÁLEK, Filip RŮŽIČKA, Nick A. SHAMIE, Martin SMRČKA, Jeffrey C. WANG, Christof BIRKENMAIER a Ondřej SLABÝ. Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections. European Spine Journal. NEW YORK: Springer, 2019, roč. 28, č. 4, s. 783-791. ISSN 0940-6719. Dostupné z: https://dx.doi.org/10.1007/s00586-018-5838-z. |
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@article{1522757, author = {Capoor, Manu and Lochman, Jan and McDowell, Andrew and Schmitz, Jonathan E. and Solanský, Martin and Zapletalová, Martina and Alamin, Todd F. and Coscia, Michael F. and Garfin, Steven R. and Jančálek, Radim and Růžička, Filip and Shamie, Nick A. and Smrčka, Martin and Wang, Jeffrey C. and Birkenmaier, Christof and Slabý, Ondřej}, article_location = {NEW YORK}, article_number = {4}, doi = {http://dx.doi.org/10.1007/s00586-018-5838-z}, keywords = {Propionibacterium acnes; Cutibacterium acnes; Degenerative disc disease; Biofilm; Cefazolin; Clindamycin; Vancomycin; Surgical prophylaxis}, language = {eng}, issn = {0940-6719}, journal = {European Spine Journal}, title = {Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections}, url = {https://link.springer.com/content/pdf/10.1007/s00586-018-5838-z.pdf}, volume = {28}, year = {2019} }
TY - JOUR ID - 1522757 AU - Capoor, Manu - Lochman, Jan - McDowell, Andrew - Schmitz, Jonathan E. - Solanský, Martin - Zapletalová, Martina - Alamin, Todd F. - Coscia, Michael F. - Garfin, Steven R. - Jančálek, Radim - Růžička, Filip - Shamie, Nick A. - Smrčka, Martin - Wang, Jeffrey C. - Birkenmaier, Christof - Slabý, Ondřej PY - 2019 TI - Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections JF - European Spine Journal VL - 28 IS - 4 SP - 783-791 EP - 783-791 PB - Springer SN - 09406719 KW - Propionibacterium acnes KW - Cutibacterium acnes KW - Degenerative disc disease KW - Biofilm KW - Cefazolin KW - Clindamycin KW - Vancomycin KW - Surgical prophylaxis UR - https://link.springer.com/content/pdf/10.1007/s00586-018-5838-z.pdf L2 - https://link.springer.com/content/pdf/10.1007/s00586-018-5838-z.pdf N2 - PurposeThe presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate the pathology of degenerative disc disease. This hypothesis, therefore, raises the exciting possibility that antibiotics could play an important role in treating this debilitating condition. To date, however, little information about antibiotic penetration into the intervertebral disc is available. MethodsIntervertebral disc tissue obtained from 54 microdiscectomy patients given prophylactic cefazolin (n=25), clindamycin (n=17) or vancomycin (n=12) was assayed by high-performance liquid chromatography, with cefaclor as an internal standard, to determine the concentration of antibiotic penetrating into the disc tissue.ResultsIntervertebral disc tissues from patients receiving the positively charged antibiotic clindamycin contained a significantly greater percentage of the antibacterial dose than the tissue from patients receiving negatively charged cefazolin (P<0.0001) and vancomycin, which has a slight positive charge (P<0.0001).ConclusionPositively charged antibiotics appear more appropriate for future studies investigating potential options for the treatment of low-virulence disc infections. [GRAPHICS] ER -
CAPOOR, Manu, Jan LOCHMAN, Andrew MCDOWELL, Jonathan E. SCHMITZ, Martin SOLANSKÝ, Martina ZAPLETALOVÁ, Todd F. ALAMIN, Michael F. COSCIA, Steven R. GARFIN, Radim JANČÁLEK, Filip RŮŽIČKA, Nick A. SHAMIE, Martin SMRČKA, Jeffrey C. WANG, Christof BIRKENMAIER a Ondřej SLABÝ. Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections. \textit{European Spine Journal}. NEW YORK: Springer, 2019, roč.~28, č.~4, s.~783-791. ISSN~0940-6719. Dostupné z: https://dx.doi.org/10.1007/s00586-018-5838-z.
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