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@article{1523596,
author = {Žák, Petr and Souček, Miroslav},
article_location = {Prague},
article_number = {3},
doi = {http://dx.doi.org/10.33549/physiolres.934002},
keywords = {cytokine IL-6; Il-10; TNF alpha},
language = {eng},
issn = {0862-8408},
journal = {Physiological Research},
title = {Correlation of tumor necrosis factor alpha, interleukin 6 and interleukin 10 with blood pressure, risk of preeclampsia and low birth weight in gestational diabetes},
url = {https://www.biomed.cas.cz/physiolres/pdf/prepress/934002.pdf},
volume = {68},
year = {2019}
}
TY - JOUR
ID - 1523596
AU - Žák, Petr - Souček, Miroslav
PY - 2019
TI - Correlation of tumor necrosis factor alpha, interleukin 6 and interleukin 10 with blood pressure, risk of preeclampsia and low birth weight in gestational diabetes
JF - Physiological Research
VL - 68
IS - 3
SP - 395-408
EP - 395-408
PB - AV ČR, Institute of Physiology
SN - 08628408
KW - cytokine IL-6
KW - Il-10
KW - TNF alpha
UR - https://www.biomed.cas.cz/physiolres/pdf/prepress/934002.pdf
L2 - https://www.biomed.cas.cz/physiolres/pdf/prepress/934002.pdf
N2 - Several pathophysiological mechanisms have been proposed in the development of pregnancy complications, including endothelial dysfunction, an inflammatory pathway and oxidative stress. The aim of the present study was to evaluate the correlation between proinflammatory cytokines TNF-alpha, IL-6 and dual cytokine IL-10 in the mother's peripheral blood and systolic blood pressure, risk of preeclampsia and low birth weight in gestational diabetes (GDM). We observed 40 women with GDM divided into a gestational hypertension group (n=20) and comparison group (n=20) with normal blood pressure. We found a significant positive correlation between TNF-alpha; IL-6; IL-10 levels and systolic blood pressure (SBP) in the second trimester (p<0.001; p<0.001; p<0.001); the third trimester (p<0.001; p<0.001; p<0.05). We also proved correlations for diastolic blood pressure (DBP) during the second; third trimester (p<0.001; p<0.001; p<0.001); (p<0.001; p<0.001; p<0.0015). We demonstrated a statistically significant positive association between high TNF-alpha group and preeclampsia risk in the third trimester (p=0.04). We also determined the negative correlation in the second trimester between birth weight and TNF-alpha; IL-6, IL-10 levels (p<0.05; p<0.001; p<0.001). To conclude, our data highlight the importance of cytokines TNF-alpha, IL-6 and IL-10 in blood pressure regulation. In addition, high levels of TNF-alpha have been associated with increased risk of preeclampsia. We found a significant negative correlation between levels of TNF-alpha, IL-6, IL-10 and birth weight.
ER -
ŽÁK, Petr a Miroslav SOUČEK. Correlation of tumor necrosis factor alpha, interleukin 6 and interleukin 10 with blood pressure, risk of preeclampsia and low birth weight in gestational diabetes. \textit{Physiological Research}. Prague: AV ČR, Institute of Physiology, 2019, roč.~68, č.~3, s.~395-408. ISSN~0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.934002.
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