HSPB7 GENE POLYMORPHISM ASSOCIATED WITH ANTHROPOMETRIC
PARAMETERS OF OBESITY AND FAT INTAKE IN A CENTRAL EUROPEAN
POPULATION

J 2018

HSPB7 GENE POLYMORPHISM ASSOCIATED WITH ANTHROPOMETRIC PARAMETERS OF OBESITY AND FAT INTAKE IN A CENTRAL EUROPEAN POPULATION

PAVLOVÁ, Tereza, Jan NOVÁK, Filip ZLÁMAL a Julie DOBROVOLNÁ

Základní údaje

Originální název

HSPB7 GENE POLYMORPHISM ASSOCIATED WITH ANTHROPOMETRIC PARAMETERS OF OBESITY AND FAT INTAKE IN A CENTRAL EUROPEAN POPULATION

Autoři

PAVLOVÁ, Tereza (203 Česká republika, garant, domácí), Jan NOVÁK (203 Česká republika, domácí), Filip ZLÁMAL (203 Česká republika, domácí) a Julie DOBROVOLNÁ (203 Česká republika, domácí)

Vydání

Central European journal of public health, Praha, Česká lékařská společnost J.E. Purkyně, 2018, 1210-7778

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 0.636

Kód RIV

RIV/00216224:14310/18:00106852

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.21101/cejph.a4921

UT WoS

000463167100005

Klíčová slova anglicky

HSPB7; obesity; polymorphism; dietary composition; fat intake; rs1048261

Štítky

14110515, 14110518, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 4. 2024 14:47, Mgr. Michal Petr

Anotace

V originále

Objective: Heat shock proteins act as chaperones at the molecular level and therefore they have been investigated in numerous diseases associated with oxidative stress, including obesity. The aim of this study was to investigate the possible associations of genetic variability in the 3'-untranslated region of the HSPB7 gene (rs1048261) with anthropometric and dietary parameters in a cohort of lean and obese Central European subjects. Methods: A total of 708 Central European Caucasian individuals were enrolled in this study, 415 obese subjects and 293 non-obese subjects. The rs1048261 genotypes were established using a conventional PCR-based methodology. Results: Significant differences were observed in the total daily fat intake between subjects with AT and TT genotypes (82.6 +/- 29.2 g vs. 74.1 +/- 31.3 g, p = 0.023) and also borderline significance in daily proportion of fat in the diet between AA and TT genotypes (36.0 +/- 4.4% vs. 33.3 +/- 5.9%, p = 0.061). Based on the linear regression model we found association between rs1048261 genotype and body fat percentage. Conclusions: To the best of our knowledge, this is the first study which reports an association of defined genetic variability in the HSPB7 gene, rs1048261, with obesity and its associated anthropometric characteristics and dietary composition.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

PAVLOVÁ, Tereza, Jan NOVÁK, Filip ZLÁMAL a Julie DOBROVOLNÁ. HSPB7 GENE POLYMORPHISM ASSOCIATED WITH ANTHROPOMETRIC PARAMETERS OF OBESITY AND FAT INTAKE IN A CENTRAL EUROPEAN POPULATION. Central European journal of public health. Praha: Česká lékařská společnost J.E. Purkyně, 2018, roč. 26, č. 4, s. 272-277. ISSN 1210-7778. Dostupné z: https://dx.doi.org/10.21101/cejph.a4921.

@article{1526356,
   author = {Pavlová, Tereza and Novák, Jan and Zlámal, Filip and Dobrovolná, Julie},
   article_location = {Praha},
   article_number = {4},
   doi = {http://dx.doi.org/10.21101/cejph.a4921},
   keywords = {HSPB7; obesity; polymorphism; dietary composition; fat intake; rs1048261},
   language = {eng},
   issn = {1210-7778},
   journal = {Central European journal of public health},
   title = {HSPB7 GENE POLYMORPHISM ASSOCIATED WITH ANTHROPOMETRIC PARAMETERS OF OBESITY AND FAT INTAKE IN A CENTRAL EUROPEAN POPULATION},
   url = {http://dx.doi.org/10.21101/cejph.a4921},
   volume = {26},
   year = {2018}
}

TY  - JOUR
ID  - 1526356
AU  - Pavlová, Tereza - Novák, Jan - Zlámal, Filip - Dobrovolná, Julie
PY  - 2018
TI  - HSPB7 GENE POLYMORPHISM ASSOCIATED WITH ANTHROPOMETRIC PARAMETERS OF OBESITY AND FAT INTAKE IN A CENTRAL EUROPEAN POPULATION
JF  - Central European journal of public health
VL  - 26
IS  - 4
SP  - 272-277
EP  - 272-277
PB  - Česká lékařská společnost J.E. Purkyně
SN  - 12107778
KW  - HSPB7
KW  - obesity
KW  - polymorphism
KW  - dietary composition
KW  - fat intake
KW  - rs1048261
UR  - http://dx.doi.org/10.21101/cejph.a4921
N2  - Objective: Heat shock proteins act as chaperones at the molecular level and therefore they have been investigated in numerous diseases associated with oxidative stress, including obesity. The aim of this study was to investigate the possible associations of genetic variability in the 3'-untranslated region of the HSPB7 gene (rs1048261) with anthropometric and dietary parameters in a cohort of lean and obese Central European subjects. Methods: A total of 708 Central European Caucasian individuals were enrolled in this study, 415 obese subjects and 293 non-obese subjects. The rs1048261 genotypes were established using a conventional PCR-based methodology. Results: Significant differences were observed in the total daily fat intake between subjects with AT and TT genotypes (82.6 +/- 29.2 g vs. 74.1 +/- 31.3 g, p = 0.023) and also borderline significance in daily proportion of fat in the diet between AA and TT genotypes (36.0 +/- 4.4% vs. 33.3 +/- 5.9%, p = 0.061). Based on the linear regression model we found association between rs1048261 genotype and body fat percentage. Conclusions: To the best of our knowledge, this is the first study which reports an association of defined genetic variability in the HSPB7 gene, rs1048261, with obesity and its associated anthropometric characteristics and dietary composition.
ER  -

PAVLOVÁ, Tereza, Jan NOVÁK, Filip ZLÁMAL a Julie DOBROVOLNÁ. HSPB7 GENE POLYMORPHISM ASSOCIATED WITH ANTHROPOMETRIC PARAMETERS OF OBESITY AND FAT INTAKE IN A CENTRAL EUROPEAN POPULATION. \textit{Central European journal of public health}. Praha: Česká lékařská společnost J.E. Purkyně, 2018, roč.~26, č.~4, s.~272-277. ISSN~1210-7778. Dostupné z: https://dx.doi.org/10.21101/cejph.a4921.

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