Plasma bio-adrenomedullin is a marker of acute heart failure
severity in patients with acute coronary syndrome

J 2019

Plasma bio-adrenomedullin is a marker of acute heart failure severity in patients with acute coronary syndrome

ARRIGO, Mattia, Jiří PAŘENICA, Eva GANOVSKÁ, Marie PAVLUSOVA, Alexander MEBAZAA et. al.

Základní údaje

Originální název

Plasma bio-adrenomedullin is a marker of acute heart failure severity in patients with acute coronary syndrome

Autoři

ARRIGO, Mattia (250 Francie, garant), Jiří PAŘENICA (203 Česká republika, domácí), Eva GANOVSKÁ (703 Slovensko), Marie PAVLUSOVA (203 Česká republika) a Alexander MEBAZAA (250 Francie)

Vydání

IJC HEART & VASCULATURE, CLARE, ELSEVIER IRELAND LTD, 2019, 2352-9067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14110/19:00109543

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.ijcha.2019.02.011

UT WoS

000462184100037

Klíčová slova anglicky

Bio-adrenomedullin; Acute coronary syndrome; Acute heart failure; Pulmonary edema

Štítky

14110211, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 5. 2020 09:13, Mgr. Tereza Miškechová

Anotace

V originále

Background: The assessment of acute heart failure (AHF) in patients with acute coronary syndrome (ACS) is challenging. This study tested whether measuring plasma adrenomedullin in patients admitted for ACS provides valuable information regarding the presence of AHF at admission or its occurrence during hospitalization. Methods and results: The study population consisted of 927 prospectively enrolled patients with ACS. Blood samples for the measurement of plasma bio-adrenomedullin (bio-ADM) were collected at admission. Patients with alveolar pulmonary edema and interstitial pulmonary edema on chest radiography at admission had step-wise higher plasma concentrations of bio-ADM compared to patients with no or mild pulmonary congestion: 54.3 +/- 10.6 vs. 27.6 +/- 2.1 vs. 22.5 +/- 0.7 ng/L, overall P < 0.001. Patients with ACS complicated by AHF during the index hospitalization displayed higher plasma bio-ADM concentrations at admission compared to patients without AHF (33.8 +/- 2.7 vs. 21.8 +/- 0.7, P < 0.001): the higher the severity of AHF, the higher plasma bio-ADM concentrations at admission. Patients with cardiogenic shock displayed the highest values. Accordingly, bio-ADM concentrations at admission were associated with a higher risk of occurrence of AHF during index hospitalization (odds ratio 1.018, 95% confidence interval 1.011-1.026, P < 0.001). Conclusions: Plasma adrenomedullin is a marker associated with AHF severity in patients with ACS. (c) 2019 Published by Elsevier B.V.

Návaznosti

MUNI/A/1250/2017, interní kód MU

Název: Validace Rule-out/rule-in protokolu u pacientů s bolestí na hrudi – pokračování v prospektivní studii

Investor: Masarykova univerzita, Validace Rule-out/rule-in protokolu u pacientů s bolestí na hrudi – pokračování v prospektivní studii, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

ARRIGO, Mattia, Jiří PAŘENICA, Eva GANOVSKÁ, Marie PAVLUSOVA a Alexander MEBAZAA. Plasma bio-adrenomedullin is a marker of acute heart failure severity in patients with acute coronary syndrome. IJC HEART & VASCULATURE. CLARE: ELSEVIER IRELAND LTD, 2019, roč. 22, MAR 2019, s. 174-176. ISSN 2352-9067. Dostupné z: https://dx.doi.org/10.1016/j.ijcha.2019.02.011.

@article{1527041,
   author = {Arrigo, Mattia and Pařenica, Jiří and Ganovská, Eva and Pavlusova, Marie and Mebazaa, Alexander},
   article_location = {CLARE},
   article_number = {MAR 2019},
   doi = {http://dx.doi.org/10.1016/j.ijcha.2019.02.011},
   keywords = {Bio-adrenomedullin; Acute coronary syndrome; Acute heart failure; Pulmonary edema},
   language = {eng},
   issn = {2352-9067},
   journal = {IJC HEART & VASCULATURE},
   title = {Plasma bio-adrenomedullin is a marker of acute heart failure severity in patients with acute coronary syndrome},
   url = {http://dx.doi.org/10.1016/j.ijcha.2019.02.011},
   volume = {22},
   year = {2019}
}

TY  - JOUR
ID  - 1527041
AU  - Arrigo, Mattia - Pařenica, Jiří - Ganovská, Eva - Pavlusova, Marie - Mebazaa, Alexander
PY  - 2019
TI  - Plasma bio-adrenomedullin is a marker of acute heart failure severity in patients with acute coronary syndrome
JF  - IJC HEART & VASCULATURE
VL  - 22
IS  - MAR 2019
SP  - 174-176
EP  - 174-176
PB  - ELSEVIER IRELAND LTD
SN  - 23529067
KW  - Bio-adrenomedullin
KW  - Acute coronary syndrome
KW  - Acute heart failure
KW  - Pulmonary edema
UR  - http://dx.doi.org/10.1016/j.ijcha.2019.02.011
L2  - http://dx.doi.org/10.1016/j.ijcha.2019.02.011
N2  - Background: The assessment of acute heart failure (AHF) in patients with acute coronary syndrome (ACS) is challenging. This study tested whether measuring plasma adrenomedullin in patients admitted for ACS provides valuable information regarding the presence of AHF at admission or its occurrence during hospitalization. Methods and results: The study population consisted of 927 prospectively enrolled patients with ACS. Blood samples for the measurement of plasma bio-adrenomedullin (bio-ADM) were collected at admission. Patients with alveolar pulmonary edema and interstitial pulmonary edema on chest radiography at admission had step-wise higher plasma concentrations of bio-ADM compared to patients with no or mild pulmonary congestion: 54.3 +/- 10.6 vs. 27.6 +/- 2.1 vs. 22.5 +/- 0.7 ng/L, overall P < 0.001. Patients with ACS complicated by AHF during the index hospitalization displayed higher plasma bio-ADM concentrations at admission compared to patients without AHF (33.8 +/- 2.7 vs. 21.8 +/- 0.7, P < 0.001): the higher the severity of AHF, the higher plasma bio-ADM concentrations at admission. Patients with cardiogenic shock displayed the highest values. Accordingly, bio-ADM concentrations at admission were associated with a higher risk of occurrence of AHF during index hospitalization (odds ratio 1.018, 95% confidence interval 1.011-1.026, P < 0.001). Conclusions: Plasma adrenomedullin is a marker associated with AHF severity in patients with ACS. (c) 2019 Published by Elsevier B.V.
ER  -

ARRIGO, Mattia, Jiří PAŘENICA, Eva GANOVSKÁ, Marie PAVLUSOVA a Alexander MEBAZAA. Plasma bio-adrenomedullin is a marker of acute heart failure severity in patients with acute coronary syndrome. \textit{IJC HEART \&{}amp; VASCULATURE}. CLARE: ELSEVIER IRELAND LTD, 2019, roč.~22, MAR 2019, s.~174-176. ISSN~2352-9067. Dostupné z: https://dx.doi.org/10.1016/j.ijcha.2019.02.011.

Podrobný výpis o publikaci