Cardiopulmonary exercise testing for identification of patients
with hyperventilation syndrome

J 2019

Cardiopulmonary exercise testing for identification of patients with hyperventilation syndrome

BRAT, Kristián, Nela ŠŤASTNÁ, Zdeněk MERTA, Lyle J. OLSON, Bruce D. JOHNSON et. al.

Základní údaje

Originální název

Cardiopulmonary exercise testing for identification of patients with hyperventilation syndrome

Autoři

BRAT, Kristián (703 Slovensko, domácí), Nela ŠŤASTNÁ (203 Česká republika, domácí), Zdeněk MERTA (203 Česká republika, domácí), Lyle J. OLSON (840 Spojené státy), Bruce D. JOHNSON (840 Spojené státy) a Ivan ČUNDRLE (203 Česká republika, garant, domácí)

Vydání

Plos one, San Francisco, Public Library of Science, 2019, 1932-6203

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30203 Respiratory systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.740

Kód RIV

RIV/00216224:14110/19:00109665

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1371/journal.pone.0215997

UT WoS

000465223900061

Klíčová slova anglicky

hyperventilation syndrome

Štítky

14110122, 14110215, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 5. 2019 13:19, Soňa Böhmová

Anotace

V originále

Introduction Measurement of ventilatory efficiency, defined as minute ventilation per unit carbon dioxide production (V-E/VCO2), by cardiopulmonary exercise testing (CPET) has been proposed as a screen for hyperventilation syndrome (HVS). However, increased V-E/VCO2 may be associated with other disorders which need to be distinguished from HVS. A more specific marker of HVS by CPET would be clinically useful. We hypothesized ventilatory control during exercise is abnormal in patients with HVS. Methods Patients who underwent CPET from years 2015 through 2017 were retrospectively identified and formed the study group. HVS was defined as dyspnea with respiratory alkalosis (pH >7.45) at peak exercise with absence of acute or chronic respiratory, heart or psychiatric disease. Healthy patients were selected as controls. For comparison the Student t-test or Mann-Whitney U test were used. Data are summarized as mean +/- SD or median (IQR); p<0.05 was considered significant. Results Twenty-nine patients with HVS were identified and 29 control subjects were selected. At rest, end-tidal carbon dioxide (PETCO2) was 27 mmHg (25-30) for HVS patients vs. 30 mmHg (28-32); in controls (p = 0.05). At peak exercise PETCO2 was also significantly lower (27 +/- 4 mmHg vs. 35 +/- 4 mmHg; p< 0.01) and V-E/VCO2 higher ((38 (35-43) vs. 31 (27-34); p< 0.01)) in patients with HVS. In contrast to controls, there were minimal changes of PETCO2 (0.50 +/- 5.26 mmHg vs. 6.2 +/- 4.6 mmHg; p< 0.01) and V-E/VCO2 ((0.17 (-4.24-6.02) vs. -6.6 (-11.4-(-2.8)); p< 0.01)) during exercise in patients with HVS. The absence of V-E/VCO2 and PETCO2 change during exercise was specific for HVS (83% and 93%, respectively). Conclusion Absence of V-E/VCO2 and PETCO2 change during exercise may identify patients with HVS.

Citovat

BRAT, Kristián, Nela ŠŤASTNÁ, Zdeněk MERTA, Lyle J. OLSON, Bruce D. JOHNSON a Ivan ČUNDRLE. Cardiopulmonary exercise testing for identification of patients with hyperventilation syndrome. Plos one. San Francisco: Public Library of Science, 2019, roč. 14, č. 4, s. 1-13. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0215997.

@article{1531366,
   author = {Brat, Kristián and Šťastná, Nela and Merta, Zdeněk and Olson, Lyle J. and Johnson, Bruce D. and Čundrle, Ivan},
   article_location = {San Francisco},
   article_number = {4},
   doi = {http://dx.doi.org/10.1371/journal.pone.0215997},
   keywords = {hyperventilation syndrome},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {Cardiopulmonary exercise testing for identification of patients with hyperventilation syndrome},
   url = {http://dx.doi.org/10.1371/journal.pone.0215997},
   volume = {14},
   year = {2019}
}

TY  - JOUR
ID  - 1531366
AU  - Brat, Kristián - Šťastná, Nela - Merta, Zdeněk - Olson, Lyle J. - Johnson, Bruce D. - Čundrle, Ivan
PY  - 2019
TI  - Cardiopulmonary exercise testing for identification of patients with hyperventilation syndrome
JF  - Plos one
VL  - 14
IS  - 4
SP  - 1-13
EP  - 1-13
PB  - Public Library of Science
SN  - 19326203
KW  - hyperventilation syndrome
UR  - http://dx.doi.org/10.1371/journal.pone.0215997
L2  - http://dx.doi.org/10.1371/journal.pone.0215997
N2  - Introduction Measurement of ventilatory efficiency, defined as minute ventilation per unit carbon dioxide production (V-E/VCO2), by cardiopulmonary exercise testing (CPET) has been proposed as a screen for hyperventilation syndrome (HVS). However, increased V-E/VCO2 may be associated with other disorders which need to be distinguished from HVS. A more specific marker of HVS by CPET would be clinically useful. We hypothesized ventilatory control during exercise is abnormal in patients with HVS. Methods Patients who underwent CPET from years 2015 through 2017 were retrospectively identified and formed the study group. HVS was defined as dyspnea with respiratory alkalosis (pH >7.45) at peak exercise with absence of acute or chronic respiratory, heart or psychiatric disease. Healthy patients were selected as controls. For comparison the Student t-test or Mann-Whitney U test were used. Data are summarized as mean +/- SD or median (IQR); p<0.05 was considered significant. Results Twenty-nine patients with HVS were identified and 29 control subjects were selected. At rest, end-tidal carbon dioxide (PETCO2) was 27 mmHg (25-30) for HVS patients vs. 30 mmHg (28-32); in controls (p = 0.05). At peak exercise PETCO2 was also significantly lower (27 +/- 4 mmHg vs. 35 +/- 4 mmHg; p< 0.01) and V-E/VCO2 higher ((38 (35-43) vs. 31 (27-34); p< 0.01)) in patients with HVS. In contrast to controls, there were minimal changes of PETCO2 (0.50 +/- 5.26 mmHg vs. 6.2 +/- 4.6 mmHg; p< 0.01) and V-E/VCO2 ((0.17 (-4.24-6.02) vs. -6.6 (-11.4-(-2.8)); p< 0.01)) during exercise in patients with HVS. The absence of V-E/VCO2 and PETCO2 change during exercise was specific for HVS (83% and 93%, respectively). Conclusion Absence of V-E/VCO2 and PETCO2 change during exercise may identify patients with HVS.
ER  -

BRAT, Kristián, Nela ŠŤASTNÁ, Zdeněk MERTA, Lyle J. OLSON, Bruce D. JOHNSON a Ivan ČUNDRLE. Cardiopulmonary exercise testing for identification of patients with hyperventilation syndrome. \textit{Plos one}. San Francisco: Public Library of Science, 2019, roč.~14, č.~4, s.~1-13. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0215997.

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