Elevated Sera sST2 Is Associated With Heart Failure in Men <=
50 Years Old With Myocarditis

J 2019

Elevated Sera sST2 Is Associated With Heart Failure in Men <= 50 Years Old With Myocarditis

CORONADO, Michael J., Katelyn A. BRUNO, Lori A. BLAUWET, Carsten TSCHOPE, Madeleine W. CUNNINGHAM et. al.

Základní údaje

Originální název

Elevated Sera sST2 Is Associated With Heart Failure in Men <= 50 Years Old With Myocarditis

Autoři

CORONADO, Michael J. (840 Spojené státy), Katelyn A. BRUNO (840 Spojené státy), Lori A. BLAUWET (840 Spojené státy), Carsten TSCHOPE (276 Německo), Madeleine W. CUNNINGHAM (840 Spojené státy), Sabine PANKUWEIT (276 Německo), Sophie VAN LINTHOUT (276 Německo), Eun Seok JEON (410 Korejská republika), Dennis M. MCNAMARA (840 Spojené státy), Jan KREJČÍ (203 Česká republika, domácí), Julie DOBROVOLNÁ (203 Česká republika, garant, domácí), Erika J. DOUGLASS (840 Spojené státy), Eric D. ABSTON (840 Spojené státy), Adriana BUCEK (840 Spojené státy), Augusto J. FRISANCHO (840 Spojené státy), Merci S. GREENAWAY (840 Spojené státy), Anneliese R. HILL (840 Spojené státy), Heinz P. SCHULTHEISS (276 Německo), Leslie T. COOPER (840 Spojené státy) a DeLisa FAIRWEATHER (840 Spojené státy)

Vydání

Journal of the American Heart Association, Hoboken, Wiley-Blackwell, 2019, 2047-9980

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.605

Kód RIV

RIV/00216224:14110/19:00109668

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1161/JAHA.118.008968

UT WoS

000460105800002

Klíčová slova anglicky

biomarkers; heart failure; myocarditis; sex differences; sST2

Štítky

14110115, 14110518, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 3. 2020 15:28, Mgr. Tereza Miškechová

Anotace

V originále

Background Myocarditis is an important cause of acute and chronic heart failure. Men with myocarditis have worse recovery and an increased need for transplantation compared with women, but the reason for the sex difference remains unclear. Elevated sera soluble (s)ST2 predicts mortality from acute and chronic heart failure, but has not been studied in myocarditis patients. Methods and Results Adults with a diagnosis of clinically suspected myocarditis (n=303, 78% male) were identified according to the 2013 European Society of Cardiology position statement. Sera sST2 levels were examined by ELISA in humans and mice and correlated with heart function according to sex and age. Sera sST2 levels were higher in healthy men (P=8 x 10(-6)) and men with myocarditis (P=0.004) compared with women. sST2 levels were elevated in patients with myocarditis and New York Heart Association class III-IV heart failure (P=0.002), predominantly in men (P=0.0003). Sera sST2 levels were associated with New York Heart Association class in men with myocarditis who were <= 50 years old (r=0.231, P=0.0006), but not in women (r=0.172, P=0.57). Sera sST2 levels were also significantly higher in male mice with myocarditis (P=0.005) where levels were associated with cardiac inflammation. Gonadectomy with hormone replacement showed that testosterone (P<0.001), but not estradiol (P=0.32), increased sera sST2 levels in male mice with myocarditis. Conclusions We show in a well-characterized subset of heart failure patients with clinically suspected and biopsy-confirmed myocarditis that elevated sera sST2 is associated with an increased risk of heart failure based on New York Heart Association class in men <= 50 years old.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

MUNI/A/1553/2018, interní kód MU

Název: Genetické, environmentální a tkáňové charakteristiky vybraných patologických stavů a nemocí (Akronym: genetika; stres; biomateriály; tkáňové kultury)

Investor: Masarykova univerzita, Genetické, environmentální a tkáňové charakteristiky vybraných patologických stavů a nemocí, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

CORONADO, Michael J., Katelyn A. BRUNO, Lori A. BLAUWET, Carsten TSCHOPE, Madeleine W. CUNNINGHAM, Sabine PANKUWEIT, Sophie VAN LINTHOUT, Eun Seok JEON, Dennis M. MCNAMARA, Jan KREJČÍ, Julie DOBROVOLNÁ, Erika J. DOUGLASS, Eric D. ABSTON, Adriana BUCEK, Augusto J. FRISANCHO, Merci S. GREENAWAY, Anneliese R. HILL, Heinz P. SCHULTHEISS, Leslie T. COOPER a DeLisa FAIRWEATHER. Elevated Sera sST2 Is Associated With Heart Failure in Men <= 50 Years Old With Myocarditis. Journal of the American Heart Association. Hoboken: Wiley-Blackwell, 2019, roč. 8, č. 2, s. 1-16. ISSN 2047-9980. Dostupné z: https://dx.doi.org/10.1161/JAHA.118.008968.

@article{1531398,
   author = {Coronado, Michael J. and Bruno, Katelyn A. and Blauwet, Lori A. and Tschope, Carsten and Cunningham, Madeleine W. and Pankuweit, Sabine and van Linthout, Sophie and Jeon, Eun Seok and McNamara, Dennis M. and Krejčí, Jan and Dobrovolná, Julie and Douglass, Erika J. and Abston, Eric D. and Bucek, Adriana and Frisancho, Augusto J. and Greenaway, Merci S. and Hill, Anneliese R. and Schultheiss, Heinz P. and Cooper, Leslie T. and Fairweather, DeLisa},
   article_location = {Hoboken},
   article_number = {2},
   doi = {http://dx.doi.org/10.1161/JAHA.118.008968},
   keywords = {biomarkers; heart failure; myocarditis; sex differences; sST2},
   language = {eng},
   issn = {2047-9980},
   journal = {Journal of the American Heart Association},
   title = {Elevated Sera sST2 Is Associated With Heart Failure in Men <= 50 Years Old With Myocarditis},
   url = {https://www.ahajournals.org/doi/10.1161/JAHA.118.008968},
   volume = {8},
   year = {2019}
}

TY  - JOUR
ID  - 1531398
AU  - Coronado, Michael J. - Bruno, Katelyn A. - Blauwet, Lori A. - Tschope, Carsten - Cunningham, Madeleine W. - Pankuweit, Sabine - van Linthout, Sophie - Jeon, Eun Seok - McNamara, Dennis M. - Krejčí, Jan - Dobrovolná, Julie - Douglass, Erika J. - Abston, Eric D. - Bucek, Adriana - Frisancho, Augusto J. - Greenaway, Merci S. - Hill, Anneliese R. - Schultheiss, Heinz P. - Cooper, Leslie T. - Fairweather, DeLisa
PY  - 2019
TI  - Elevated Sera sST2 Is Associated With Heart Failure in Men <= 50 Years Old With Myocarditis
JF  - Journal of the American Heart Association
VL  - 8
IS  - 2
SP  - 1-16
EP  - 1-16
PB  - Wiley-Blackwell
SN  - 20479980
KW  - biomarkers
KW  - heart failure
KW  - myocarditis
KW  - sex differences
KW  - sST2
UR  - https://www.ahajournals.org/doi/10.1161/JAHA.118.008968
L2  - https://www.ahajournals.org/doi/10.1161/JAHA.118.008968
N2  - Background Myocarditis is an important cause of acute and chronic heart failure. Men with myocarditis have worse recovery and an increased need for transplantation compared with women, but the reason for the sex difference remains unclear. Elevated sera soluble (s)ST2 predicts mortality from acute and chronic heart failure, but has not been studied in myocarditis patients. Methods and Results Adults with a diagnosis of clinically suspected myocarditis (n=303, 78% male) were identified according to the 2013 European Society of Cardiology position statement. Sera sST2 levels were examined by ELISA in humans and mice and correlated with heart function according to sex and age. Sera sST2 levels were higher in healthy men (P=8 x 10(-6)) and men with myocarditis (P=0.004) compared with women. sST2 levels were elevated in patients with myocarditis and New York Heart Association class III-IV heart failure (P=0.002), predominantly in men (P=0.0003). Sera sST2 levels were associated with New York Heart Association class in men with myocarditis who were <= 50 years old (r=0.231, P=0.0006), but not in women (r=0.172, P=0.57). Sera sST2 levels were also significantly higher in male mice with myocarditis (P=0.005) where levels were associated with cardiac inflammation. Gonadectomy with hormone replacement showed that testosterone (P<0.001), but not estradiol (P=0.32), increased sera sST2 levels in male mice with myocarditis. Conclusions We show in a well-characterized subset of heart failure patients with clinically suspected and biopsy-confirmed myocarditis that elevated sera sST2 is associated with an increased risk of heart failure based on New York Heart Association class in men <= 50 years old.
ER  -

CORONADO, Michael J., Katelyn A. BRUNO, Lori A. BLAUWET, Carsten TSCHOPE, Madeleine W. CUNNINGHAM, Sabine PANKUWEIT, Sophie VAN LINTHOUT, Eun Seok JEON, Dennis M. MCNAMARA, Jan KREJČÍ, Julie DOBROVOLNÁ, Erika J. DOUGLASS, Eric D. ABSTON, Adriana BUCEK, Augusto J. FRISANCHO, Merci S. GREENAWAY, Anneliese R. HILL, Heinz P. SCHULTHEISS, Leslie T. COOPER a DeLisa FAIRWEATHER. Elevated Sera sST2 Is Associated With Heart Failure in Men \&{}lt;= 50 Years Old With Myocarditis. \textit{Journal of the American Heart Association}. Hoboken: Wiley-Blackwell, 2019, roč.~8, č.~2, s.~1-16. ISSN~2047-9980. Dostupné z: https://dx.doi.org/10.1161/JAHA.118.008968.

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