| BOSÁKOVÁ, Michaela, Alexandru NITĂ, Tomáš GREGOR, Miroslav VAŘECHA, Iva GUDERNOVÁ, Bohumil FAFÍLEK, Tomáš BÁRTA, Neha BASHEER, Sara POOVAKULATHU ABRAHAM, Lukáš BÁLEK, Markéta TOMANOVÁ, Jana FIALOVÁ KUČEROVÁ, Juraj BOSÁK, David POTĚŠIL, Jennifer ZIEBA, Jieun SONG, Peter KONIK, Sohyun PARK, Ivan DURAN, Zbyněk ZDRÁHAL, David ŠMAJS, Gert JANSEN, Zheng FU, Hyuk Wan KO, Aleš HAMPL, Lukáš TRANTÍREK, Deborah KRAKOW and Pavel KREJČÍ. Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase. Proceedings of the National Academy of Sciences of the United States of America. WASHINGTON: NATL ACAD SCIENCES, 2019, vol. 116, No 10, p. 4316-4325. ISSN 0027-8424. Available from: https://dx.doi.org/10.1073/pnas.1800338116. |
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@article{1531598,
author = {Bosáková, Michaela and Nită, Alexandru and Gregor, Tomáš and Vařecha, Miroslav and Gudernová, Iva and Fafílek, Bohumil and Bárta, Tomáš and Basheer, Neha and Poovakulathu Abraham, Sara and Bálek, Lukáš and Tomanová, Markéta and Fialová Kučerová, Jana and Bosák, Juraj and Potěšil, David and Zieba, Jennifer and Song, Jieun and Konik, Peter and Park, Sohyun and Duran, Ivan and Zdráhal, Zbyněk and Šmajs, David and Jansen, Gert and Fu, Zheng and Ko, Hyuk Wan and Hampl, Aleš and Trantírek, Lukáš and Krakow, Deborah and Krejčí, Pavel},
article_location = {WASHINGTON},
article_number = {10},
doi = {http://dx.doi.org/10.1073/pnas.1800338116},
keywords = {fibroblast growth factor; FGFR; intestinal cell kinase; ICK; cilia length},
language = {eng},
issn = {0027-8424},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
title = {Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase},
url = {https://www.pnas.org/content/pnas/116/10/4316.full.pdf},
volume = {116},
year = {2019}
}
TY - JOUR
ID - 1531598
AU - Bosáková, Michaela - Nită, Alexandru - Gregor, Tomáš - Vařecha, Miroslav - Gudernová, Iva - Fafílek, Bohumil - Bárta, Tomáš - Basheer, Neha - Poovakulathu Abraham, Sara - Bálek, Lukáš - Tomanová, Markéta - Fialová Kučerová, Jana - Bosák, Juraj - Potěšil, David - Zieba, Jennifer - Song, Jieun - Konik, Peter - Park, Sohyun - Duran, Ivan - Zdráhal, Zbyněk - Šmajs, David - Jansen, Gert - Fu, Zheng - Ko, Hyuk Wan - Hampl, Aleš - Trantírek, Lukáš - Krakow, Deborah - Krejčí, Pavel
PY - 2019
TI - Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase
JF - Proceedings of the National Academy of Sciences of the United States of America
VL - 116
IS - 10
SP - 4316-4325
EP - 4316-4325
PB - NATL ACAD SCIENCES
SN - 00278424
KW - fibroblast growth factor
KW - FGFR
KW - intestinal cell kinase
KW - ICK
KW - cilia length
UR - https://www.pnas.org/content/pnas/116/10/4316.full.pdf
L2 - https://www.pnas.org/content/pnas/116/10/4316.full.pdf
N2 - Vertebrate primary cilium is a Hedgehog signaling center but the extent of its involvement in other signaling systems is less well understood. This report delineates a mechanism by which fibroblast growth factor (FGF) controls primary cilia. Employing proteomic approaches to characterize proteins associated with the FGF-receptor, FGFR3, we identified the serine/threonine kinase intestinal cell kinase (ICK) as an FGFR interactor. ICK is involved in ciliogenesis and participates in control of ciliary length. FGF signaling partially abolished ICK's kinase activity, through FGFR-mediated ICK phosphorylation at conserved residue Tyr15, which interfered with optimal ATP binding. Activation of the FGF signaling pathway affected both primary cilia length and function in a manner consistent with cilia effects caused by inhibition of ICK activity. Moreover, knockdown and knockout of ICK rescued the FGF-mediated effect on cilia. We provide conclusive evidence that FGF signaling controls cilia via interaction with ICK.
ER -
BOSÁKOVÁ, Michaela, Alexandru NIT$\backslash$U A, Tomáš GREGOR, Miroslav VAŘECHA, Iva GUDERNOVÁ, Bohumil FAFÍLEK, Tomáš BÁRTA, Neha BASHEER, Sara POOVAKULATHU ABRAHAM, Lukáš BÁLEK, Markéta TOMANOVÁ, Jana FIALOVÁ KUČEROVÁ, Juraj BOSÁK, David POTĚŠIL, Jennifer ZIEBA, Jieun SONG, Peter KONIK, Sohyun PARK, Ivan DURAN, Zbyněk ZDRÁHAL, David ŠMAJS, Gert JANSEN, Zheng FU, Hyuk Wan KO, Aleš HAMPL, Lukáš TRANTÍREK, Deborah KRAKOW and Pavel KREJČÍ. Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase. \textit{Proceedings of the National Academy of Sciences of the United States of America}. WASHINGTON: NATL ACAD SCIENCES, 2019, vol.~116, No~10, p.~4316-4325. ISSN~0027-8424. Available from: https://dx.doi.org/10.1073/pnas.1800338116.
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