| KANDEROVA, V., H. GROMBIRIKOVA, I. ZENTSOVA, Kamila RÉBLOVÁ, A. KLOCPERK, M. FEJTKOVA, M. BLOOMFIELD, B. RAVCUKOVA, T. KALINA, Tomáš FREIBERGER a A. SEDIVA. Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8. Haematologica. PAVIA: FERRATA STORTI FOUNDATION, 2019, roč. 104, č. 1, s. "E32"-"E34", 3 s. ISSN 0390-6078. Dostupné z: https://dx.doi.org/10.3324/haematol.2018.201673. |
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@article{1531637,
author = {Kanderova, V. and Grombirikova, H. and Zentsova, I. and Réblová, Kamila and Klocperk, A. and Fejtkova, M. and Bloomfield, M. and Ravcukova, B. and Kalina, T. and Freiberger, Tomáš and Sediva, A.},
article_location = {PAVIA},
article_number = {1},
doi = {http://dx.doi.org/10.3324/haematol.2018.201673},
keywords = {ACTIVATION},
language = {eng},
issn = {0390-6078},
journal = {Haematologica},
title = {Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8},
url = {http://www.haematologica.org/content/haematol/104/1/e32.full.pdf},
volume = {104},
year = {2019}
}
TY - JOUR
ID - 1531637
AU - Kanderova, V. - Grombirikova, H. - Zentsova, I. - Réblová, Kamila - Klocperk, A. - Fejtkova, M. - Bloomfield, M. - Ravcukova, B. - Kalina, T. - Freiberger, Tomáš - Sediva, A.
PY - 2019
TI - Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8
JF - Haematologica
VL - 104
IS - 1
SP - "E32"-"E34"
EP - "E32"-"E34"
PB - FERRATA STORTI FOUNDATION
SN - 03906078
KW - ACTIVATION
UR - http://www.haematologica.org/content/haematol/104/1/e32.full.pdf
L2 - http://www.haematologica.org/content/haematol/104/1/e32.full.pdf
N2 - Caspase-8 is a member of the aspartate-specific cysteine protease family that is typically synthetized as an inactive zymogen and activated upon an appropriate stimulus. Caspase-8 plays an essential role in apoptotic signal transduction from the death receptor. Recruitment of procaspase-8 into the death signaling complex leads to its dimerization, autoproteolytic cleavage and formation of a highly active heterotetramer. Caspase-8 subsequently activates caspase-3, thereby initiating the proteolytic pathway, and ultimately resulting in the apoptotic disassembly of the cell.1 Additionally, caspase-8 is also essential for various immune processes, such as lymphocyte activation, inflammasome regulation and cytokine production
ER -
KANDEROVA, V., H. GROMBIRIKOVA, I. ZENTSOVA, Kamila RÉBLOVÁ, A. KLOCPERK, M. FEJTKOVA, M. BLOOMFIELD, B. RAVCUKOVA, T. KALINA, Tomáš FREIBERGER a A. SEDIVA. Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8. \textit{Haematologica}. PAVIA: FERRATA STORTI FOUNDATION, 2019, roč.~104, č.~1, s.~''E32''-''E34'', 3 s. ISSN~0390-6078. Dostupné z: https://dx.doi.org/10.3324/haematol.2018.201673.
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