Different effects of prenatal MAM vs. perinatal THC exposure on
regional cerebral blood perfusion detected by Arterial Spin
Labelling MRI in rats

J 2019

Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats

DRAŽANOVÁ, Eva, Jana RUDÁ, Lucie KRÁTKÁ, Tibor ŠTARK, Martin KUCHAŘ et. al.

Základní údaje

Originální název

Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats

Autoři

DRAŽANOVÁ, Eva (203 Česká republika, garant, domácí), Jana RUDÁ (203 Česká republika, domácí), Lucie KRÁTKÁ (203 Česká republika), Tibor ŠTARK (703 Slovensko, domácí), Martin KUCHAŘ (203 Česká republika), Michal MARYŠKA (203 Česká republika), Filippo DRAGO (380 Itálie), Zenon STARČUK (203 Česká republika) a Vincenzo MICALE (380 Itálie)

Vydání

Scientific reports, London, NATURE PUBLISHING GROUP, 2019, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.998

Kód RIV

RIV/00216224:14110/19:00109797

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/s41598-019-42532-z

UT WoS

000464495700010

Klíčová slova anglicky

METHYLAZOXYMETHANOL ACETATE; ANIMAL-MODELS; BRAIN STRUCTURE; CANNABIS USE; SCHIZOPHRENIA; FLOW; METAANALYSIS; SYMPTOMS; DELTA(9)-TETRAHYDROCANNABINOL; DELTA-9-TETRAHYDROCANNABINOL

Štítky

14110516, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 7. 2019 16:53, Soňa Böhmová

Anotace

V originále

Clinical studies consistently report structural impairments (i.e.: ventricular enlargement, decreased volume of anterior cingulate cortex or hippocampus) and functional abnormalities including changes in regional cerebral blood flow in individuals suffering from schizophrenia, which can be evaluated by magnetic resonance imaging (MRI) techniques. The aim of this study was to assess cerebral blood perfusion in several schizophrenia-related brain regions using Arterial Spin Labelling MRI (ASL MRI, 9.4 T Bruker BioSpec 94/30USR scanner) in rats. In this study, prenatal exposure to methylazoxymethanol acetate (MAM, 22 mg/kg) at gestational day (GD) 17 and the perinatal treatment with Delta-9-tetrahydrocannabinol (THC, 5 mg/kg) from GD15 to postnatal day 9 elicited behavioral deficits consistent with schizophrenia-like phenotype, which is in agreement with the neurodevelopmental hypothesis of schizophrenia. In MAM exposed rats a significant enlargement of lateral ventricles and perfusion changes (i.e.: increased blood perfusion in the circle of Willis and sensorimotor cortex and decreased perfusion in hippocampus) were detected. On the other hand, the THC perinatally exposed rats did not show differences in the cerebral blood perfusion in any region of interest. These results suggest that although both pre/perinatal insults showed some of the schizophrenia-like deficits, these are not strictly related to distinct hemodynamic features.

Návaznosti

EF16_013/0001775, projekt VaV

Název: Modernizace a podpora výzkumných aktivit národní infrastruktury pro biologické a medicínské zobrazování Czech-BioImaging

LM2015062, projekt VaV

Název: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, National research infrastructure for biological and medical imaging

MUNI/A/1550/2018, interní kód MU

Název: Farmakologický výzkum v oblasti farmakokinetiky, neuropsychofarmakologie a onkologie

Investor: Masarykova univerzita, Farmakologický výzkum v oblasti farmakokinetiky, neuropsychofarmakologie a onkologie, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

3SGA5789, interní kód MU

Název: PRECIPITATION OF SCHIZOPHRENIA-LIKE PHENOTYPE BY PRENATAL INFLUENCES: ASSESSING THE ROLE OF THE ENDOCANNABINOID SYSTEM (Akronym: ncRNAPain)

Investor: Jihomoravský kraj, PRECIPITATION OF SCHIZOPHRENIA-LIKE PHENOTYPE BY PRENATAL INFLUENCES: ASSESSING THE ROLE OF THE ENDOCANNABINOID SYSTEM, Granty pro zahraniční vědce

Citovat

DRAŽANOVÁ, Eva, Jana RUDÁ, Lucie KRÁTKÁ, Tibor ŠTARK, Martin KUCHAŘ, Michal MARYŠKA, Filippo DRAGO, Zenon STARČUK a Vincenzo MICALE. Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats. Scientific reports. London: NATURE PUBLISHING GROUP, 2019, roč. 9, č. 6062, s. 1-10. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-019-42532-z.

@article{1535701,
   author = {Dražanová, Eva and Rudá, Jana and Krátká, Lucie and Štark, Tibor and Kuchař, Martin and Maryška, Michal and Drago, Filippo and Starčuk, Zenon and Micale, Vincenzo},
   article_location = {London},
   article_number = {6062},
   doi = {http://dx.doi.org/10.1038/s41598-019-42532-z},
   keywords = {METHYLAZOXYMETHANOL ACETATE; ANIMAL-MODELS; BRAIN STRUCTURE; CANNABIS USE; SCHIZOPHRENIA; FLOW; METAANALYSIS; SYMPTOMS; DELTA(9)-TETRAHYDROCANNABINOL; DELTA-9-TETRAHYDROCANNABINOL},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific reports},
   title = {Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats},
   url = {https://www.nature.com/articles/s41598-019-42532-z},
   volume = {9},
   year = {2019}
}

TY  - JOUR
ID  - 1535701
AU  - Dražanová, Eva - Rudá, Jana - Krátká, Lucie - Štark, Tibor - Kuchař, Martin - Maryška, Michal - Drago, Filippo - Starčuk, Zenon - Micale, Vincenzo
PY  - 2019
TI  - Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats
JF  - Scientific reports
VL  - 9
IS  - 6062
SP  - 1-10
EP  - 1-10
PB  - NATURE PUBLISHING GROUP
SN  - 20452322
KW  - METHYLAZOXYMETHANOL ACETATE
KW  - ANIMAL-MODELS
KW  - BRAIN STRUCTURE
KW  - CANNABIS USE
KW  - SCHIZOPHRENIA
KW  - FLOW
KW  - METAANALYSIS
KW  - SYMPTOMS
KW  - DELTA(9)-TETRAHYDROCANNABINOL
KW  - DELTA-9-TETRAHYDROCANNABINOL
UR  - https://www.nature.com/articles/s41598-019-42532-z
L2  - https://www.nature.com/articles/s41598-019-42532-z
N2  - Clinical studies consistently report structural impairments (i.e.: ventricular enlargement, decreased volume of anterior cingulate cortex or hippocampus) and functional abnormalities including changes in regional cerebral blood flow in individuals suffering from schizophrenia, which can be evaluated by magnetic resonance imaging (MRI) techniques. The aim of this study was to assess cerebral blood perfusion in several schizophrenia-related brain regions using Arterial Spin Labelling MRI (ASL MRI, 9.4 T Bruker BioSpec 94/30USR scanner) in rats. In this study, prenatal exposure to methylazoxymethanol acetate (MAM, 22 mg/kg) at gestational day (GD) 17 and the perinatal treatment with Delta-9-tetrahydrocannabinol (THC, 5 mg/kg) from GD15 to postnatal day 9 elicited behavioral deficits consistent with schizophrenia-like phenotype, which is in agreement with the neurodevelopmental hypothesis of schizophrenia. In MAM exposed rats a significant enlargement of lateral ventricles and perfusion changes (i.e.: increased blood perfusion in the circle of Willis and sensorimotor cortex and decreased perfusion in hippocampus) were detected. On the other hand, the THC perinatally exposed rats did not show differences in the cerebral blood perfusion in any region of interest. These results suggest that although both pre/perinatal insults showed some of the schizophrenia-like deficits, these are not strictly related to distinct hemodynamic features.
ER  -

DRAŽANOVÁ, Eva, Jana RUDÁ, Lucie KRÁTKÁ, Tibor ŠTARK, Martin KUCHAŘ, Michal MARYŠKA, Filippo DRAGO, Zenon STARČUK a Vincenzo MICALE. Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats. \textit{Scientific reports}. London: NATURE PUBLISHING GROUP, 2019, roč.~9, č.~6062, s.~1-10. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-019-42532-z.

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