2019
Nematodes as a tool to study insect immunity
HYRŠL, Pavel, Pavel DOBEŠ, Martin KUNC a Jana HURYCHOVÁZákladní údaje
Originální název
Nematodes as a tool to study insect immunity
Název česky
Hlístice jako nástroj pro studium imunity hmyzu
Název anglicky
Nematodes as a tool to study insect immunity
Autoři
HYRŠL, Pavel (203 Česká republika, garant, domácí), Pavel DOBEŠ (203 Česká republika, domácí), Martin KUNC (203 Česká republika, domácí) a Jana HURYCHOVÁ (203 Česká republika, domácí)
Vydání
Frontiers in insect physiology, 2019
Další údaje
Jazyk
čeština
Typ výsledku
Konferenční abstrakt
Obor
40301 Veterinary science
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Kód RIV
RIV/00216224:14310/19:00107461
Organizační jednotka
Přírodovědecká fakulta
Klíčová slova česky
entomoaptogenní hlístice; imunita hmyzu; Heterorhabditis; Steinernema; Galleria; Drosophila
Klíčová slova anglicky
entomopathogenic nematodes; insect immunity; Heterorhabditis; Steinernema; Galleria; Drosophila
Změněno: 17. 6. 2019 11:22, doc. RNDr. Pavel Hyršl, Ph.D.
V originále
Invertebrates and especially insects belong to the ecologically most successful organisms living on Earth. An adaptation to the antigen pressure of the environment (mainly to micro-organisms) depends on insect innate immunity. Invertebrates compensated the absence of complicated immune reactions by specific adaptations and functions of cellular and humoral parts of their immune system. Although an adaptive immunity in the form we know in vertebrates does not exist in invertebrates, there are advanced mechanisms modulating their immune response. Presented studies on fruit fly Drosophila melanogaster, wax moth Galleria mellonella and honey bee Apis mellifera describe cellular and humoral components of their immune system and methods for their measurement. In many experiments we used natural infection model combining two pathogens – bacteria Photorhabdus luminescens and nematode Heterorhabditis bacteriophora with their insect host. New mechanisms of insect immune response to nematobacterial pathogens were identified. Not surprisingly, among the genes significantly affected by the nematobacterial infection, mostly those related to immunity, cellular and developmental processes were found to be crucial, e.g. genes coding for members of coagulation cascade and recognition molecules. This study was supported by grant GAČR 17 - 03253S.
Anglicky
Invertebrates and especially insects belong to the ecologically most successful organisms living on Earth. An adaptation to the antigen pressure of the environment (mainly to micro-organisms) depends on insect innate immunity. Invertebrates compensated the absence of complicated immune reactions by specific adaptations and functions of cellular and humoral parts of their immune system. Although an adaptive immunity in the form we know in vertebrates does not exist in invertebrates, there are advanced mechanisms modulating their immune response. Presented studies on fruit fly Drosophila melanogaster, wax moth Galleria mellonella and honey bee Apis mellifera describe cellular and humoral components of their immune system and methods for their measurement. In many experiments we used natural infection model combining two pathogens – bacteria Photorhabdus luminescens and nematode Heterorhabditis bacteriophora with their insect host. New mechanisms of insect immune response to nematobacterial pathogens were identified. Not surprisingly, among the genes significantly affected by the nematobacterial infection, mostly those related to immunity, cellular and developmental processes were found to be crucial, e.g. genes coding for members of coagulation cascade and recognition molecules. This study was supported by grant GAČR 17 - 03253S.
Návaznosti
| GA17-03253S, projekt VaV |
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