Detailed Information on Publication Record
2019
Nematodes as a tool to study insect immunity
HYRŠL, Pavel, Pavel DOBEŠ, Martin KUNC and Jana HURYCHOVÁBasic information
Original name
Nematodes as a tool to study insect immunity
Name in Czech
Hlístice jako nástroj pro studium imunity hmyzu
Name (in English)
Nematodes as a tool to study insect immunity
Authors
HYRŠL, Pavel (203 Czech Republic, guarantor, belonging to the institution), Pavel DOBEŠ (203 Czech Republic, belonging to the institution), Martin KUNC (203 Czech Republic, belonging to the institution) and Jana HURYCHOVÁ (203 Czech Republic, belonging to the institution)
Edition
Frontiers in insect physiology, 2019
Other information
Language
Czech
Type of outcome
Konferenční abstrakt
Field of Study
40301 Veterinary science
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14310/19:00107461
Organization unit
Faculty of Science
Keywords (in Czech)
entomoaptogenní hlístice; imunita hmyzu; Heterorhabditis; Steinernema; Galleria; Drosophila
Keywords in English
entomopathogenic nematodes; insect immunity; Heterorhabditis; Steinernema; Galleria; Drosophila
Změněno: 17/6/2019 11:22, doc. RNDr. Pavel Hyršl, Ph.D.
V originále
Invertebrates and especially insects belong to the ecologically most successful organisms living on Earth. An adaptation to the antigen pressure of the environment (mainly to micro-organisms) depends on insect innate immunity. Invertebrates compensated the absence of complicated immune reactions by specific adaptations and functions of cellular and humoral parts of their immune system. Although an adaptive immunity in the form we know in vertebrates does not exist in invertebrates, there are advanced mechanisms modulating their immune response. Presented studies on fruit fly Drosophila melanogaster, wax moth Galleria mellonella and honey bee Apis mellifera describe cellular and humoral components of their immune system and methods for their measurement. In many experiments we used natural infection model combining two pathogens – bacteria Photorhabdus luminescens and nematode Heterorhabditis bacteriophora with their insect host. New mechanisms of insect immune response to nematobacterial pathogens were identified. Not surprisingly, among the genes significantly affected by the nematobacterial infection, mostly those related to immunity, cellular and developmental processes were found to be crucial, e.g. genes coding for members of coagulation cascade and recognition molecules. This study was supported by grant GAČR 17 - 03253S.
In English
Invertebrates and especially insects belong to the ecologically most successful organisms living on Earth. An adaptation to the antigen pressure of the environment (mainly to micro-organisms) depends on insect innate immunity. Invertebrates compensated the absence of complicated immune reactions by specific adaptations and functions of cellular and humoral parts of their immune system. Although an adaptive immunity in the form we know in vertebrates does not exist in invertebrates, there are advanced mechanisms modulating their immune response. Presented studies on fruit fly Drosophila melanogaster, wax moth Galleria mellonella and honey bee Apis mellifera describe cellular and humoral components of their immune system and methods for their measurement. In many experiments we used natural infection model combining two pathogens – bacteria Photorhabdus luminescens and nematode Heterorhabditis bacteriophora with their insect host. New mechanisms of insect immune response to nematobacterial pathogens were identified. Not surprisingly, among the genes significantly affected by the nematobacterial infection, mostly those related to immunity, cellular and developmental processes were found to be crucial, e.g. genes coding for members of coagulation cascade and recognition molecules. This study was supported by grant GAČR 17 - 03253S.
Links
| GA17-03253S, research and development project |
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