Impaired Self-Other Distinction and Subcortical Gray-Matter
Alterations Characterize Socio-Cognitive Disturbances in
Multiple Sclerosis

J 2019

Impaired Self-Other Distinction and Subcortical Gray-Matter Alterations Characterize Socio-Cognitive Disturbances in Multiple Sclerosis

CZEKÓOVÁ, Kristína, Daniel Joel SHAW, Kristína SAXUNOVÁ, Michal DUFEK, Radek MAREČEK et. al.

Základní údaje

Originální název

Impaired Self-Other Distinction and Subcortical Gray-Matter Alterations Characterize Socio-Cognitive Disturbances in Multiple Sclerosis

Autoři

CZEKÓOVÁ, Kristína (703 Slovensko, domácí), Daniel Joel SHAW (826 Velká Británie a Severní Irsko, domácí), Kristína SAXUNOVÁ (703 Slovensko, domácí), Michal DUFEK (203 Česká republika, domácí), Radek MAREČEK (203 Česká republika, domácí), Jiří VANÍČEK (203 Česká republika, domácí) a Milan BRÁZDIL (203 Česká republika, garant, domácí)

Vydání

FRONTIERS IN NEUROLOGY, LAUSANNE, FRONTIERS MEDIA SA, 2019, 1664-2295

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.889

Kód RIV

RIV/00216224:14740/19:00107485

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.3389/fneur.2019.00525

UT WoS

000468416300001

Klíčová slova anglicky

multiple sclerosis; social cognition; self-other distinction; automatic imitation; visual perspective taking; voxel-based morphometry; gray-matter volume

Štítky

14110119, 14110127, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 10. 2024 08:42, Ing. Jana Kuchtová

Anotace

V originále

Introduction: Recent studies of patients with multiple sclerosis (MS) have revealed disturbances in distinct components of social cognition, such as impaired mentalizing and empathy. The present study investigated this socio-cognitive profile in MS patients in more detail, by examining their performance on tasks measuring more fundamental components of social cognition and any associated disruptions to gray-matter volume (GMV). Methods: We compared 43 patients with relapse-remitting MS with 43 age- and sex-matched healthy controls (HCs) on clinical characteristics (depression, fatigue), cognitive processing speed, and three aspects of low-level social cognition; specifically, imitative tendencies, visual perspective taking, and emotion recognition. Using voxel-based morphometry, we then explored relationships between GMV and these clinical and behavioral measures. Results: Patients exhibited significantly slower processing speed, poorer perspective taking, and less imitation compared with HCs. These impairments were related to reduced GMV throughout the putamen, thalami, and anterior insula, predominantly in the left hemisphere. Surprisingly, differences between the groups in emotion recognition were not significant. Conclusion: Less imitation and poorer perspective taking indicate a cognitive self-bias when faced with conflicting self-and other-representations. This suggests that impaired self-other distinction, and an associated subcortical pattern of GM atrophy, might underlie the socio-cognitive disturbances observed in MS.

Návaznosti

GA15-16738S, projekt VaV

Název: Individuální rozdíly v diferenciaci mezi reprezentací sebe a druhých lidí

Investor: Grantová agentura ČR, Individuální rozdíly v diferenciaci mezi reprezentací sebe a druhých lidí

90062, velká výzkumná infrastruktura

Název: Czech-BioImaging

Citovat

CZEKÓOVÁ, Kristína, Daniel Joel SHAW, Kristína SAXUNOVÁ, Michal DUFEK, Radek MAREČEK, Jiří VANÍČEK a Milan BRÁZDIL. Impaired Self-Other Distinction and Subcortical Gray-Matter Alterations Characterize Socio-Cognitive Disturbances in Multiple Sclerosis. FRONTIERS IN NEUROLOGY. LAUSANNE: FRONTIERS MEDIA SA, 2019, roč. 10, MAY, s. 525-536. ISSN 1664-2295. Dostupné z: https://dx.doi.org/10.3389/fneur.2019.00525.

@article{1543797,
   author = {Czekóová, Kristína and Shaw, Daniel Joel and Saxunová, Kristína and Dufek, Michal and Mareček, Radek and Vaníček, Jiří and Brázdil, Milan},
   article_location = {LAUSANNE},
   article_number = {MAY},
   doi = {http://dx.doi.org/10.3389/fneur.2019.00525},
   keywords = {multiple sclerosis; social cognition; self-other distinction; automatic imitation; visual perspective taking; voxel-based morphometry; gray-matter volume},
   language = {eng},
   issn = {1664-2295},
   journal = {FRONTIERS IN NEUROLOGY},
   title = {Impaired Self-Other Distinction and Subcortical Gray-Matter Alterations Characterize Socio-Cognitive Disturbances in Multiple Sclerosis},
   url = {https://www.frontiersin.org/articles/10.3389/fneur.2019.00525/full},
   volume = {10},
   year = {2019}
}

TY  - JOUR
ID  - 1543797
AU  - Czekóová, Kristína - Shaw, Daniel Joel - Saxunová, Kristína - Dufek, Michal - Mareček, Radek - Vaníček, Jiří - Brázdil, Milan
PY  - 2019
TI  - Impaired Self-Other Distinction and Subcortical Gray-Matter Alterations Characterize Socio-Cognitive Disturbances in Multiple Sclerosis
JF  - FRONTIERS IN NEUROLOGY
VL  - 10
IS  - MAY
SP  - 525
EP  - 525
PB  - FRONTIERS MEDIA SA
SN  - 16642295
KW  - multiple sclerosis
KW  - social cognition
KW  - self-other distinction
KW  - automatic imitation
KW  - visual perspective taking
KW  - voxel-based morphometry
KW  - gray-matter volume
UR  - https://www.frontiersin.org/articles/10.3389/fneur.2019.00525/full
L2  - https://www.frontiersin.org/articles/10.3389/fneur.2019.00525/full
N2  - Introduction: Recent studies of patients with multiple sclerosis (MS) have revealed disturbances in distinct components of social cognition, such as impaired mentalizing and empathy. The present study investigated this socio-cognitive profile in MS patients in more detail, by examining their performance on tasks measuring more fundamental components of social cognition and any associated disruptions to gray-matter volume (GMV). Methods: We compared 43 patients with relapse-remitting MS with 43 age- and sex-matched healthy controls (HCs) on clinical characteristics (depression, fatigue), cognitive processing speed, and three aspects of low-level social cognition; specifically, imitative tendencies, visual perspective taking, and emotion recognition. Using voxel-based morphometry, we then explored relationships between GMV and these clinical and behavioral measures. Results: Patients exhibited significantly slower processing speed, poorer perspective taking, and less imitation compared with HCs. These impairments were related to reduced GMV throughout the putamen, thalami, and anterior insula, predominantly in the left hemisphere. Surprisingly, differences between the groups in emotion recognition were not significant. Conclusion: Less imitation and poorer perspective taking indicate a cognitive self-bias when faced with conflicting self-and other-representations. This suggests that impaired self-other distinction, and an associated subcortical pattern of GM atrophy, might underlie the socio-cognitive disturbances observed in MS.
ER  -

CZEKÓOVÁ, Kristína, Daniel Joel SHAW, Kristína SAXUNOVÁ, Michal DUFEK, Radek MAREČEK, Jiří VANÍČEK a Milan BRÁZDIL. Impaired Self-Other Distinction and Subcortical Gray-Matter Alterations Characterize Socio-Cognitive Disturbances in Multiple Sclerosis. \textit{FRONTIERS IN NEUROLOGY}. LAUSANNE: FRONTIERS MEDIA SA, 2019, roč.~10, MAY, s.~525-536. ISSN~1664-2295. Dostupné z: https://dx.doi.org/10.3389/fneur.2019.00525.

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