| URÍK, Milan, Pavel HURNIK, Dušan ŽIAK, Josef MACHAČ, Ivo ŠLAPÁK, Oldřich MOTYKA a Petr JABANDŽIEV. Immunohistochemical analysis of retraction pocket pars tensa of tympanic membrane in children. International journal of pediatric otorhinolaryngology. Amsterdam: Elsevier, 2019, roč. 122, JUL 2019, s. 111-116. ISSN 0165-5876. Dostupné z: https://dx.doi.org/10.1016/j.ijporl.2019.04.008. |
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@article{1545096,
author = {Urík, Milan and Hurnik, Pavel and Žiak, Dušan and Machač, Josef and Šlapák, Ivo and Motyka, Oldřich and Jabandžiev, Petr},
article_location = {Amsterdam},
article_number = {JUL 2019},
doi = {http://dx.doi.org/10.1016/j.ijporl.2019.04.008},
keywords = {Retraction pocket; Cholesteatoma; Immunohistochemistry; Chidren; Pars tensa},
language = {eng},
issn = {0165-5876},
journal = {International journal of pediatric otorhinolaryngology},
title = {Immunohistochemical analysis of retraction pocket pars tensa of tympanic membrane in children},
url = {http://dx.doi.org/10.1016/j.ijporl.2019.04.008},
volume = {122},
year = {2019}
}
TY - JOUR
ID - 1545096
AU - Urík, Milan - Hurnik, Pavel - Žiak, Dušan - Machač, Josef - Šlapák, Ivo - Motyka, Oldřich - Jabandžiev, Petr
PY - 2019
TI - Immunohistochemical analysis of retraction pocket pars tensa of tympanic membrane in children
JF - International journal of pediatric otorhinolaryngology
VL - 122
IS - JUL 2019
SP - 111-116
EP - 111-116
PB - Elsevier
SN - 01655876
KW - Retraction pocket
KW - Cholesteatoma
KW - Immunohistochemistry
KW - Chidren
KW - Pars tensa
UR - http://dx.doi.org/10.1016/j.ijporl.2019.04.008
L2 - http://dx.doi.org/10.1016/j.ijporl.2019.04.008
N2 - Aims: Immunohistochemical analysis of retraction pocket pars tensa of tympanic membrane in children. Identification of signs typical for cholesteatoma and support of retraction theory of cholesteatoma. Study design: a prospective study analysing 31 surgically removed retraction pockets. Department: University Hospital, Children's Medical Centre Methods: Retraction pockets processed by a standard process for immunohistochemical analysis. The observed findings were specified using antibodies CD45 LCA (leukocyte common antigen), CD31 (platelet endothelial cell adhesion molecule), D2-40 (marker of lymphatic endothelium), MMP9 (marker of degradation of connective tissue extracellular matrix) and Ki67 (cellular marker of proliferation). Results: All observed parameters except for MMP9 had a significantly higher incidence in retraction pocket stage III compared to stage II according to Charachon. Conclusion: We described immunohistochemical signs of retraction pocket pars tensa of tympanic membrane in children resulting in cholesteatoma. All the observed signs occur in the structure of matrix and perimatrix of cholesteatoma. A significantly higher incidence of all observed parameters except from MMP9 was proved in retraction pocket stage III, unlike in stage II. This observation proves the fact that retraction pocket is a progressive disease and is a procholesteatoma stage.
ER -
URÍK, Milan, Pavel HURNIK, Dušan ŽIAK, Josef MACHAČ, Ivo ŠLAPÁK, Oldřich MOTYKA a Petr JABANDŽIEV. Immunohistochemical analysis of retraction pocket pars tensa of tympanic membrane in children. \textit{International journal of pediatric otorhinolaryngology}. Amsterdam: Elsevier, 2019, roč.~122, JUL 2019, s.~111-116. ISSN~0165-5876. Dostupné z: https://dx.doi.org/10.1016/j.ijporl.2019.04.008.
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