Quantitative Biology of Human Shelterin and Telomerase:
Searching for the Weakest Point

J 2019

Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point

VEVERKA, Pavel; Tomáš JANOVIČ a Ctirad HOFR

Základní údaje

Originální název

Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point

Autoři

VEVERKA, Pavel; Tomáš JANOVIČ a Ctirad HOFR

Vydání

International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2019, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10610 Biophysics

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Full Text

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/19:00107498

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

telomerase; shelterin; telomere; quantitative biology; protein-protein interaction; protein-DNA interaction; assembly; inhibitor; anticancer

Štítky

CF BIC, CF CELLIM, CF PROT, rivok

Příznaky

Recenzováno

Změněno: 6. 5. 2025 14:17, Mgr. Tereza Miškechová

Anotace

V originále

The repetitive telomeric DNA at chromosome ends is protected from unwanted repair by telomere-associated proteins, which form the shelterin complex in mammals. Recent works have provided new insights into the mechanisms of how human shelterin assembles and recruits telomerase to telomeres. Inhibition of telomerase activity and telomerase recruitment to chromosome ends is a promising target for anticancer therapy. Here, we summarize results of quantitative assessments and newly emerged structural information along with the status of the most promising approaches to telomerase inhibition in cancer cells. We focus on the mechanism of shelterin assembly and the mechanisms of how shelterin affects telomerase recruitment to telomeres, addressing the conceptual dilemma of how shelterin allows telomerase action and regulates other essential processes. We evaluate how the identified critical interactions of telomerase and shelterin might be elucidated in future research of new anticancer strategies.

Návaznosti

GA16-20255S, projekt VaV

Název: Molekulární mechanismus inhibice telomerázy: cílené zastavení dělení nádorových buněk

Investor: Grantová agentura ČR, Molekulární mechanismus inhibice telomerázy: cílené zastavení dělení nádorových buněk

GA19-18226S, projekt VaV

Název: Kritické interakce neuronového transkripčního faktoru REST se stabilizátorem TRF2: biofyzikální implikace pro návrh léčiv glioblastomu

Investor: Grantová agentura ČR, Kritické interakce neuronového transkripčního faktoru REST se stabilizátorem TRF2: biofyzikální implikace pro návrh léčiv glioblastomu

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

90043, velká výzkumná infrastruktura

Název: CIISB

90062, velká výzkumná infrastruktura

Název: Czech-BioImaging

Přiložené soubory

Veverka_P_Janovic_T_Hofr_C_2019_ijms-20-03186.pdf

Požádat o autorskou verzi souboru

Citovat

VEVERKA, Pavel; Tomáš JANOVIČ a Ctirad HOFR. Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2019, roč. 20, č. 13, s. 1-13. ISSN 1422-0067. Dostupné z: https://doi.org/10.3390/ijms20133186.

@article{1545296,
   author = {Veverka, Pavel and Janovič, Tomáš and Hofr, Ctirad},
   article_location = {Basel},
   article_number = {13},
   doi = {https://doi.org/10.3390/ijms20133186},
   keywords = {telomerase; shelterin; telomere; quantitative biology; protein-protein interaction; protein-DNA interaction; assembly; inhibitor; anticancer},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point},
   url = {https://doi.org/10.3390/ijms20133186},
   volume = {20},
   year = {2019}
}

TY  - JOUR
ID  - 1545296
AU  - Veverka, Pavel - Janovič, Tomáš - Hofr, Ctirad
PY  - 2019
TI  - Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point
JF  - International Journal of Molecular Sciences
VL  - 20
IS  - 13
SP  - 1-13
EP  - 1-13
PB  - Multidisciplinary Digital Publishing Institute
SN  - 14220067
KW  - telomerase
KW  - shelterin
KW  - telomere
KW  - quantitative biology
KW  - protein-protein interaction
KW  - protein-DNA interaction
KW  - assembly
KW  - inhibitor
KW  - anticancer
UR  - https://doi.org/10.3390/ijms20133186
L2  - https://doi.org/10.3390/ijms20133186
N2  - The repetitive telomeric DNA at chromosome ends is protected from unwanted repair by telomere-associated proteins, which form the shelterin complex in mammals. Recent works have provided new insights into the mechanisms of how human shelterin assembles and recruits telomerase to telomeres. Inhibition of telomerase activity and telomerase recruitment to chromosome ends is a promising target for anticancer therapy. Here, we summarize results of quantitative assessments and newly emerged structural information along with the status of the most promising approaches to telomerase inhibition in cancer cells. We focus on the mechanism of shelterin assembly and the mechanisms of how shelterin affects telomerase recruitment to telomeres, addressing the conceptual dilemma of how shelterin allows telomerase action and regulates other essential processes. We evaluate how the identified critical interactions of telomerase and shelterin might be elucidated in future research of new anticancer strategies.
ER  -

VEVERKA, Pavel; Tomáš JANOVIČ a Ctirad HOFR. Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2019, roč.~20, č.~13, s.~1-13. ISSN~1422-0067. Dostupné z: https://doi.org/10.3390/ijms20133186.

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