Neural Scaffolding as the Foundation for Stable Performance of
Aging Cerebellum

J 2019

Neural Scaffolding as the Foundation for Stable Performance of Aging Cerebellum

FILIP, Pavel, Cécile GALLEA, Stéphane LEHERICY, Ovidiu LUNGU, Martin BAREŠ et. al.

Základní údaje

Originální název

Neural Scaffolding as the Foundation for Stable Performance of Aging Cerebellum

Autoři

FILIP, Pavel (703 Slovensko, garant, domácí), Cécile GALLEA (250 Francie), Stéphane LEHERICY (250 Francie), Ovidiu LUNGU (124 Kanada) a Martin BAREŠ (203 Česká republika, domácí)

Vydání

Cerebellum, New York, Springer, 2019, 1473-4222

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.129

Kód RIV

RIV/00216224:14110/19:00110173

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s12311-019-01015-7

UT WoS

000468112900019

Klíčová slova anglicky

Cerebellar aging; fMRI; Functional connectivity; Voxel-based morphometry

Štítky

14110127, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 7. 2019 13:27, Soňa Böhmová

Anotace

V originále

Although recently conceptualized as a neural node essential for a vast spectrum of associative and cognitive processes, the cerebellum has largely eluded attention in the research of aging, where it is marginalized mainly to structural analyses. In the current cross-sectional study of 67 healthy subjects of various ages (20 to 76 years), we sought to provide a comprehensive, multimodal account of age-related changes in the cerebellum during predictive motor timing, which was previously shown to engage this structure. We combined behavioral assessments of performance with functional MRI and voxel-based morphometry using an advanced method to avoid cerebellar deformation and registration imprecisions inherent to the standard processing at the whole-brain level. Higher age was surprisingly associated with stable behavioral performance during predictive motor timing, despite the massive decrease of infratentorial gray matter volume of a far higher extent than in the supratentorial region, affecting mainly the posterior cerebellar lobe. Nonetheless, this very area showed extensive hyperactivation directly correlated with age. The same region had decreased connectivity with the left caudate and increased connectivity with the left fusiform gyrus, the right pallidum, the hippocampus, and the lingual gyrus. Hence, we propose to extend the scaffolding theory of aging, previously limited mainly to the frontal cortices, to include also the cerebellum, which is likewise suffering from atrophy to a far greater extent than the rest of the brain and is similarly counteracting it by bilateral hyperactivation.

Citovat

FILIP, Pavel, Cécile GALLEA, Stéphane LEHERICY, Ovidiu LUNGU a Martin BAREŠ. Neural Scaffolding as the Foundation for Stable Performance of Aging Cerebellum. Cerebellum. New York: Springer, 2019, roč. 18, č. 3, s. 500-510. ISSN 1473-4222. Dostupné z: https://dx.doi.org/10.1007/s12311-019-01015-7.

@article{1545798,
   author = {Filip, Pavel and Gallea, Cécile and Lehericy, Stéphane and Lungu, Ovidiu and Bareš, Martin},
   article_location = {New York},
   article_number = {3},
   doi = {http://dx.doi.org/10.1007/s12311-019-01015-7},
   keywords = {Cerebellar aging; fMRI; Functional connectivity; Voxel-based morphometry},
   language = {eng},
   issn = {1473-4222},
   journal = {Cerebellum},
   title = {Neural Scaffolding as the Foundation for Stable Performance of Aging Cerebellum},
   url = {http://dx.doi.org/10.1007/s12311-019-01015-7},
   volume = {18},
   year = {2019}
}

TY  - JOUR
ID  - 1545798
AU  - Filip, Pavel - Gallea, Cécile - Lehericy, Stéphane - Lungu, Ovidiu - Bareš, Martin
PY  - 2019
TI  - Neural Scaffolding as the Foundation for Stable Performance of Aging Cerebellum
JF  - Cerebellum
VL  - 18
IS  - 3
SP  - 500-510
EP  - 500-510
PB  - Springer
SN  - 14734222
KW  - Cerebellar aging
KW  - fMRI
KW  - Functional connectivity
KW  - Voxel-based morphometry
UR  - http://dx.doi.org/10.1007/s12311-019-01015-7
L2  - http://dx.doi.org/10.1007/s12311-019-01015-7
N2  - Although recently conceptualized as a neural node essential for a vast spectrum of associative and cognitive processes, the cerebellum has largely eluded attention in the research of aging, where it is marginalized mainly to structural analyses. In the current cross-sectional study of 67 healthy subjects of various ages (20 to 76 years), we sought to provide a comprehensive, multimodal account of age-related changes in the cerebellum during predictive motor timing, which was previously shown to engage this structure. We combined behavioral assessments of performance with functional MRI and voxel-based morphometry using an advanced method to avoid cerebellar deformation and registration imprecisions inherent to the standard processing at the whole-brain level. Higher age was surprisingly associated with stable behavioral performance during predictive motor timing, despite the massive decrease of infratentorial gray matter volume of a far higher extent than in the supratentorial region, affecting mainly the posterior cerebellar lobe. Nonetheless, this very area showed extensive hyperactivation directly correlated with age. The same region had decreased connectivity with the left caudate and increased connectivity with the left fusiform gyrus, the right pallidum, the hippocampus, and the lingual gyrus. Hence, we propose to extend the scaffolding theory of aging, previously limited mainly to the frontal cortices, to include also the cerebellum, which is likewise suffering from atrophy to a far greater extent than the rest of the brain and is similarly counteracting it by bilateral hyperactivation.
ER  -

FILIP, Pavel, Cécile GALLEA, Stéphane LEHERICY, Ovidiu LUNGU a Martin BAREŠ. Neural Scaffolding as the Foundation for Stable Performance of Aging Cerebellum. \textit{Cerebellum}. New York: Springer, 2019, roč.~18, č.~3, s.~500-510. ISSN~1473-4222. Dostupné z: https://dx.doi.org/10.1007/s12311-019-01015-7.

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