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@article{1545802, author = {Vlková, Marcela and Chovancová, Zita and Nechvátalová, Jana and Connelly, Ashley Nicole and Davis, Marcus Darrell and Slanina, Peter and Kučerová, Lucie and Litzman, Marek and Grymová, Tereza and Souček, Přemysl and Freiberger, Tomáš and Litzman, Jiří and Hel, Zdenek}, article_location = {Bethesda}, article_number = {1}, doi = {http://dx.doi.org/10.4049/jimmunol.1800102}, keywords = {Common variable immunodeficiency disorders}, language = {eng}, issn = {0022-1767}, journal = {Journal of immunology}, title = {Neutrophil and Granulocytic Myeloid-Derived Suppressor Cell-Mediated T Cell Suppression Significantly Contributes to Immune Dysregulation in Common Variable Immunodeficiency Disorders}, url = {https://www.jimmunol.org/content/202/1/93}, volume = {202}, year = {2019} }
TY - JOUR ID - 1545802 AU - Vlková, Marcela - Chovancová, Zita - Nechvátalová, Jana - Connelly, Ashley Nicole - Davis, Marcus Darrell - Slanina, Peter - Kučerová, Lucie - Litzman, Marek - Grymová, Tereza - Souček, Přemysl - Freiberger, Tomáš - Litzman, Jiří - Hel, Zdenek PY - 2019 TI - Neutrophil and Granulocytic Myeloid-Derived Suppressor Cell-Mediated T Cell Suppression Significantly Contributes to Immune Dysregulation in Common Variable Immunodeficiency Disorders JF - Journal of immunology VL - 202 IS - 1 SP - 93-104 EP - 93-104 PB - American association of immunologists SN - 00221767 KW - Common variable immunodeficiency disorders UR - https://www.jimmunol.org/content/202/1/93 L2 - https://www.jimmunol.org/content/202/1/93 N2 - Common variable immunodeficiency disorders (CVID) represent a group of primary immunodeficiency diseases characterized by hypogammaglobulinemia and impaired specific Ab response, resulting in recurrent infections due to dysfunctional immune response. The specific mechanisms mediating immune deficiency in CVID remain to be determined. Previous studies indicated that immune dysregulation in CVID patients is associated with chronic microbial translocation, systemic immune activation, and altered homeostasis of lymphocytic and myeloid lineages. A detailed phenotypic, functional characterization of plasma markers and immune cell populations was performed in 46 CVID patients and 44 healthy donors. CVID patients displayed significantly elevated plasma levels of a marker of neutrophil activation neutrophil gelatinase-associated lipocalin. Neutrophils from CVID patients exhibited elevated surface levels of CD11b and PD-L1 and decreased levels of CD62L, CD16, and CD80, consistent with a phenotype of activated neutrophils with suppressive properties. Neutrophils from CVID patients actively suppressed T cell activation and release of IFN-gamma via the production of reactive oxygen species. Furthermore, CVID was associated with an increased frequency of low-density neutrophils (LDNs)/granulocytic myeloid-derived suppressor cells. LDN/granulocytic myeloid-derived suppressor cell frequency in CVID patients correlated with reduced T cell responsiveness. Exogenous stimulation of whole blood with bacterial LPS emulated some but not all of the phenotypic changes observed on neutrophils from CVID patients and induced neutrophil population with LDN phenotype. The presented data demonstrate that neutrophils in the blood of CVID patients acquire an activated phenotype and exert potent T cell suppressive activity. Specific targeting of myeloid cell-derived suppressor activity represents a novel potential therapeutic strategy for CVID. ER -
VLKOVÁ, Marcela, Zita CHOVANCOVÁ, Jana NECHVÁTALOVÁ, Ashley Nicole CONNELLY, Marcus Darrell DAVIS, Peter SLANINA, Lucie KUČEROVÁ, Marek LITZMAN, Tereza GRYMOVÁ, Přemysl SOUČEK, Tomáš FREIBERGER, Jiří LITZMAN a Zdenek HEL. Neutrophil and Granulocytic Myeloid-Derived Suppressor Cell-Mediated T Cell Suppression Significantly Contributes to Immune Dysregulation in Common Variable Immunodeficiency Disorders. \textit{Journal of immunology}. Bethesda: American association of immunologists, 2019, roč.~202, č.~1, s.~93-104. ISSN~0022-1767. Dostupné z: https://dx.doi.org/10.4049/jimmunol.1800102.
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