J 2019

Adipokine gene variability and plasma levels in patients with chronic periodontitis - a case-control study

BOŘILOVÁ LINHARTOVÁ, Petra, Július JÁNOŠ, Hana POSKEROVÁ, Denisa KAVŘÍKOVÁ, Antonín FASSMANN et. al.

Basic information

Original name

Adipokine gene variability and plasma levels in patients with chronic periodontitis - a case-control study

Authors

BOŘILOVÁ LINHARTOVÁ, Petra (203 Czech Republic, belonging to the institution), Július JÁNOŠ (703 Slovakia, belonging to the institution), Hana POSKEROVÁ (203 Czech Republic, belonging to the institution), Denisa KAVŘÍKOVÁ (203 Czech Republic, belonging to the institution), Antonín FASSMANN (203 Czech Republic, belonging to the institution), Ladislav DUŠEK (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

BRAZILIAN ORAL RESEARCH, SAO PAULO, SOCIEDADE BRASILEIRA DE PESQUISA ODONTOLOGICA, 2019, 1807-3107

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30208 Dentistry, oral surgery and medicine

Country of publisher

Brazil

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 1.633

RIV identification code

RIV/00216224:14110/19:00107509

Organization unit

Faculty of Medicine

DOI

UT WoS

000468342300001

Keywords in English

Chronic Periodontitis; Diabetes Mellitus; Type 2; Adipokines

Tags

Tags

International impact, Reviewed
Změněno: 29/4/2020 07:46, Mgr. Tereza Miškechová

Abstract

V originále

Specific variants in genes that encode adipokines and their mRNA and protein expression were previously studied in type 2 diabetes mellitus (T2DM) and obesity, and similar studies have been performed for chronic periodontitis (CP). The aim of this case-control study was to investigate the possible impacts of adiponectin (ADIPOQ), leptin (LEP) and its receptor (LEPR), and resistin (RETN) on the etiopathogenesis of CP. Examinations were performed on 118 non-periodontitis healthy subjects (healthy controls, HC), 205 healthy individuals with CP (H + CP) and 86 type 2 diabetes patients with CP (T2DM + CP). Variants within the ADIPOQ (rs2241766, rs1501299), LEP (rs13228377, rs2167270), LEP receptor (rs1805096), and RETN (rs1862513) genes were determined by qPCR. In addition, the plasma levels of ADIPOQ, LEP, and RETN were analysed by ELISA for 80 individuals. The genotype frequencies of the SNP ADIPOQ + 45G/T (rs2241766) differed between the HC and H + CP groups (p=0.03, p(corr)>0.05), and carriers of the TT genotype had a lower risk of developing CP compared to carriers of the GG or TG genotypes (p<0.01, p(corr)>0.05). However, there were no significant differences in the plasma levels of ADIPOQ, LEP or RETN between the study groups (p > 0.05). Plasma levels of the adipokines were also independent of the gene profiles (p > 0.05). Adipokine plasma levels did not change in patients with H + CP/T2DM + CP compared to HC, but we did identify a specific polymorphism in the ADIPOQ gene that was associated with CP. Although the ADIPOQ + 45G/T (rs2241766) gene variant may be a candidate biomarker for CP, further research is required in larger populations with different ethnic backgrounds before any final conclusions can be drawn about the role of this gene in CP.

Links

GB14-37368G, research and development project
Name: Centrum orofaciálního vývoje a regenerace
Investor: Czech Science Foundation
MUNI/A/1008/2017, interní kód MU
Name: Etiopatogenetické aspekty, diagnostika a léčba vybraných onemocnění dutiny ústní
Investor: Masaryk University, Category A
MUNI/A/1546/2018, interní kód MU
Name: Etiopatogeneze, diagnostika a léčba vybraných onemocnění dutiny ústní a jejich souvislost s celkovým zdravotním stavem
Investor: Masaryk University, Category A
ROZV/25/LF/2017, interní kód MU
Name: LF - Příspěvek na IP 2017
Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects