Retinal photoreceptor apoptosis is associated with impaired
serum ionized calcium homeostasis in diabetic retinopathy: An
in-vivo analysis

J 2019

Retinal photoreceptor apoptosis is associated with impaired serum ionized calcium homeostasis in diabetic retinopathy: An in-vivo analysis

ANKITA, A., Sandeep SAXENA, Dwividendra K. NIM, Jana STEFANICKOVA, Peter ZIAK et. al.

Základní údaje

Originální název

Retinal photoreceptor apoptosis is associated with impaired serum ionized calcium homeostasis in diabetic retinopathy: An in-vivo analysis

Autoři

ANKITA, A. (356 Indie), Sandeep SAXENA (356 Indie), Dwividendra K. NIM (356 Indie), Jana STEFANICKOVA (703 Slovensko), Peter ZIAK (703 Slovensko), Patrik STEFANICKA (703 Slovensko) a Peter KRUŽLIAK (703 Slovensko, garant, domácí)

Vydání

Journal of Diabetes and its Complications, New York, Elsevier Science Inc. 2019, 1056-8727

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30202 Endocrinology and metabolism

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.781

Kód RIV

RIV/00216224:14110/19:00110191

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.jdiacomp.2018.12.003

UT WoS

000459522300006

Klíčová slova anglicky

Diabetic retinopathy; Ionized calcium; Spectral-domain optical coherence tomography; Retinal photoreceptor apoptosis; Autophagy; Ellipsoid zone

Štítky

14110121, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 7. 2019 15:50, Soňa Böhmová

Anotace

V originále

Purpose: The aim of this work was to study the association of serum ionized calcium with retinal photoreceptor apoptosis on spectral domain optical coherence tomography (SD-OCT) in diabetic retinopathy (DR). Methods: Sixty consecutive cases with Type 2 diabetes mellitus were categorized into three groups: no diabetic retinopathy; non-proliferative DR; proliferative DR. The eye with more severe form of the disease was considered. Twenty healthy controls were also included. Best corrected visual acuity (BCVA) was measured on logMAR scale. Retinal photoreceptor apoptosis was defined as disruption of retinal photoreceptor ellipsoid zone (EZ). Ellipsoid zone disruption was assessed using SD-OCT. Serum levels of total and ionized calcium were measured using standard protocol. Results: EZ disruption was found to be positively associated with serum total calcium and ionized calcium. Also, EZ disruption was found to be positively associated with logMAR BCVA. Conclusion: Increased serum ionized calcium induces retinal photoreceptor apoptosis resulting in increased EZ disruption in DR.

Citovat

ANKITA, A., Sandeep SAXENA, Dwividendra K. NIM, Jana STEFANICKOVA, Peter ZIAK, Patrik STEFANICKA a Peter KRUŽLIAK. Retinal photoreceptor apoptosis is associated with impaired serum ionized calcium homeostasis in diabetic retinopathy: An in-vivo analysis. Journal of Diabetes and its Complications. New York: Elsevier Science Inc., 2019, roč. 33, č. 3, s. 208-211. ISSN 1056-8727. Dostupné z: https://dx.doi.org/10.1016/j.jdiacomp.2018.12.003.

@article{1545965,
   author = {Ankita, A. and Saxena, Sandeep and Nim, Dwividendra K. and Stefanickova, Jana and Ziak, Peter and Stefanicka, Patrik and Kružliak, Peter},
   article_location = {New York},
   article_number = {3},
   doi = {http://dx.doi.org/10.1016/j.jdiacomp.2018.12.003},
   keywords = {Diabetic retinopathy; Ionized calcium; Spectral-domain optical coherence tomography; Retinal photoreceptor apoptosis; Autophagy; Ellipsoid zone},
   language = {eng},
   issn = {1056-8727},
   journal = {Journal of Diabetes and its Complications},
   title = {Retinal photoreceptor apoptosis is associated with impaired serum ionized calcium homeostasis in diabetic retinopathy: An in-vivo analysis},
   url = {http://dx.doi.org/10.1016/j.jdiacomp.2018.12.003},
   volume = {33},
   year = {2019}
}

TY  - JOUR
ID  - 1545965
AU  - Ankita, A. - Saxena, Sandeep - Nim, Dwividendra K. - Stefanickova, Jana - Ziak, Peter - Stefanicka, Patrik - Kružliak, Peter
PY  - 2019
TI  - Retinal photoreceptor apoptosis is associated with impaired serum ionized calcium homeostasis in diabetic retinopathy: An in-vivo analysis
JF  - Journal of Diabetes and its Complications
VL  - 33
IS  - 3
SP  - 208-211
EP  - 208-211
PB  - Elsevier Science Inc.
SN  - 10568727
KW  - Diabetic retinopathy
KW  - Ionized calcium
KW  - Spectral-domain optical coherence tomography
KW  - Retinal photoreceptor apoptosis
KW  - Autophagy
KW  - Ellipsoid zone
UR  - http://dx.doi.org/10.1016/j.jdiacomp.2018.12.003
L2  - http://dx.doi.org/10.1016/j.jdiacomp.2018.12.003
N2  - Purpose: The aim of this work was to study the association of serum ionized calcium with retinal photoreceptor apoptosis on spectral domain optical coherence tomography (SD-OCT) in diabetic retinopathy (DR). Methods: Sixty consecutive cases with Type 2 diabetes mellitus were categorized into three groups: no diabetic retinopathy; non-proliferative DR; proliferative DR. The eye with more severe form of the disease was considered. Twenty healthy controls were also included. Best corrected visual acuity (BCVA) was measured on logMAR scale. Retinal photoreceptor apoptosis was defined as disruption of retinal photoreceptor ellipsoid zone (EZ). Ellipsoid zone disruption was assessed using SD-OCT. Serum levels of total and ionized calcium were measured using standard protocol. Results: EZ disruption was found to be positively associated with serum total calcium and ionized calcium. Also, EZ disruption was found to be positively associated with logMAR BCVA. Conclusion: Increased serum ionized calcium induces retinal photoreceptor apoptosis resulting in increased EZ disruption in DR.
ER  -

ANKITA, A., Sandeep SAXENA, Dwividendra K. NIM, Jana STEFANICKOVA, Peter ZIAK, Patrik STEFANICKA a Peter KRUŽLIAK. Retinal photoreceptor apoptosis is associated with impaired serum ionized calcium homeostasis in diabetic retinopathy: An in-vivo analysis. \textit{Journal of Diabetes and its Complications}. New York: Elsevier Science Inc., 2019, roč.~33, č.~3, s.~208-211. ISSN~1056-8727. Dostupné z: https://dx.doi.org/10.1016/j.jdiacomp.2018.12.003.

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