Common Metabolic Pathways Implicated in Resistance to
Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer

J 2019

Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer

ABAD, Etna, Yoelsis GARCIA-MAYEA, Cristina MIR, David SEBASTIAN, Antonio ZORZANO et. al.

Základní údaje

Originální název

Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer

Autoři

ABAD, Etna (724 Španělsko), Yoelsis GARCIA-MAYEA (724 Španělsko), Cristina MIR (724 Španělsko), David SEBASTIAN (724 Španělsko), Antonio ZORZANO (724 Španělsko), David POTĚŠIL (203 Česká republika, domácí), Zbyněk ZDRÁHAL (203 Česká republika, garant, domácí), Alex LYAKHOVICH (724 Španělsko) a Matilde LLEONART (724 Španělsko)

Vydání

Molecular and Cellurar Proteomic, American Society for Biochemistry and Molecular Biology, 2019, 1535-9476

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.870

Kód RIV

RIV/00216224:14740/19:00107512

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1074/mcp.RA118.001102

UT WoS

000457454000005

Klíčová slova anglicky

STEM-CELLS; DYSFUNCTION; AUTOPHAGY; HYDROXYCHLOROQUINE; TOXICITY; TARGET; GROWTH; ACID

Štítky

CF PROT, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 11. 2024 20:19, Ing. Martina Blahová

Anotace

V originále

Cancer cells are known to reprogram their metabolism to adapt to adverse conditions dictated by tumor growth and microenvironment. A subtype of cancer cells with stem-like properties, known as cancer stem cells (CSC), is thought to be responsible for tumor recurrence. In this study, we demonstrated that CSC and chemoresistant cells derived from triple negative breast cancer cells display an enrichment of up-and downregulated proteins from metabolic pathways that suggests their dependence on mitochondria for survival. Here, we selected antibiotics, in particular - linezolid, inhibiting translation of mitoribosomes and inducing mitochondrial dysfunction. We provided the first in vivo evidence demonstrating that linezolid suppressed tumor growth rate, accompanied by increased autophagy. In addition, our results revealed that bactericidal antibiotics used in combination with autophagy blocker decrease tumor growth. This study puts mitochondria in a spotlight for cancer therapy and places antibiotics as effective agents for eliminating CSC and resistant cells.

Návaznosti

GBP206/12/G151, projekt VaV

Název: Centrum nových přístupů k bioanalýze a molekulární diagnostice

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

90043, velká výzkumná infrastruktura

Název: CIISB

Citovat

ABAD, Etna, Yoelsis GARCIA-MAYEA, Cristina MIR, David SEBASTIAN, Antonio ZORZANO, David POTĚŠIL, Zbyněk ZDRÁHAL, Alex LYAKHOVICH a Matilde LLEONART. Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer. Molecular and Cellurar Proteomic. American Society for Biochemistry and Molecular Biology, 2019, roč. 18, č. 2, s. 231-244. ISSN 1535-9476. Dostupné z: https://dx.doi.org/10.1074/mcp.RA118.001102.

@article{1545967,
   author = {Abad, Etna and GarciaandMayea, Yoelsis and Mir, Cristina and Sebastian, David and Zorzano, Antonio and Potěšil, David and Zdráhal, Zbyněk and Lyakhovich, Alex and Lleonart, Matilde},
   article_number = {2},
   doi = {http://dx.doi.org/10.1074/mcp.RA118.001102},
   keywords = {STEM-CELLS; DYSFUNCTION; AUTOPHAGY; HYDROXYCHLOROQUINE; TOXICITY; TARGET; GROWTH; ACID},
   language = {eng},
   issn = {1535-9476},
   journal = {Molecular and Cellurar Proteomic},
   title = {Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer},
   url = {https://www.mcponline.org/content/18/2/231},
   volume = {18},
   year = {2019}
}

TY  - JOUR
ID  - 1545967
AU  - Abad, Etna - Garcia-Mayea, Yoelsis - Mir, Cristina - Sebastian, David - Zorzano, Antonio - Potěšil, David - Zdráhal, Zbyněk - Lyakhovich, Alex - Lleonart, Matilde
PY  - 2019
TI  - Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer
JF  - Molecular and Cellurar Proteomic
VL  - 18
IS  - 2
SP  - 231-244
EP  - 231-244
PB  - American Society for Biochemistry and Molecular Biology
SN  - 15359476
KW  - STEM-CELLS
KW  - DYSFUNCTION
KW  - AUTOPHAGY
KW  - HYDROXYCHLOROQUINE
KW  - TOXICITY
KW  - TARGET
KW  - GROWTH
KW  - ACID
UR  - https://www.mcponline.org/content/18/2/231
L2  - https://www.mcponline.org/content/18/2/231
N2  - Cancer cells are known to reprogram their metabolism to adapt to adverse conditions dictated by tumor growth and microenvironment. A subtype of cancer cells with stem-like properties, known as cancer stem cells (CSC), is thought to be responsible for tumor recurrence. In this study, we demonstrated that CSC and chemoresistant cells derived from triple negative breast cancer cells display an enrichment of up-and downregulated proteins from metabolic pathways that suggests their dependence on mitochondria for survival. Here, we selected antibiotics, in particular - linezolid, inhibiting translation of mitoribosomes and inducing mitochondrial dysfunction. We provided the first in vivo evidence demonstrating that linezolid suppressed tumor growth rate, accompanied by increased autophagy. In addition, our results revealed that bactericidal antibiotics used in combination with autophagy blocker decrease tumor growth. This study puts mitochondria in a spotlight for cancer therapy and places antibiotics as effective agents for eliminating CSC and resistant cells.
ER  -

ABAD, Etna, Yoelsis GARCIA-MAYEA, Cristina MIR, David SEBASTIAN, Antonio ZORZANO, David POTĚŠIL, Zbyněk ZDRÁHAL, Alex LYAKHOVICH a Matilde LLEONART. Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer. \textit{Molecular and Cellurar Proteomic}. American Society for Biochemistry and Molecular Biology, 2019, roč.~18, č.~2, s.~231-244. ISSN~1535-9476. Dostupné z: https://dx.doi.org/10.1074/mcp.RA118.001102.

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