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@article{1545967,
author = {Abad, Etna and GarciaandMayea, Yoelsis and Mir, Cristina and Sebastian, David and Zorzano, Antonio and Potěšil, David and Zdráhal, Zbyněk and Lyakhovich, Alex and Lleonart, Matilde},
article_number = {2},
doi = {http://dx.doi.org/10.1074/mcp.RA118.001102},
keywords = {STEM-CELLS; DYSFUNCTION; AUTOPHAGY; HYDROXYCHLOROQUINE; TOXICITY; TARGET; GROWTH; ACID},
language = {eng},
issn = {1535-9476},
journal = {Molecular and Cellurar Proteomic},
title = {Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer},
url = {https://www.mcponline.org/content/18/2/231},
volume = {18},
year = {2019}
}
TY - JOUR
ID - 1545967
AU - Abad, Etna - Garcia-Mayea, Yoelsis - Mir, Cristina - Sebastian, David - Zorzano, Antonio - Potěšil, David - Zdráhal, Zbyněk - Lyakhovich, Alex - Lleonart, Matilde
PY - 2019
TI - Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer
JF - Molecular and Cellurar Proteomic
VL - 18
IS - 2
SP - 231-244
EP - 231-244
PB - American Society for Biochemistry and Molecular Biology
SN - 15359476
KW - STEM-CELLS
KW - DYSFUNCTION
KW - AUTOPHAGY
KW - HYDROXYCHLOROQUINE
KW - TOXICITY
KW - TARGET
KW - GROWTH
KW - ACID
UR - https://www.mcponline.org/content/18/2/231
L2 - https://www.mcponline.org/content/18/2/231
N2 - Cancer cells are known to reprogram their metabolism to adapt to adverse conditions dictated by tumor growth and microenvironment. A subtype of cancer cells with stem-like properties, known as cancer stem cells (CSC), is thought to be responsible for tumor recurrence. In this study, we demonstrated that CSC and chemoresistant cells derived from triple negative breast cancer cells display an enrichment of up-and downregulated proteins from metabolic pathways that suggests their dependence on mitochondria for survival. Here, we selected antibiotics, in particular - linezolid, inhibiting translation of mitoribosomes and inducing mitochondrial dysfunction. We provided the first in vivo evidence demonstrating that linezolid suppressed tumor growth rate, accompanied by increased autophagy. In addition, our results revealed that bactericidal antibiotics used in combination with autophagy blocker decrease tumor growth. This study puts mitochondria in a spotlight for cancer therapy and places antibiotics as effective agents for eliminating CSC and resistant cells.
ER -
ABAD, Etna, Yoelsis GARCIA-MAYEA, Cristina MIR, David SEBASTIAN, Antonio ZORZANO, David POTĚŠIL, Zbyněk ZDRÁHAL, Alex LYAKHOVICH and Matilde LLEONART. Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer. \textit{Molecular and Cellurar Proteomic}. American Society for Biochemistry and Molecular Biology, 2019, vol.~18, No~2, p.~231-244. ISSN~1535-9476. Available from: https://dx.doi.org/10.1074/mcp.RA118.001102.
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