The role of dietary phytochemicals in the carcinogenesis via
the modulation of miRNA expression

J 2019

The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression

SAMEC, Marek, Alena LISKOVA, Peter KUBATKA, Sona URAMOVA, Pavol ZUBOR et. al.

Základní údaje

Originální název

The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression

Autoři

SAMEC, Marek (703 Slovensko), Alena LISKOVA (703 Slovensko), Peter KUBATKA (703 Slovensko), Sona URAMOVA (703 Slovensko), Pavol ZUBOR (703 Slovensko), Samson Mathews SAMUEL (634 Katar), Anthony ZULLI (36 Austrálie), Martin PEC (703 Slovensko), Tibor BIELIK (703 Slovensko), Kamil BIRINGER (703 Slovensko), Erik KUDELA (703 Slovensko), Jozef BENACKA (703 Slovensko), Mariusz ADAMEK (616 Polsko), Luis RODRIGO (724 Španělsko), Rachele CICCOCIOPPO (380 Itálie), Taeg Kyu KWON (410 Korejská republika), Denis BARANENKO (643 Rusko), Peter KRUŽLIAK (703 Slovensko, garant, domácí) a Daniel BUSSELBERG (705 Slovinsko)

Vydání

Journal of cancer research and clinical oncology, Germany, Springer-Verlag, 2019, 0171-5216

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.656

Kód RIV

RIV/00216224:14110/19:00110196

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s00432-019-02940-0

UT WoS

000471645800001

Klíčová slova anglicky

microRNAs; Phytochemicals; Plant-derived food; Cancer; Carcinogenesis

Štítky

14110121, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 7. 2019 16:38, Soňa Böhmová

Anotace

V originále

PurposePhytochemicals are naturally occurring plant-derived compounds and some of them have the potential to serve as anticancer drugs. Based on recent evidence, aberrantly regulated expression of microRNAs (miRNAs) is closely associated with malignancy. MicroRNAs are characterized as small non-coding RNAs functioning as posttranscriptional regulators of gene expression. Accordingly, miRNAs regulate various target genes, some of which are involved in the process of carcinogenesis.ResultsThis comprehensive review emphasizes the anticancer potential of phytochemicals, either isolated or in combination, mediated by miRNAs. The ability to modulate the expression of miRNAs demonstrates their importance as regulators of tumorigenesis. Phytochemicals as anticancer agents targeting miRNAs are widely studied in preclinical in vitro and in vivo research. Unfortunately, their anticancer efficacy in targeting miRNAs is less investigated in clinical research.ConclusionsSignificant anticancer properties of phytochemicals as regulators of miRNA expression have been proven, but more studies investigating their clinical relevance are needed.

Citovat

SAMEC, Marek, Alena LISKOVA, Peter KUBATKA, Sona URAMOVA, Pavol ZUBOR, Samson Mathews SAMUEL, Anthony ZULLI, Martin PEC, Tibor BIELIK, Kamil BIRINGER, Erik KUDELA, Jozef BENACKA, Mariusz ADAMEK, Luis RODRIGO, Rachele CICCOCIOPPO, Taeg Kyu KWON, Denis BARANENKO, Peter KRUŽLIAK a Daniel BUSSELBERG. The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression. Journal of cancer research and clinical oncology. Germany: Springer-Verlag, 2019, roč. 145, č. 7, s. 1665-1679. ISSN 0171-5216. Dostupné z: https://dx.doi.org/10.1007/s00432-019-02940-0.

@article{1545977,
   author = {Samec, Marek and Liskova, Alena and Kubatka, Peter and Uramova, Sona and Zubor, Pavol and Samuel, Samson Mathews and Zulli, Anthony and Pec, Martin and Bielik, Tibor and Biringer, Kamil and Kudela, Erik and Benacka, Jozef and Adamek, Mariusz and Rodrigo, Luis and Ciccocioppo, Rachele and Kwon, Taeg Kyu and Baranenko, Denis and Kružliak, Peter and Busselberg, Daniel},
   article_location = {Germany},
   article_number = {7},
   doi = {http://dx.doi.org/10.1007/s00432-019-02940-0},
   keywords = {microRNAs; Phytochemicals; Plant-derived food; Cancer; Carcinogenesis},
   language = {eng},
   issn = {0171-5216},
   journal = {Journal of cancer research and clinical oncology},
   title = {The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression},
   url = {http://dx.doi.org/10.1007/s00432-019-02940-0},
   volume = {145},
   year = {2019}
}

TY  - JOUR
ID  - 1545977
AU  - Samec, Marek - Liskova, Alena - Kubatka, Peter - Uramova, Sona - Zubor, Pavol - Samuel, Samson Mathews - Zulli, Anthony - Pec, Martin - Bielik, Tibor - Biringer, Kamil - Kudela, Erik - Benacka, Jozef - Adamek, Mariusz - Rodrigo, Luis - Ciccocioppo, Rachele - Kwon, Taeg Kyu - Baranenko, Denis - Kružliak, Peter - Busselberg, Daniel
PY  - 2019
TI  - The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression
JF  - Journal of cancer research and clinical oncology
VL  - 145
IS  - 7
SP  - 1665-1679
EP  - 1665-1679
PB  - Springer-Verlag
SN  - 01715216
KW  - microRNAs
KW  - Phytochemicals
KW  - Plant-derived food
KW  - Cancer
KW  - Carcinogenesis
UR  - http://dx.doi.org/10.1007/s00432-019-02940-0
L2  - http://dx.doi.org/10.1007/s00432-019-02940-0
N2  - PurposePhytochemicals are naturally occurring plant-derived compounds and some of them have the potential to serve as anticancer drugs. Based on recent evidence, aberrantly regulated expression of microRNAs (miRNAs) is closely associated with malignancy. MicroRNAs are characterized as small non-coding RNAs functioning as posttranscriptional regulators of gene expression. Accordingly, miRNAs regulate various target genes, some of which are involved in the process of carcinogenesis.ResultsThis comprehensive review emphasizes the anticancer potential of phytochemicals, either isolated or in combination, mediated by miRNAs. The ability to modulate the expression of miRNAs demonstrates their importance as regulators of tumorigenesis. Phytochemicals as anticancer agents targeting miRNAs are widely studied in preclinical in vitro and in vivo research. Unfortunately, their anticancer efficacy in targeting miRNAs is less investigated in clinical research.ConclusionsSignificant anticancer properties of phytochemicals as regulators of miRNA expression have been proven, but more studies investigating their clinical relevance are needed.
ER  -

SAMEC, Marek, Alena LISKOVA, Peter KUBATKA, Sona URAMOVA, Pavol ZUBOR, Samson Mathews SAMUEL, Anthony ZULLI, Martin PEC, Tibor BIELIK, Kamil BIRINGER, Erik KUDELA, Jozef BENACKA, Mariusz ADAMEK, Luis RODRIGO, Rachele CICCOCIOPPO, Taeg Kyu KWON, Denis BARANENKO, Peter KRUŽLIAK a Daniel BUSSELBERG. The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression. \textit{Journal of cancer research and clinical oncology}. Germany: Springer-Verlag, 2019, roč.~145, č.~7, s.~1665-1679. ISSN~0171-5216. Dostupné z: https://dx.doi.org/10.1007/s00432-019-02940-0.

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