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@article{1546080,
author = {Dobrotková, Viera and Chlapek, Petr and Ježová, Marta and Adámková, Kateřina and Mazánek, Pavel and Štěrba, Jaroslav and Veselská, Renata},
article_location = {San Francisco},
article_number = {6},
doi = {http://dx.doi.org/10.1371/journal.pone.0218269},
keywords = {Neuroblastoma; induced differentiation; retinoids; retinoic acid; bexarotene; fenretinide; biomarkers},
language = {eng},
issn = {1932-6203},
journal = {PLOS ONE},
title = {Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers},
url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218269},
volume = {14},
year = {2019}
}
TY - JOUR
ID - 1546080
AU - Dobrotková, Viera - Chlapek, Petr - Ježová, Marta - Adámková, Kateřina - Mazánek, Pavel - Štěrba, Jaroslav - Veselská, Renata
PY - 2019
TI - Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers
JF - PLOS ONE
VL - 14
IS - 6
SP - 1-18
EP - 1-18
PB - Public Library of Science
SN - 19326203
KW - Neuroblastoma
KW - induced differentiation
KW - retinoids
KW - retinoic acid
KW - bexarotene
KW - fenretinide
KW - biomarkers
UR - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218269
L2 - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218269
N2 - Although the administration of retinoids represents an important part of treatment for children suffering from high-risk neuroblastomas, approximately 50% of these patients do not respond to this therapy or develop resistance to retinoids during treatment. Our study focused on the comparative analysis of the expression of five genes and corresponding proteins (DDX39A, HMGA1, HMGA2, HOXC9 and PBX1) that have recently been discussed as possible predictive biomarkers of clinical response to retinoid differentiation therapy. Expression of these five candidate biomarkers was evaluated at both the mRNA and protein level in the same subset of 8 neuroblastoma cell lines after treatment with natural or synthetic retinoids. We found that the cell lines that were HMGA2-positive and/or HOXC9-negative have a reduced sensitivity to retinoids. Furthermore, the experiments revealed that the retinoid-sensitive cell lines showed a uniform pattern of change after treatment with both natural and sensitive retinoids: increased DDX39A and decreased PBX1 protein levels. Our results showed that in NBL cells, these putative protein biomarkers are associated with sensitivity or resistance to retinoids, and their endogenous or induced expression can distinguish between these two phenotypes.
ER -
DOBROTKOVÁ, Viera, Petr CHLAPEK, Marta JEŽOVÁ, Kateřina ADÁMKOVÁ, Pavel MAZÁNEK, Jaroslav ŠTĚRBA and Renata VESELSKÁ. Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers. \textit{PLOS ONE}. San Francisco: Public Library of Science, 2019, vol.~14, No~6, p.~1-18. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0218269.
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