| SOJKA, Martin, Michaela FOJTŮ, Jindřiška FIALOVÁ, Michal MASAŘÍK, Marek NEČAS and Radek MAREK. Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties. Inorganic Chemistry. American Chemical Society, 2019, vol. 58, No 16, p. 10861-10870, 12 pp. ISSN 0020-1669. Available from: https://dx.doi.org/10.1021/acs.inorgchem.9b01203. |
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@article{1547498,
author = {Sojka, Martin and Fojtů, Michaela and Fialová, Jindřiška and Masařík, Michal and Nečas, Marek and Marek, Radek},
article_number = {16},
doi = {http://dx.doi.org/10.1021/acs.inorgchem.9b01203},
keywords = {metallodrug;ruthenium;rotaxane;cucurbituril;anticancer;antimetastatic},
language = {eng},
issn = {0020-1669},
journal = {Inorganic Chemistry},
title = {Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties},
url = {http://dx.doi.org/10.1021/acs.inorgchem.9b01203},
volume = {58},
year = {2019}
}
TY - JOUR
ID - 1547498
AU - Sojka, Martin - Fojtů, Michaela - Fialová, Jindřiška - Masařík, Michal - Nečas, Marek - Marek, Radek
PY - 2019
TI - Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties
JF - Inorganic Chemistry
VL - 58
IS - 16
SP - 10861-10870
EP - 10861-10870
PB - American Chemical Society
SN - 00201669
KW - metallodrug;ruthenium;rotaxane;cucurbituril;anticancer;antimetastatic
UR - http://dx.doi.org/10.1021/acs.inorgchem.9b01203
L2 - http://dx.doi.org/10.1021/acs.inorgchem.9b01203
N2 - We report here the first coupling of Ru(II) units with cucurbit[6/7]uril-based pseudorotaxane ligands meant for biological application. The resulting ruthenium-capped rotaxanes were fully characterized, and a structure of one supramolecular system was determined by X-ray diffraction. Because the biological properties of Ru-based metallodrugs are tightly linked to the ligand-exchange processes, the effect of salt concentration on the hydrolysis of chlorides from the Ru(II) center was monitored by using 1H NMR spectroscopy. The biological activity of Ru(II)-based rotaxanes was evaluated for three selected mammalian breast cell lines, HBL-100, MCF-7, and MDA-MB-231. The antimetastatic activity of the assembled cationic Ru(II)-rotaxane systems, evaluated in migration assays against MCF-7 and MDA-MB-231 cell lines, is notably enhanced compared to that of RAPTA-C, a reference that was used. The indicated synergistic effect of combining Ru(II) with a pseudorotaxane unit opens a new direction in searching for anticancer supramolecular metallodrugs.
ER -
SOJKA, Martin, Michaela FOJTŮ, Jindřiška FIALOVÁ, Michal MASAŘÍK, Marek NEČAS and Radek MAREK. Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties. \textit{Inorganic Chemistry}. American Chemical Society, 2019, vol.~58, No~16, p.~10861-10870, 12 pp. ISSN~0020-1669. Available from: https://dx.doi.org/10.1021/acs.inorgchem.9b01203.
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