Early-life exposure to household chemicals and wheezing in
children

J 2019

Early-life exposure to household chemicals and wheezing in children

MIKEŠ, Ondřej, Markéta VRBOVÁ, Jana KLÁNOVÁ, Pavel ČUPR, Jan ŠVANCARA et. al.

Základní údaje

Originální název

Early-life exposure to household chemicals and wheezing in children

Autoři

MIKEŠ, Ondřej (203 Česká republika, domácí), Markéta VRBOVÁ (203 Česká republika, domácí), Jana KLÁNOVÁ (203 Česká republika, domácí), Pavel ČUPR (203 Česká republika, domácí), Jan ŠVANCARA (203 Česká republika, domácí) a Hynek PIKHART (203 Česká republika, garant, domácí)

Vydání

Science of the Total Environment, Amsterdam, Elsevier Science, 2019, 0048-9697

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.551

Kód RIV

RIV/00216224:14310/19:00110312

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.scitotenv.2019.01.254

UT WoS

000459858500041

Klíčová slova anglicky

Wheezing; Household chemicals; Asthma; ELSPAC; Cohort; Children; Indoor

Štítky

14110114, 14110213, 14119612, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 22. 5. 2020 12:14, Mgr. Marie Šípková, DiS.

Anotace

V originále

The prevalence of the asthmatic symptoms among children increases globally over the time. Reduced exposure to pathogens in early childhood and increased exposure to anthropogenic irritants result in increased risk of wheezing in children, and all of this may be related to the usage of household chemicals. Objective of this analysis thus was to study the potential effects of overall exposure to home chemicals in the early life on the phenotypes of wheezing from birth until five years of age. 3411 mother-infant pairs from the Czech part of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC-CZ) participated in the study. The exposure was estimated by the composite household chemical score from 18 chemical-based products. Social, medical and environmental factors were taken into account as covariates in multivariable multinomial logistic regression using phenotypes of wheezing as a study outcome. We were able to determine the association between several wheezing childhood phenotypes and the frequent usage of household chemicals in the fully adjusted model. Statistically significant odds ratios (OR) for increasing exposures per 1 SD of exposure score were obtained for the intermediate onset transient (OR 1.27, 95% CI 1.10-1.47), intermediated onset persistent (OR 1.23, 95% CI 1.03-1.46), and early onset persistent phenotypes (OR 1.36, 95% CI 1.04-1.77) in comparison to never wheezing children. Moreover, the persistent phenotypes were significantly associated with school age asthma. Our study negative role of the increased household chemicals usage on the respiratory outcomes in children up to five years of age. Overall evaluation of the household chemical exposure may be useful tool for any large epidemiological studies.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

EF16_013/0001761, projekt VaV

Název: RECETOX RI

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

MIKEŠ, Ondřej, Markéta VRBOVÁ, Jana KLÁNOVÁ, Pavel ČUPR, Jan ŠVANCARA a Hynek PIKHART. Early-life exposure to household chemicals and wheezing in children. Science of the Total Environment. Amsterdam: Elsevier Science, 2019, roč. 663, May, s. 418-425. ISSN 0048-9697. Dostupné z: https://dx.doi.org/10.1016/j.scitotenv.2019.01.254.

@article{1548477,
   author = {Mikeš, Ondřej and Vrbová, Markéta and Klánová, Jana and Čupr, Pavel and Švancara, Jan and Pikhart, Hynek},
   article_location = {Amsterdam},
   article_number = {May},
   doi = {http://dx.doi.org/10.1016/j.scitotenv.2019.01.254},
   keywords = {Wheezing; Household chemicals; Asthma; ELSPAC; Cohort; Children; Indoor},
   language = {eng},
   issn = {0048-9697},
   journal = {Science of the Total Environment},
   title = {Early-life exposure to household chemicals and wheezing in children},
   url = {https://www.sciencedirect.com/science/article/pii/S0048969719302438?via%3Dihub},
   volume = {663},
   year = {2019}
}

TY  - JOUR
ID  - 1548477
AU  - Mikeš, Ondřej - Vrbová, Markéta - Klánová, Jana - Čupr, Pavel - Švancara, Jan - Pikhart, Hynek
PY  - 2019
TI  - Early-life exposure to household chemicals and wheezing in children
JF  - Science of the Total Environment
VL  - 663
IS  - May
SP  - 418-425
EP  - 418-425
PB  - Elsevier Science
SN  - 00489697
KW  - Wheezing
KW  - Household chemicals
KW  - Asthma
KW  - ELSPAC
KW  - Cohort
KW  - Children
KW  - Indoor
UR  - https://www.sciencedirect.com/science/article/pii/S0048969719302438?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0048969719302438?via%3Dihub
N2  - The prevalence of the asthmatic symptoms among children increases globally over the time. Reduced exposure to pathogens in early childhood and increased exposure to anthropogenic irritants result in increased risk of wheezing in children, and all of this may be related to the usage of household chemicals. Objective of this analysis thus was to study the potential effects of overall exposure to home chemicals in the early life on the phenotypes of wheezing from birth until five years of age. 3411 mother-infant pairs from the Czech part of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC-CZ) participated in the study. The exposure was estimated by the composite household chemical score from 18 chemical-based products. Social, medical and environmental factors were taken into account as covariates in multivariable multinomial logistic regression using phenotypes of wheezing as a study outcome. We were able to determine the association between several wheezing childhood phenotypes and the frequent usage of household chemicals in the fully adjusted model. Statistically significant odds ratios (OR) for increasing exposures per 1 SD of exposure score were obtained for the intermediate onset transient (OR 1.27, 95% CI 1.10-1.47), intermediated onset persistent (OR 1.23, 95% CI 1.03-1.46), and early onset persistent phenotypes (OR 1.36, 95% CI 1.04-1.77) in comparison to never wheezing children. Moreover, the persistent phenotypes were significantly associated with school age asthma. Our study negative role of the increased household chemicals usage on the respiratory outcomes in children up to five years of age. Overall evaluation of the household chemical exposure may be useful tool for any large epidemiological studies.
ER  -

MIKEŠ, Ondřej, Markéta VRBOVÁ, Jana KLÁNOVÁ, Pavel ČUPR, Jan ŠVANCARA a Hynek PIKHART. Early-life exposure to household chemicals and wheezing in children. \textit{Science of the Total Environment}. Amsterdam: Elsevier Science, 2019, roč.~663, May, s.~418-425. ISSN~0048-9697. Dostupné z: https://dx.doi.org/10.1016/j.scitotenv.2019.01.254.

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