Environmental ototoxicants, a potential new class of chemical
stressors

J 2019

Environmental ototoxicants, a potential new class of chemical stressors

FABELOVA, Lucia, Christopher A. LOFFREDO, Jana KLÁNOVÁ, Klára HILSCHEROVÁ, Milena HORVAT et. al.

Základní údaje

Originální název

Environmental ototoxicants, a potential new class of chemical stressors

Autoři

FABELOVA, Lucia (703 Slovensko), Christopher A. LOFFREDO (840 Spojené státy), Jana KLÁNOVÁ (203 Česká republika, garant, domácí), Klára HILSCHEROVÁ (203 Česká republika, domácí), Milena HORVAT (705 Slovinsko), Juraj TIHANYI (703 Slovensko), Denisa RICHTEROVA (703 Slovensko), L'ubica MURÍNOVÁ (703 Slovensko), Sona WIMMEROVA (703 Slovensko), Renata SISTO (380 Itálie), Arturo MOLETI (380 Itálie) a Tomáš TRNOVEC (703 Slovensko)

Vydání

Environmental Research, SAN DIEGO, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019, 0013-9351

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30304 Public and environmental health

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.715

Kód RIV

RIV/00216224:14310/19:00110313

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.envres.2019.01.042

UT WoS

000460081300042

Klíčová slova anglicky

Ototoxicants; Environmental exposures; Hearing loss; Chemical mixtures; Adverse outcome pathway

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 3. 2020 16:46, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Hearing loss is an injury that can develop over time, and people may not even be aware of it until it becomes a severe disability. Ototoxicants are substances that may damage the inner ear by either affecting the structures in the ear itself or by affecting the nervous system. We have examined the possibility that ototoxicants may present a health hazard in association with environmental exposures, adding to existing knowledge of their proven hazards under medical therapeutic conditions or occupational activities. In addition to the already described human environmental ototoxicants, mainly organochlorines such as polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethylene (DDE), hexachlorocyclohexane (HCH) and hexachlorobenzene (HCB), we have examined the ubiquitous chemical stressors phthalates, bisphenol A/S/F/, PFCs, flame retardants (FRs) and cadmium for potential ototoxic properties, both as single substances or as chemical mixtures. Our literature review confirmed that these chemicals may disturb thyroid hormones homeostasis, activate aryl hydrocarbon receptor (AhR), and induce oxidative stress, which in turn may initiate a chain of events resulting in impairment of cochlea and hearing loss. With regard to auditory plasticity, diagnostics of a mixture of effects of ototoxicants, potential interactions of chemical and physical agents with effects on hearing, parallel deterioration of hearing due to chemical exposures and ageing, metabolic diseases or obesity, even using specific methods as brainstem auditory evoked potentials (BAEP) or otoacoustic emissions (OAEs) registration, may be difficult, and establishment of concentration-response relationships problematic. This paper suggests the establishment of a class of environmental oxotoxicants next to the established classes of occupational and drug ototoxicants. This will help to properly manage risks associated with human exposure to chemical stressors with ototoxic properties and adequate regulatory measures.

Návaznosti

733032, interní kód MU

Název: European Human Biomonitoring Initiative (Akronym: HBM4EU)

Investor: Evropská unie, European Human Biomonitoring Initiative, Health, demographic change and wellbeing (Societal Challenges)

Citovat

FABELOVA, Lucia, Christopher A. LOFFREDO, Jana KLÁNOVÁ, Klára HILSCHEROVÁ, Milena HORVAT, Juraj TIHANYI, Denisa RICHTEROVA, L'ubica MURÍNOVÁ, Sona WIMMEROVA, Renata SISTO, Arturo MOLETI a Tomáš TRNOVEC. Environmental ototoxicants, a potential new class of chemical stressors. Environmental Research. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019, roč. 171, April, s. 378-394. ISSN 0013-9351. Dostupné z: https://dx.doi.org/10.1016/j.envres.2019.01.042.

@article{1548478,
   author = {Fabelova, Lucia and Loffredo, Christopher A. and Klánová, Jana and Hilscherová, Klára and Horvat, Milena and Tihanyi, Juraj and Richterova, Denisa and Murínová, L'ubica and Wimmerova, Sona and Sisto, Renata and Moleti, Arturo and Trnovec, Tomáš},
   article_location = {SAN DIEGO},
   article_number = {April},
   doi = {http://dx.doi.org/10.1016/j.envres.2019.01.042},
   keywords = {Ototoxicants; Environmental exposures; Hearing loss; Chemical mixtures; Adverse outcome pathway},
   language = {eng},
   issn = {0013-9351},
   journal = {Environmental Research},
   title = {Environmental ototoxicants, a potential new class of chemical stressors},
   url = {https://www.sciencedirect.com/science/article/pii/S0013935119300477?via%3Dihub},
   volume = {171},
   year = {2019}
}

TY  - JOUR
ID  - 1548478
AU  - Fabelova, Lucia - Loffredo, Christopher A. - Klánová, Jana - Hilscherová, Klára - Horvat, Milena - Tihanyi, Juraj - Richterova, Denisa - Murínová, L'ubica - Wimmerova, Sona - Sisto, Renata - Moleti, Arturo - Trnovec, Tomáš
PY  - 2019
TI  - Environmental ototoxicants, a potential new class of chemical stressors
JF  - Environmental Research
VL  - 171
IS  - April
SP  - 378-394
EP  - 378-394
PB  - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN  - 00139351
KW  - Ototoxicants
KW  - Environmental exposures
KW  - Hearing loss
KW  - Chemical mixtures
KW  - Adverse outcome pathway
UR  - https://www.sciencedirect.com/science/article/pii/S0013935119300477?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0013935119300477?via%3Dihub
N2  - Hearing loss is an injury that can develop over time, and people may not even be aware of it until it becomes a severe disability. Ototoxicants are substances that may damage the inner ear by either affecting the structures in the ear itself or by affecting the nervous system. We have examined the possibility that ototoxicants may present a health hazard in association with environmental exposures, adding to existing knowledge of their proven hazards under medical therapeutic conditions or occupational activities. In addition to the already described human environmental ototoxicants, mainly organochlorines such as polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethylene (DDE), hexachlorocyclohexane (HCH) and hexachlorobenzene (HCB), we have examined the ubiquitous chemical stressors phthalates, bisphenol A/S/F/, PFCs, flame retardants (FRs) and cadmium for potential ototoxic properties, both as single substances or as chemical mixtures. Our literature review confirmed that these chemicals may disturb thyroid hormones homeostasis, activate aryl hydrocarbon receptor (AhR), and induce oxidative stress, which in turn may initiate a chain of events resulting in impairment of cochlea and hearing loss. With regard to auditory plasticity, diagnostics of a mixture of effects of ototoxicants, potential interactions of chemical and physical agents with effects on hearing, parallel deterioration of hearing due to chemical exposures and ageing, metabolic diseases or obesity, even using specific methods as brainstem auditory evoked potentials (BAEP) or otoacoustic emissions (OAEs) registration, may be difficult, and establishment of concentration-response relationships problematic. This paper suggests the establishment of a class of environmental oxotoxicants next to the established classes of occupational and drug ototoxicants. This will help to properly manage risks associated with human exposure to chemical stressors with ototoxic properties and adequate regulatory measures.
ER  -

FABELOVA, Lucia, Christopher A. LOFFREDO, Jana KLÁNOVÁ, Klára HILSCHEROVÁ, Milena HORVAT, Juraj TIHANYI, Denisa RICHTEROVA, L'ubica MURÍNOVÁ, Sona WIMMEROVA, Renata SISTO, Arturo MOLETI a Tomáš TRNOVEC. Environmental ototoxicants, a potential new class of chemical stressors. \textit{Environmental Research}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019, roč.~171, April, s.~378-394. ISSN~0013-9351. Dostupné z: https://dx.doi.org/10.1016/j.envres.2019.01.042.

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