Fluorinated Bambusurils as Highly Effective and Selective
Transmembrane Cl-/HCO3- Antiporters

J 2019

Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters

VALKENIER, Hennie, Omer Adeeb Hussein AKRAWI, Pia Yasmine JURČEK, Kristína SLEZIAKOVÁ, Tomáš LÍZAL et. al.

Základní údaje

Originální název

Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters

Autoři

VALKENIER, Hennie (56 Belgie), Omer Adeeb Hussein AKRAWI (368 Irák, domácí), Pia Yasmine JURČEK (246 Finsko, domácí), Kristína SLEZIAKOVÁ (703 Slovensko, domácí), Tomáš LÍZAL (203 Česká republika, domácí), Kristin BARTIK (56 Belgie) a Vladimír ŠINDELÁŘ (203 Česká republika, garant, domácí)

Vydání

CHEM, CAMBRIDGE, CELL PRESS, 2019, 2451-9294

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10400 1.4 Chemical sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Full Text

Impakt faktor

Impact factor: 19.735

Kód RIV

RIV/00216224:14310/19:00107547

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.chempr.2018.11.008

UT WoS

000458660100016

Klíčová slova anglicky

ANION TRANSPORT; MEDIATED TRANSPORT; CHLORIDE TRANSPORT; HIGH-AFFINITY; BICARBONATE; MEMBRANE; BINDING; POWERFUL; NITRATE; MACROCYCLE

Štítky

CF PROT, CF SAXS, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 2. 2023 21:30, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

The exchange of chloride and bicarbonate across lipid bilayers is an important biological process. Synthetic molecules can act as mobile carriers for these anions, although most show little selectivity. Here we report on three bambus[6] uril macrocycles functionalized with fluorinated benzyl groups, which are able to exchange Cl- and HCO3- efficiently. Remarkably, rates for Cl-/NO3- exchange are two orders of magnitude lower. The higher rates of a Cl-/HCO3- transport can be explained by the ability of the bambusurils to complex Cl- and HCO3- simultaneously, facilitating their exchange at the bilayer interface. Furthermore, the exceptionally high affinity and selectivity of these systems for NO3- appear to contribute to the poor Cl-/NO3- exchange. This work not only demonstrates the importance of anion binding characteristics on anion transport but also the potential relevance of bambusurils for anion transport applications considering the high rate observed for Cl-/HCO3- exchange.

Návaznosti

EF16_013/0001761, projekt VaV

Název: RECETOX RI

GA18-21801S, projekt VaV

Název: Chirální bambusurily

Investor: Grantová agentura ČR, Chirální bambusurily

LM2015043, projekt VaV

Název: Česká infrastruktura pro integrativní strukturní biologii (Akronym: CIISB)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Czech Infrastructure for Integrative Structural Biology

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

VALKENIER, Hennie, Omer Adeeb Hussein AKRAWI, Pia Yasmine JURČEK, Kristína SLEZIAKOVÁ, Tomáš LÍZAL, Kristin BARTIK a Vladimír ŠINDELÁŘ. Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters. CHEM. CAMBRIDGE: CELL PRESS, 2019, roč. 5, č. 2, s. 429-444. ISSN 2451-9294. Dostupné z: https://dx.doi.org/10.1016/j.chempr.2018.11.008.

@article{1548759,
   author = {Valkenier, Hennie and Akrawi, Omer Adeeb Hussein and Jurček, Pia Yasmine and Sleziaková, Kristína and Lízal, Tomáš and Bartik, Kristin and Šindelář, Vladimír},
   article_location = {CAMBRIDGE},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.chempr.2018.11.008},
   keywords = {ANION TRANSPORT; MEDIATED TRANSPORT; CHLORIDE TRANSPORT; HIGH-AFFINITY; BICARBONATE; MEMBRANE; BINDING; POWERFUL; NITRATE; MACROCYCLE},
   language = {eng},
   issn = {2451-9294},
   journal = {CHEM},
   title = {Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters},
   url = {https://www.sciencedirect.com/science/article/abs/pii/S2451929418305254?via%3Dihub},
   volume = {5},
   year = {2019}
}

TY  - JOUR
ID  - 1548759
AU  - Valkenier, Hennie - Akrawi, Omer Adeeb Hussein - Jurček, Pia Yasmine - Sleziaková, Kristína - Lízal, Tomáš - Bartik, Kristin - Šindelář, Vladimír
PY  - 2019
TI  - Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters
JF  - CHEM
VL  - 5
IS  - 2
SP  - 429-444
EP  - 429-444
PB  - CELL PRESS
SN  - 24519294
KW  - ANION TRANSPORT
KW  - MEDIATED TRANSPORT
KW  - CHLORIDE TRANSPORT
KW  - HIGH-AFFINITY
KW  - BICARBONATE
KW  - MEMBRANE
KW  - BINDING
KW  - POWERFUL
KW  - NITRATE
KW  - MACROCYCLE
UR  - https://www.sciencedirect.com/science/article/abs/pii/S2451929418305254?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/abs/pii/S2451929418305254?via%3Dihub
N2  - The exchange of chloride and bicarbonate across lipid bilayers is an important biological process. Synthetic molecules can act as mobile carriers for these anions, although most show little selectivity. Here we report on three bambus[6] uril macrocycles functionalized with fluorinated benzyl groups, which are able to exchange Cl- and HCO3- efficiently. Remarkably, rates for Cl-/NO3- exchange are two orders of magnitude lower. The higher rates of a Cl-/HCO3- transport can be explained by the ability of the bambusurils to complex Cl- and HCO3- simultaneously, facilitating their exchange at the bilayer interface. Furthermore, the exceptionally high affinity and selectivity of these systems for NO3- appear to contribute to the poor Cl-/NO3- exchange. This work not only demonstrates the importance of anion binding characteristics on anion transport but also the potential relevance of bambusurils for anion transport applications considering the high rate observed for Cl-/HCO3- exchange.
ER  -

VALKENIER, Hennie, Omer Adeeb Hussein AKRAWI, Pia Yasmine JURČEK, Kristína SLEZIAKOVÁ, Tomáš LÍZAL, Kristin BARTIK a Vladimír ŠINDELÁŘ. Fluorinated Bambusurils as Highly Effective and Selective Transmembrane Cl-/HCO3- Antiporters. \textit{CHEM}. CAMBRIDGE: CELL PRESS, 2019, roč.~5, č.~2, s.~429-444. ISSN~2451-9294. Dostupné z: https://dx.doi.org/10.1016/j.chempr.2018.11.008.

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