Widespread occurrence of retinoids in water bodies associated
with cyanobacterial blooms dominated by diverse species

J 2019

Widespread occurrence of retinoids in water bodies associated with cyanobacterial blooms dominated by diverse species

SEHNAL, Luděk, Tereza PROCHÁZKOVÁ, Marie SMUTNÁ, Jiří KOHOUTEK, Olga LEPSOVA-SKACELOVA et. al.

Základní údaje

Originální název

Widespread occurrence of retinoids in water bodies associated with cyanobacterial blooms dominated by diverse species

Autoři

SEHNAL, Luděk (203 Česká republika, domácí), Tereza PROCHÁZKOVÁ (203 Česká republika, domácí), Marie SMUTNÁ (203 Česká republika, domácí), Jiří KOHOUTEK (203 Česká republika, domácí), Olga LEPSOVA-SKACELOVA (203 Česká republika) a Klára HILSCHEROVÁ (203 Česká republika, garant, domácí)

Vydání

Water Research, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2019, 0043-1354

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10503 Water resources

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Full Text

Impakt faktor

Impact factor: 9.130

Kód RIV

RIV/00216224:14310/19:00107569

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.watres.2019.03.009

UT WoS

000466618400013

Klíčová slova anglicky

Cyanobacteria; Retinoids; Water bloom; Retinoid-like activity

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 3. 2020 10:51, Mgr. Marie Šípková, DiS.

Anotace

V originále

Cyanobacterial blooms represent a worldwide problem in freshwater as well as marine ecosystems as producers of various toxic compounds. This study provides environmentally important information about the common presence of mixtures of retinoids in various water bodies associated with the occurrence of cyanobacterial blooms dominated by many different species. The study documents, for the first time, that retinoids are produced by environmental cyanobacterial blooms dominated by species belonging to different genera such as Microcystis, Dolichospermum, Planktothrix, Woronichinia, Pseudanabaena and others. Samples of biomass of cyanobacterial blooms and their surrounding water were collected from seventeen independent freshwater bodies across the Czech Republic during summer 2015. Retinoid-like activity was detected by an in vitro reporter gene bioassay in water samples from 8 out of 17 localities with a maximal activity of 263 ng all-trans retinoic acid equivalent (REQ)/L. In comparison, in vitro assessment of biomass extracts documented retinoid-like activity at 11 out of 17 localities with a maximal retinoid-like activity of 867 ng REQ/g dry mass (dm). Individual retinoids were detected by chemical analyses in all water samples and in 16 out of 17 biomass samples with 4keto-retinal and all trans 5,6epoxy retinoic acid being detected in aquatic ecosystems for the first time. Further, all-trans 4keto retinoic acid and retinal were the most commonly detected compounds in both types of samples. With respect to retinoid-like activity, a large proportion was explained in some samples by contributions of individual detected retinoids calculated from their concentrations and relative potencies. However, results also indicate that other unknown compounds with a retinoic acid receptor-mediated mode of action were present. The revealed widespread production of retinoids by cyanobacterial blooms dominated by diverse species across various aquatic ecosystems and their common presence in both biomass and surrounding water raises concern namely because some retinoids belong to the most potent teratogens. These compounds need to be taken into consideration in the assessment of risks associated with massive cyanobacterial blooms.

Návaznosti

EF16_013/0001761, projekt VaV

Název: RECETOX RI

GA18-15199S, projekt VaV

Název: Bioaktivní látky ze sinic ovlivňující signálování jaderných receptorů a vývoj obratlovců

Investor: Grantová agentura ČR, Bioaktivní látky ze sinic ovlivňující signálování jaderných receptorů a vývoj obratlovců

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

SEHNAL, Luděk, Tereza PROCHÁZKOVÁ, Marie SMUTNÁ, Jiří KOHOUTEK, Olga LEPSOVA-SKACELOVA a Klára HILSCHEROVÁ. Widespread occurrence of retinoids in water bodies associated with cyanobacterial blooms dominated by diverse species. Water Research. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2019, roč. 156, June, s. 136-147. ISSN 0043-1354. Dostupné z: https://dx.doi.org/10.1016/j.watres.2019.03.009.

@article{1549381,
   author = {Sehnal, Luděk and Procházková, Tereza and Smutná, Marie and Kohoutek, Jiří and LepsovaandSkacelova, Olga and Hilscherová, Klára},
   article_location = {OXFORD},
   article_number = {June},
   doi = {http://dx.doi.org/10.1016/j.watres.2019.03.009},
   keywords = {Cyanobacteria; Retinoids; Water bloom; Retinoid-like activity},
   language = {eng},
   issn = {0043-1354},
   journal = {Water Research},
   title = {Widespread occurrence of retinoids in water bodies associated with cyanobacterial blooms dominated by diverse species},
   url = {https://www.sciencedirect.com/science/article/pii/S0043135419302210?via%3Dihub},
   volume = {156},
   year = {2019}
}

TY  - JOUR
ID  - 1549381
AU  - Sehnal, Luděk - Procházková, Tereza - Smutná, Marie - Kohoutek, Jiří - Lepsova-Skacelova, Olga - Hilscherová, Klára
PY  - 2019
TI  - Widespread occurrence of retinoids in water bodies associated with cyanobacterial blooms dominated by diverse species
JF  - Water Research
VL  - 156
IS  - June
SP  - 136-147
EP  - 136-147
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 00431354
KW  - Cyanobacteria
KW  - Retinoids
KW  - Water bloom
KW  - Retinoid-like activity
UR  - https://www.sciencedirect.com/science/article/pii/S0043135419302210?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0043135419302210?via%3Dihub
N2  - Cyanobacterial blooms represent a worldwide problem in freshwater as well as marine ecosystems as producers of various toxic compounds. This study provides environmentally important information about the common presence of mixtures of retinoids in various water bodies associated with the occurrence of cyanobacterial blooms dominated by many different species. The study documents, for the first time, that retinoids are produced by environmental cyanobacterial blooms dominated by species belonging to different genera such as Microcystis, Dolichospermum, Planktothrix, Woronichinia, Pseudanabaena and others. Samples of biomass of cyanobacterial blooms and their surrounding water were collected from seventeen independent freshwater bodies across the Czech Republic during summer 2015. Retinoid-like activity was detected by an in vitro reporter gene bioassay in water samples from 8 out of 17 localities with a maximal activity of 263 ng all-trans retinoic acid equivalent (REQ)/L. In comparison, in vitro assessment of biomass extracts documented retinoid-like activity at 11 out of 17 localities with a maximal retinoid-like activity of 867 ng REQ/g dry mass (dm). Individual retinoids were detected by chemical analyses in all water samples and in 16 out of 17 biomass samples with 4keto-retinal and all trans 5,6epoxy retinoic acid being detected in aquatic ecosystems for the first time. Further, all-trans 4keto retinoic acid and retinal were the most commonly detected compounds in both types of samples. With respect to retinoid-like activity, a large proportion was explained in some samples by contributions of individual detected retinoids calculated from their concentrations and relative potencies. However, results also indicate that other unknown compounds with a retinoic acid receptor-mediated mode of action were present. The revealed widespread production of retinoids by cyanobacterial blooms dominated by diverse species across various aquatic ecosystems and their common presence in both biomass and surrounding water raises concern namely because some retinoids belong to the most potent teratogens. These compounds need to be taken into consideration in the assessment of risks associated with massive cyanobacterial blooms.
ER  -

SEHNAL, Luděk, Tereza PROCHÁZKOVÁ, Marie SMUTNÁ, Jiří KOHOUTEK, Olga LEPSOVA-SKACELOVA a Klára HILSCHEROVÁ. Widespread occurrence of retinoids in water bodies associated with cyanobacterial blooms dominated by diverse species. \textit{Water Research}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2019, roč.~156, June, s.~136-147. ISSN~0043-1354. Dostupné z: https://dx.doi.org/10.1016/j.watres.2019.03.009.

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