SCHUTZ, Katharina, Diana ALECSANDRU, Bodo GRIMBACHER, Jamanda HADDOCK, Annemarie BRUINING, Gertjan DRIESSEN, Esther DE VRIES, Peter M. VAN HAGEN, Ieneke HARTMANN, Francesco FRAIOLI, Cinzia MILITO, Milica MITREVSKI, Isabella QUINTI, Goffredo SERRA, Peter KELLEHER, Michael LOEBINGER, Jiří LITZMAN, Věra POSTRÁNECKÁ, Vojtěch THON, Judith BABAR, Alison M. CONDLIFFE, Andrew EXLEY, Dinakantha KUMARARATNE, Nick SCREATON, Alison JONES, Maria P. BONDIONI, Vassilios LOUGARIS, Alessandro PLEBANI, Annarosa SORESINA, Cesare SIRIGNANO, Giuseppe SPADARO, Nermeen GALAL, Luis I. GONZALEZ-GRANADO, Sabine DETTMER, Robert STIRLING, Helen CHAPEL, Mary LUCAS, Smita PATEL, Claire-Michele FARBER, Isabelle MEYTS, Arpan K. BANERJEE, Scott HACKETT, John R. HURST, Klaus WARNATZ, Benjamin GATHMANN and Ulrich BAUMANN. Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group. Online. Journal of Clinical Immunology. New York: Springer, 2019, vol. 39, No 1, p. 45-54. ISSN 0271-9142. Available from: https://dx.doi.org/10.1007/s10875-018-0577-9. [citováno 2024-04-24]
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Basic information
Original name Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group
Authors SCHUTZ, Katharina (276 Germany), Diana ALECSANDRU (826 United Kingdom of Great Britain and Northern Ireland), Bodo GRIMBACHER (276 Germany), Jamanda HADDOCK (826 United Kingdom of Great Britain and Northern Ireland), Annemarie BRUINING (528 Netherlands), Gertjan DRIESSEN (528 Netherlands), Esther DE VRIES (528 Netherlands), Peter M. VAN HAGEN, Ieneke HARTMANN (528 Netherlands), Francesco FRAIOLI (380 Italy), Cinzia MILITO (380 Italy), Milica MITREVSKI (380 Italy), Isabella QUINTI (380 Italy), Goffredo SERRA (380 Italy), Peter KELLEHER (826 United Kingdom of Great Britain and Northern Ireland), Michael LOEBINGER (826 United Kingdom of Great Britain and Northern Ireland), Jiří LITZMAN (203 Czech Republic, belonging to the institution), Věra POSTRÁNECKÁ (203 Czech Republic), Vojtěch THON (203 Czech Republic, guarantor, belonging to the institution), Judith BABAR (826 United Kingdom of Great Britain and Northern Ireland), Alison M. CONDLIFFE (826 United Kingdom of Great Britain and Northern Ireland), Andrew EXLEY (826 United Kingdom of Great Britain and Northern Ireland), Dinakantha KUMARARATNE (826 United Kingdom of Great Britain and Northern Ireland), Nick SCREATON (826 United Kingdom of Great Britain and Northern Ireland), Alison JONES (826 United Kingdom of Great Britain and Northern Ireland), Maria P. BONDIONI (380 Italy), Vassilios LOUGARIS (380 Italy), Alessandro PLEBANI (380 Italy), Annarosa SORESINA (380 Italy), Cesare SIRIGNANO (380 Italy), Giuseppe SPADARO (380 Italy), Nermeen GALAL (818 Egypt), Luis I. GONZALEZ-GRANADO (724 Spain), Sabine DETTMER (276 Germany), Robert STIRLING (36 Australia), Helen CHAPEL (826 United Kingdom of Great Britain and Northern Ireland), Mary LUCAS (826 United Kingdom of Great Britain and Northern Ireland), Smita PATEL (826 United Kingdom of Great Britain and Northern Ireland), Claire-Michele FARBER (56 Belgium), Isabelle MEYTS (56 Belgium), Arpan K. BANERJEE (826 United Kingdom of Great Britain and Northern Ireland), Scott HACKETT (826 United Kingdom of Great Britain and Northern Ireland), John R. HURST (826 United Kingdom of Great Britain and Northern Ireland), Klaus WARNATZ (276 Germany), Benjamin GATHMANN (276 Germany) and Ulrich BAUMANN (276 Germany)
Edition Journal of Clinical Immunology, New York, Springer, 2019, 0271-9142.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30102 Immunology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 6.780
RIV identification code RIV/00216224:14110/19:00110433
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1007/s10875-018-0577-9
UT WoS 000458867500011
Keywords in English Chest CT; CVID; primary antibody deficiency; bronchiectasis; bronchial pathology
Tags 14110114, podil, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 21/1/2020 07:03.
Abstract
Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. We aimed to establish an international platform for the evaluation of bronchial pathology as assessed by chest CT and to describe the range of bronchial pathologies in patients with antibody deficiency. Ffteen immunodeficiency centres from 9 countries evaluated chest CT scans of patients with ADS using a predefined list of potential findings including an extent score for bronchiectasis. Data of 282 patients with ADS were collected. Patients with common variable immunodeficiency disorders (CVID) comprised the largest subgroup (232 patients, 82.3%). Eighty percent of CVID patients had radiological evidence of bronchial pathology including bronchiectasis in 61%, bronchial wall thickening in 44% and mucus plugging in 29%. Bronchiectasis was detected in 44% of CVID patients aged less than 20years. Cough was a better predictor for bronchiectasis than spirometry values. Delay of diagnosis as well as duration of disease correlated positively with presence of bronchiectasis. The use of consensus diagnostic criteria and a pre-defined list of bronchial pathologies allows for comparison of chest CT data in multicentre studies. Our data suggest a high prevalence of bronchial pathology in CVID due to late diagnosis or duration of disease.
Links
EF15_003/0000469, research and development projectName: Cetocoen Plus
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