Detection of a deletion at 22q11 locus involving
ZNF280A/ZNF280B/PRAME/GGTLC2 in B-cell malignancies: simply a
consequence of an immunoglobulin lambda light chain
rearrangement

J 2019

Detection of a deletion at 22q11 locus involving ZNF280A/ZNF280B/PRAME/GGTLC2 in B-cell malignancies: simply a consequence of an immunoglobulin lambda light chain rearrangement

MRÁZ, Marek a Šárka POSPÍŠILOVÁ

Základní údaje

Originální název

Detection of a deletion at 22q11 locus involving ZNF280A/ZNF280B/PRAME/GGTLC2 in B-cell malignancies: simply a consequence of an immunoglobulin lambda light chain rearrangement

Autoři

MRÁZ, Marek (203 Česká republika, garant, domácí) a Šárka POSPÍŠILOVÁ (203 Česká republika, domácí)

Vydání

British journal of haematology, England, Wiley-Blackwell, 2019, 0007-1048

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30205 Hematology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.518

Kód RIV

RIV/00216224:14740/19:00108506

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1111/bjh.15922

UT WoS

000478608100010

Klíčová slova anglicky

array CGH; chronic lymphocytic leukaemia; loss of 22q11; lambda light chain; deletion

Štítky

14110212, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 2. 2020 15:29, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

In this journal, Mestichelli et al (2018) recently reported that a submicroscopic 22q11 deletion is a potentially significant genomic aberration in chronic lymphocytic leukaemia (CLL), and that this alteration is missed by current routine techniques. This was based on the analysis of 23 CLL cases by oligonucleotide-based array comparative genomic hybridisation (aCGH; CytoChipCancer 4x180K, Illumina). The authors found 4 CLL cases with a deletion located at 22q11 that ranged in size from 0.68 Mb–0.49 Mb. The authors claimed that the minimally deleted region included the ZNF280A, ZNF280B, GGTLC2 and PRAME genes. The deletion in the 22q11 region was originally described by Gunn et al (2009) using aCGH and detected in 28 out of 187 analysed CLL cases.

Návaznosti

NV18-03-00054, projekt VaV

Název: ÚLOHA MICRORNA A JEJICH CÍLOVÝCH MOLEKUL V TRANSFORMACI FOLIKULÁRNÍHO LYMFOMU A AGRESIVITĚ CHRONICKÉ LYMFOCYTÁRNÍ LEUKÉMIE

Investor: Ministerstvo zdravotnictví ČR, ÚLOHA MICRORNA A JEJICH CÍLOVÝCH MOLEKUL V TRANSFORMACI FOLIKULÁRNÍHO LYMFOMU A AGRESIVITĚ CHRONICKÉ LYMFOCYTÁRNÍ LEUKÉMIE

Citovat

MRÁZ, Marek a Šárka POSPÍŠILOVÁ. Detection of a deletion at 22q11 locus involving ZNF280A/ZNF280B/PRAME/GGTLC2 in B-cell malignancies: simply a consequence of an immunoglobulin lambda light chain rearrangement. British journal of haematology. England: Wiley-Blackwell, 2019, roč. 186, č. 4, s. "E91"-"E94", 4 s. ISSN 0007-1048. Dostupné z: https://dx.doi.org/10.1111/bjh.15922.

@article{1550685,
   author = {Mráz, Marek and Pospíšilová, Šárka},
   article_location = {England},
   article_number = {4},
   doi = {http://dx.doi.org/10.1111/bjh.15922},
   keywords = {array CGH; chronic lymphocytic leukaemia; loss of 22q11; lambda light chain; deletion},
   language = {eng},
   issn = {0007-1048},
   journal = {British journal of haematology},
   title = {Detection of a deletion at 22q11 locus involving ZNF280A/ZNF280B/PRAME/GGTLC2 in B-cell malignancies: simply a consequence of an immunoglobulin lambda light chain rearrangement},
   url = {https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.15922},
   volume = {186},
   year = {2019}
}

TY  - JOUR
ID  - 1550685
AU  - Mráz, Marek - Pospíšilová, Šárka
PY  - 2019
TI  - Detection of a deletion at 22q11 locus involving ZNF280A/ZNF280B/PRAME/GGTLC2 in B-cell malignancies: simply a consequence of an immunoglobulin lambda light chain rearrangement
JF  - British journal of haematology
VL  - 186
IS  - 4
SP  - "E91"-"E94"
EP  - "E91"-"E94"
PB  - Wiley-Blackwell
SN  - 00071048
KW  - array CGH
KW  - chronic lymphocytic leukaemia
KW  - loss of 22q11
KW  - lambda light chain
KW  - deletion
UR  - https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.15922
L2  - https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.15922
N2  - In this journal, Mestichelli et al (2018) recently reported that a submicroscopic 22q11 deletion is a potentially significant genomic aberration in chronic lymphocytic leukaemia (CLL), and that this alteration is missed by current routine techniques. This was based on the analysis of 23 CLL cases by oligonucleotide-based array comparative genomic hybridisation (aCGH; CytoChipCancer 4x180K, Illumina). The authors found 4 CLL cases with a deletion located at 22q11 that ranged in size from 0.68 Mb–0.49 Mb. The authors claimed that the minimally deleted region included the ZNF280A, ZNF280B, GGTLC2 and PRAME genes. The deletion in the 22q11 region was originally described by Gunn et al (2009) using aCGH and detected in 28 out of 187 analysed CLL cases.
ER  -

MRÁZ, Marek a Šárka POSPÍŠILOVÁ. Detection of a deletion at 22q11 locus involving ZNF280A/ZNF280B/PRAME/GGTLC2 in B-cell malignancies: simply a consequence of an immunoglobulin lambda light chain rearrangement. \textit{British journal of haematology}. England: Wiley-Blackwell, 2019, roč.~186, č.~4, s.~''E91''-''E94'', 4 s. ISSN~0007-1048. Dostupné z: https://dx.doi.org/10.1111/bjh.15922.

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